Cardiovascular Diseases and Cardiac Surgery

Below are current clinical trials.

83 studies in Cardiovascular Diseases and Cardiac Surgery
(open studies only).

Filter this list of studies by location, status and more.

1. Immersive Virtual Reality for Reducing Pain and Anxiety in Patients With Temporary Mechanical Circulatory Support Awaiting Heart Transplantation.

   Jacksonville, Fla.

   Patients awaiting heart transplantation on temporary mechanical support often experience pain and anxiety, and their pre-transplant hospital course is often prolonged. We intend to investigate whether an immersive Virtual Reality headset can improve patients pain and anxiety while awaiting cardiac transplantation using specific patient surveys to assess pain, anxiety, and resilience. 

2. Pulmonary Circulation And Alveolar-Capillary Reserve In Single Ventricle Hearts

   Rochester, Minn.

   The purpose of this study is to investigate alterations in pulmonary vascular physiology and respiratory gas exchange at rest and during exercise (mimicking daily activities) in patients with single ventricle heart disease (SVHD) using novel noninvasive methods developed in our laboratory.

3. TRITON-CM: A Study To Evaluate Nucresiran In Patients With Transthyretin Amyloidosis With Cardiomyopathy

   Rochester, Minn.

   The purpose of this study is to:
   
   * Evaluate the efficacy of nucresiran compared to placebo on reducing all-cause mortality and cardiovascular (CV) events
   * Evaluate the efficacy of nucresiran compared to placebo on additional assessments of CV events and/or death
   * Evaluate the efficacy of nucresiran compared to placebo on patient-reported health status and health-related quality of life

4. Transcatheter Mitral Valve Repair For Inotrope Dependent Cardiogenic Shock (MINOS)

   Rochester, Minn.

   The purpose of this study is to determine if transesophageal echocardiogram repair (TEER) in patients with society for cardiovascular angiography and interventions (SCAI) stage C or D cardiogenic with concomitant moderate or greater mitral regurgitation improve outcomes as compared to medical therapy.

    

5. His Bundle Pacing in Bradycardia and Heart Failure

   Rochester, Minn.

   Participants in this study will either have heart failure (HF) and are scheduled to undergo cardiac resynchronization therapy pacemaker (CRT-P) or cardiac resynchronization therapy defibrillator (CRT-D) implantation, or have atrioventricular (AV) block and are scheduled to undergo pacemaker implantation. In this study additional heart rhythm measurements will be collected during the implant procedure to better understand how His bundle and/or parahisian pacing (HISP) effects electrical conduction in the hearts of patients with HF or AV block. The hypothesis is that His bundle or parahisian pacing (HISP) may normalize atrioventricular (AV) conduction with a narrow combination of the Q wave, R wave and S wave (QRS complex) in functional bundle branch block or conduction delay in patients with heart failure (HF).

6. Hospital Diuretic Therapy and Associated Risk of Heart Failure in Treating Fluid Volume Overload

   Rochester, Minn.

   The objective of this proposal is to assess blood-plasma volume (TBV-PV) status quantitatively in patients with DHF admitted to hospital for volume management, and to determine how effective standard diuretic therapy is in achieving euvolemia and the impact of their quantitated volume status at the time of hospital discharge on heart failure related morality and re-hospitalizations. Thus, to determine if quantitative blood volume analysis could potentially serve as an effective tool to guide more effective in-hospital diuretic therapy to achieve better outcomes in patients hospitalized with clinically identified volume overload.

7. A Study of Sexual Dysfunction in Patients with Hypertrophic Obstructive Cardiomyopathy Undergoing Septal Myectomy

   Rochester, Minn.

   The purpose of this study is to determine how many patients suffer from sexual function problems and ascertain if they are improved or modified by cardiac surgical intervention.

8. the Mayo Cardiac Sarcoid Registry

   Rochester, Minn., Jacksonville, Fla.

   Aims, purpose, or objectives:

   1. Develop a retrospective registry of patients with cardiac sarcoidosis
   2. Develop a prospective registry of patients with cardiac sarcoidosis
   3. Understand the natural history of cardiac sarcoidosis through evaluation of outcomes of patients in the registry
   4. Determine risk factors for sarcoid involvement of the heart
   5. Evaluate outcomes of patients both treated and untreated with cardiac sarcoidosis
   6. Understand the complications of untreated and treated cardiac sarcoidosis

    

9. A Study to Identify the Genetic Defect(s) in Individuals with Arrhythmogenic Bi-Leaflet Mitral Prolapse (aBiMVP)

   Rochester, Minn.

   The purpose of this study is to elucidate the genetic basis of aBiMVP in hopes of determining novel mechanisms that underlie aBiMVP pathogenesis.

10. A Study to Evaluate Aortic Dilatation in Patients with Conotruncal Abnormalities

    Rochester, Minn.

    The purpose of this study is to assess operative and postoperative outcomes after aortic valve surgery, evaluate for changes in ascending aorta diameter by comparing pre-operative CT imaging to measurements on follow-up imaging, and examine late outcomes and functional status during the follow-up period with specific focus on mortality, need for re-operation and incidence of aortic dissection.