Tests and procedures used to diagnose sclerosing mesenteritis include:

  • Physical exam. During a physical exam, your doctor will look for clues that may help determine your diagnosis. For instance, sclerosing mesenteritis often forms a mass in your upper abdomen that can be felt during a physical exam.
  • Imaging tests. Imaging tests of your abdomen may reveal sclerosing mesenteritis. Imaging tests may include computerized tomography (CT) or magnetic resonance imaging (MRI).
  • Removing a sample of tissue for testing (biopsy). If you're experiencing sclerosing mesenteritis signs and symptoms, your doctor may recommend a biopsy to rule out other diseases and to make a definitive diagnosis. A biopsy sample may be collected by inserting a long needle through your skin or during surgery.

    Before starting treatment, doctors will do a biopsy to confirm the diagnosis and rule out other possibilities, including certain cancers such as lymphoma and carcinoid.


You may be diagnosed with sclerosing mesenteritis while you are receiving care for another condition. If you are not experiencing discomfort from sclerosing mesenteritis, you may not require treatment. Instead, your doctor may recommend periodic imaging tests to monitor your condition.

If you begin to experience signs and symptoms of sclerosing mesenteritis, you may choose to begin treatment.


Medications for sclerosing mesenteritis are intended to control inflammation. Medications may include:

  • Corticosteroids. Corticosteroids such as prednisone control inflammation. Corticosteroids can be used alone but are usually combined with other medications. They are not generally used more than three to four months because of side effects.
  • Hormone therapy. Hormone treatments such as tamoxifen may slow the growth of scar tissue. Tamoxifen (Soltamox) is typically combined with corticosteroids or other medications and may be used long term. Tamoxifen increases the risk of blood clots and is typically combined with a daily aspirin to reduce this risk. Progesterone (Prometrium) may be used as an alternative to tamoxifen, but it also has significant side effects.
  • Other drugs. Several other medications have been used to treat sclerosing mesenteritis, such as azathioprine (Imuran, Azasan), colchicine (Colcrys, Mitigare), cyclophosphamide and thalidomide (Thalomid).


If sclerosing mesenteritis advances to block the flow of food through your digestive system, you may need surgery to remove the blockage.

Sclerosing mesenteritis care at Mayo Clinic

Sept. 29, 2021
  1. Green MS, et al. Sclerosing mesenteritis: A comprehensive clinical review. Annals of Translational Medicine. 2018; doi:10.21037/atm.2018.07.01. Accessed Oct. 14, 2019.
  2. Danford CJ, et al. Sclerosing mesenteritis. The American Journal of Gastroenterology. 2019; doi:10.14309/ajg.0000000000000167. Accessed Oct. 14, 2019.
  3. Friedman LS. Sclerosing mesenteritis. https://www.uptodate.com/contents/search. Accessed Oct. 14, 2019.
  4. Brown AY. Allscripts EPSi. Mayo Clinic, Rochester, Minn. Aug. 22, 2019.


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