Clinical Trials Below are current clinical trials.110 studies in Cardiovascular Diseases and Cardiac Surgery (open studies only). Filter this list of studies by location, status and more. A Study of Lung Ultrasound to Assess Extravascular Lung Water Rochester, Minn. The purpose of this study is to determine if lung ultrasound surface wave elastography (LUSWE) can accurately detect changes in lung elasticity (compliance) caused by the presence of extravascular lung water (pulmonary edema). Expanded Access Protocol of Patisiran for Patients With Hereditary ATTR Amyloidosis (hATTR) Rochester, Minn. The purpose of this study is to provide expanded access of patisiran to patients with hereditary transthyretin-mediated amyloidosis (hATTR). His Bundle Pacing in Bradycardia and Heart Failure Rochester, Minn. Participants in this study will either have heart failure (HF) and are scheduled to undergo cardiac resynchronization therapy pacemaker (CRT-P) or cardiac resynchronization therapy defibrillator (CRT-D) implantation, or have atrioventricular (AV) block and are scheduled to undergo dual chamber pacemaker implantation. In this study additional heart rhythm measurements will be collected during the implant procedure to better understand how His bundle and/or parahisian pacing (HISP) effects electrical conduction in the hearts of patients with HF or AV block. The hypothesis is that His bundle or parahisian pacing (HISP) may normalize atrioventricular (AV) conduction with a narrow combination of the Q wave, R wave and S wave (QRS complex) in functional bundle branch block or conduction delay in patients with heart failure (HF). A Study to Assess Non-invasive Arterial Air Plethysmography of Normal and Abnormal Arterial Hemodynamics Rochester, Minn. The purpose of this study is to determine the accuracy (sensitivity, specificity, negative predictive value, positive predictive value) of a non-invasive arterial air plethysmography prototype in people with normal and abnormal arterial hemodynamics. A Study of Sexual Dysfunction in Patients with Hypertrophic Obstructive Cardiomyopathy Undergoing Septal Myectomy Rochester, Minn. The purpose of this study is to determine how many patients suffer from sexual function problems and ascertain if they are improved or modified by cardiac surgical intervention. A Study to Compare the Effectiveness of Different High-intensity Interval Training Programs in Cardiac Rehabilitation Rochester, Minn. The main purpose of the study is to examine the effect of two different high intensity interval training (HIIT) prescription approaches on improving fitness, heart function, and the ability of the body's muscles to receive oxygen. The two approaches of the same total exercise durston will include: 1) HIIT with progressively increased interval durations (PRO-HIIT) versus 2) HIIT with constant shorter interval durations (CON-HIIT). The study hypothesis is that the progressively increased interval duration at high-intensity (PRO-HIIT) will result in a greater increases in fitness, heart function, and the ability of the body's muscles to receive oxygen in patients enrolled in cardiac rehabilitation. Hospital Diuretic Therapy and Associated Risk of Heart Failure in Treating Fluid Volume Overload Rochester, Minn. The objective of this proposal is to assess blood-plasma volume (TBV-PV) status quantitatively in patients with DHF admitted to hospital for volume management, and to determine how effective standard diuretic therapy is in achieving euvolemia and the impact of their quantitated volume status at the time of hospital discharge on heart failure related morality and re-hospitalizations. Thus, to determine if quantitative blood volume analysis could potentially serve as an effective tool to guide more effective in-hospital diuretic therapy to achieve better outcomes in patients hospitalized with clinically identified volume overload. Evaluation of the GORE® EXCLUDER® Thoracoabdominal Branch Endoprosthesis in the Treatment of Thoracoabdominal and Pararenal Aortic Aneurysms Rochester, Minn. The purpose of this study is assess the safety and effectiveness of the GORE® EXCLUDER® Thoracoabdominal Branch Endoprost (TAMBE) Device in the treatment of thoracoabdominal and pararenal aortic aneurysms. the Mayo Cardiac Sarcoid Registry Rochester, Minn., Jacksonville, Fla. Aims, purpose, or objectives: Develop a retrospective registry of patients with cardiac sarcoidosis Develop a prospective registry of patients with cardiac sarcoidosis Understand the natural history of cardiac sarcoidosis through evaluation of outcomes of patients in the registry Determine risk factors for sarcoid involvement of the heart Evaluate outcomes of patients both treated and untreated with cardiac sarcoidosis Understand the complications of untreated and treated cardiac sarcoidosis (FMD Impact Registry) Fibromuscular Dysplasia Findings and Outcomes Rochester, Minn. To describe the clinical, laboratory, pathologic, imaging findings, therapy and outcomes in all patients with Fibromuscular Dysplasia (FMD) and/or segmental arterial mediolysis evaluated at Mayo Clinic retrospectively (back to 01/01/1990) and prospectively (starting 04/13/2016). 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