Clinical Studies

Below are current clinical trials.

264 studies in Cardiovascular Diseases (open studies only).

Filter this list of studies by location, status and more.

  1. A Study of In Vitro Mapping of Cardiac Tissue Obtained from Patients with Refractory Arrhythmias who Underwent Heart Transplant or Replacement with Mechanical Heart

    1. Rochester, Minn.

    The purpose of this study is to obtain electro-anatomic maps of human myocardium in sinus rhythm and ventricular arrhythmias to identify activation patterns, identify and perform tissue ablation at targeted sites of interest that could play an important trigger for development of arrhythmias, and to perform histologic analysis of the myocardial tissue to identify triggers and/or targets for therapies to terminate ventricular arrhythmias.

  2. A Study of Minimally Invasive Pericardiotomy as a New Treatment for Heart Failure

    1. Rochester, Minn.

    The purpose of this study is to demonstrate acute effectiveness and safety of minimally-invasive pericardiotomy in patients with Heart Failure (HFpEF).

  3. A Study to Evaluate a New Method of Quantifying Muscle O2 Uptake and Blood Flow Using Near-Infrared Spectroscopy

    1. Rochester, Minn.

    The purpose of this study is to develop a new method of quantifying skeletal muscle metabolism and blood flow using Near-Infrared Spectroscopy Technology.

  4. A Study of an Implantable System for Remodulin Post Approval

    1. Rochester, Minn.

    The purposes of this study is to estimate the freedom from catheter-related complications through 5 years post-implant and to estimate the freedom from ISR pump failures through 5 years post- implant.

  5. A Study to Analyze Oxygen Consumption and Cardiac Output Measurements in Postural Orthostatic Tachycardia Syndrome

    1. Rochester, Minn.

    The purpose of this study is to describe the cardiac output and a-v O2 difference responses during cardiopulmonary exercise testing.

  6. An Extension Study of Mavacamten in Adults with Hypertrophic Cardiomyopathy Who Have Completed the MAVERICK-HCM (MYK-461-006) or EXPLORER-HCM (MYK-461-005) Trials (MAVA-LTE)

    1. Scottsdale/Phoenix, Ariz.

    The purpose of this study is to assess the long-term safety and tolerability of mavacamten in participants with hypertrophic cardiomyopathy (HCM) previously enrolled in 1 of 2 placebo-controlled trials: MAVERICK-HCM(MYK-461-006) or EXPLORER-HCM (MYK-461-005).

  7. A Study of Cardiopulmonary Exercise Heart Sound S1

    1. Rochester, Minn.

    The purpose of this study is to evaluate the ability to determine the first heart sound (S1) and its relationship to aerobic capacity.

  8. A Study of Levosimendan in Pulmonary Hypertension (PH) with Heart Failure (HF) and Preserved Left Ventricular Ejection Fraction (pEF) Patients

    1. Rochester, Minn.

    The purpose of this study is to evaluate for safety and effectiveness weekly, open-label doses of levosimendan over extended use in patients with pulmonary hypertension with heart failure and preserved left ventricular ejection fraction (PH-HFpEF).

  9. A Study to Evaluate Optimal Target of Activated Clotting Time During Percutaneous Coronary Intervention and Outcomes

    1. Jacksonville, Fla.
    2. Rochester, Minn.

    The purpose of this study is to test the hypothesis that lower ACT target ranges, as compared to higher target ranges, are associated with reduced rates of bleeding. 


  10. A Study to Evaluate the Effectiveness and Safety of Etripamil for the Termination of Spontaneous Paroxysmal Supraventricular Tachycardia (PSVT)

    1. Jacksonville, Fla.
    2. Rochester, Minn.

    The primary objective of this study is to determine whether etripamil nasal spray (NS) 70 mg is superior to placebo at terminating episodes of Paroxysmal Supraventricular Tachycardia (PSVT) in an outpatient setting.

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