Overview By Mayo Clinic Staff Print Cutaneous B-cell lymphoma is a rare type of cancer that begins in the white blood cells. This cancer attacks the skin. Cutaneous B-cell lymphoma affects one type of germ-fighting white blood cells called B cells. These cells also are called B lymphocytes. The types of cutaneous B-cell lymphoma include: Primary cutaneous follicle center lymphoma. Primary cutaneous marginal zone B-cell lymphoma. Primary cutaneous diffuse large B-cell lymphoma, leg type. Intravascular diffuse large B-cell lymphoma. Cutaneous B-cell lymphoma symptoms include a lump or group of lumps on the skin. Sometimes this cancer causes hard patches of skin. Cutaneous B-cell lymphoma is a type of non-Hodgkin lymphoma. Another type of non-Hodgkin lymphoma that affects the skin is called cutaneous T-cell lymphoma. Cutaneous T-cell lymphoma is more common than cutaneous B-cell lymphoma. Request an appointment Diagnosis & treatment Jan. 17, 2025 Print Share on: FacebookTwitter Living with cutaneous B-cell lymphoma? Connect with others like you for support and answers to your questions in the Blood Cancers & Disorders support group on Mayo Clinic Connect, a patient community. Blood Cancers & Disorders Discussions Essential thrombocythemia (ET): When to start hydroxyurea (HU)? 94 Replies Thu, Oct 09, 2025 chevron-right A Summary of My Multiple Myeloma 59 Replies Thu, Oct 09, 2025 chevron-right DVT (deep vein thrombosis) prevention and treatment 47 Replies Wed, Oct 08, 2025 chevron-right See more discussions Show references Primary cutaneous lymphomas. National Comprehensive Cancer Network. https://www.nccn.org/guidelines/guidelines-detail?category=1&id=1491. Accessed Oct. 10, 2024. Bolognia JL, et al. B-cell lymphomas of the skin. In: Dermatology. 5th ed. Elsevier; 2025. https://www.clinicalkey.com. Accessed Oct. 15, 2024. Cerroni L, et al. Infection by Borrelia burgdorferi and cutaneous B-cell lymphoma. Journal of Cutaneous Pathology. 1997; doi:10.1111/j.1600-0560.1997.tb01318.x. Related Products & Services A Book: Mayo Clinic Family Health Book Newsletter: Mayo Clinic Health Letter — Digital Edition Show more products and services from Mayo Clinic Cutaneous B-cell lymphomaSymptoms&causesDiagnosis&treatmentDoctors&departments Advertisement Mayo Clinic does not endorse companies or products. Advertising revenue supports our not-for-profit mission. Advertising & Sponsorship Policy Opportunities Ad Choices Mayo Clinic Press Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. NEW: Mayo Clinic Guide to Better Sleep Listen to Health Matters Podcast Mayo Clinic on Incontinence The Essential Diabetes Book FREE Mayo Clinic Diet Assessment Mayo Clinic Health Letter - FREE book CON-20306945 Diseases & Conditions Cutaneous B-cell lymphoma