Valley fever is a fungal infection caused by coccidioides (kok-sid-e-OY-deze) organisms. It can cause signs and symptoms such as a fever, cough and tiredness.

Two coccidioides fungi species cause valley fever. These fungi are commonly found in soil in specific regions. The fungi's spores can be stirred into the air by anything that disrupts the soil, such as farming, construction and wind.

People can then breathe the fungi into their lungs. The fungi can cause valley fever, also known as acute coccidioidomycosis (kok-sid-e-oy-doh-my-KOH-sis). Mild cases of valley fever usually resolve on their own. In more-severe cases, doctors treat the infection with antifungal medications.

March 21, 2023
  1. Valley fever (coccidioidomycosis). Centers for Disease Control and Prevention. https://www.cdc.gov/fungal/diseases/coccidioidomycosis/index.html. Accessed July 9, 2020.
  2. Ferri FF. Coccidioidomycosis. In: Ferri's Clinical Advisor 2020. Elsevier; 2020. https://www.clinicalkey.com. Accessed July 8, 2020.
  3. Blair JE, et al. Pulmonary primary coccidioidal infection. https://www.uptodate.com/contents/search. Accessed July 9, 2020.
  4. Coccidioidomycosis. In: Elsevier Point of Care. Elsevier; 2020. https://www.clinicalkey.com. Accessed July 8, 2020.
  5. AskMayoExpert. Coccidioidomycosis. Mayo Clinic; 2020.
  6. Jameson JL, et al., eds. Coccidioidomycosis. In: Harrison's Principles of Internal Medicine. 20th ed. The McGraw-Hill Companies; 2018. https://accessmedicine.mhmedical.com. Accessed July 9, 2020.
  7. Bennett JE, et al. Coccidioidomycosis (Coccidioidies species). In: Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 9th ed. Elsevier; 2020. https://www.clinicalkey.com. Accessed July 9, 2020.
  8. Valley fever (coccidioidomycosis) statistics. Centers for Disease Control and Prevention. https://www.cdc.gov/fungal/diseases/coccidioidomycosis/statistics.html. Accessed March 1, 2023.
  9. Huff D, et al. Coccidioidomycosis and COVID-19 infection. An analysis from a single medical center within the coccidioidal endemic area. Mycopathologia. 2022; doi:10.1007/s11046-022-00629-6.
  10. Jugler C, et al. Humanization and expression of IgG and IgM antibodies in plants as potential diagnostic reagents for valley fever. Frontiers in Plant Science. 2022; doi:10.3389/fpls.2022.925008.
  11. Coccidioidomycosis clinical trials at Mayo Clinic. Mayo Clinic; 2023. https://www.mayo.edu/research/clinical-trials/search-results?keyword=coccidioidomycosis&studySiteStatusesGrouped=Open/Status%20Unknown. Accessed Jan. 30, 2023.
  12. Vallabhaneni S, et al. The global burden of fungal diseases. Infectious Disease Clinics of North America. 2016; doi: 10.1016/j.idc.2015.10.004.
  13. O'Shaughnessy E, et al. FDA public workshop summary — Coccidioidomycosis (valley fever): Considerations for development of antifungal drugs. Clinical Infectious Diseases. 2022; doi:10.1093/cid/ciab904.
  14. Nguyen HT. Allscripts EPSi. Mayo Clinic. Feb. 28, 2023.
  15. Brewer AC, et al. Cutaneous effects associated with fluconazole in patients treated for coccidioidomycosis. International Journal of Dermatology. 2019; doi:10.1111/ijd.14238.


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