Sclerosing mesenteritis care at Mayo Clinic

Your Mayo Clinic care team

At Mayo Clinic, digestive disease specialists (gastroenterologists), radiologists, pathologists and surgeons work as a multidisciplinary team to care for people with sclerosing mesenteritis. Other professionals are included as needed.

Advanced diagnosis and treatment

Mayo Clinic doctors will work with you to review all of your treatment options and choose the treatment that best suits your needs and goals. The range of treatments offered to people with sclerosing mesenteritis includes medications and surgery.

Tests and procedures used to diagnose sclerosing mesenteritis include:

  • Physical exam. During a physical exam, your doctor will look for clues that may help determine your diagnosis. For instance, sclerosing mesenteritis often forms a mass in your upper abdomen that can be felt during a physical exam.
  • Imaging tests. Imaging tests of your abdomen may reveal sclerosing mesenteritis. Imaging tests may include computerized tomography (CT) or magnetic resonance imaging (MRI).
  • Removing a sample of tissue for testing (biopsy). If you're experiencing sclerosing mesenteritis signs and symptoms, your doctor may recommend a biopsy to rule out other diseases and to make a definitive diagnosis. A biopsy sample may be collected by inserting a long needle through your skin or during surgery.

    Before starting treatment, doctors will do a biopsy to confirm the diagnosis and rule out other possibilities, including certain cancers such as lymphoma and carcinoid.

Treatment may not be necessary

You may be diagnosed with sclerosing mesenteritis while you are receiving care for another condition. If you are not experiencing discomfort from sclerosing mesenteritis, you may not require treatment. Instead, your doctor may recommend periodic imaging tests to monitor your condition.

If you begin to experience signs and symptoms of sclerosing mesenteritis, you may choose to begin treatment.


Medications for sclerosing mesenteritis are intended to control inflammation. Medications may include:

  • Corticosteroids. Corticosteroids such as prednisone (Prednisone Intensol) control inflammation. Corticosteroids can be used alone but are usually combined with other medications. They are not generally used more than 3-4 months because of side effects.
  • Hormone therapy. Hormone treatments such as tamoxifen may slow the growth of scar tissue. Tamoxifen (Soltamox) is typically combined with corticosteroids or other medications and may be used long term. Tamoxifen increases the risk of blood clots and is typically combined with a daily aspirin to reduce this risk. Progesterone (Prometrium) may be used as an alternative to tamoxifen but it also has significant side effects.
  • Other drugs. Several other medications have been used to treat sclerosing mesenteritis, such as azathioprine (Imuran, Azasan), colchicine (Probenecid-Colchicine, Colcrys), cyclophosphamide and thalidomide (Thalomid).


If sclerosing mesenteritis advances to block the flow of food through your digestive system, you may need surgery to remove the blockage.

Expertise and rankings

  • Diagnostic expertise. Sclerosing mesenteritis is often mistaken for other digestive diseases. Mayo Clinic doctors are experienced in the techniques necessary for making the correct diagnosis.
  • Experience. Mayo Clinic doctors have experience diagnosing and treating this rare condition. Mayo Clinic doctors care for more than 200 people with sclerosing mesenteritis each year.

Mayo Clinic in Rochester, Minn., ranks No. 1 as the best gastroenterology and gastrointestinal (GI) surgery hospital in the U.S. News & World Report Best Hospitals rankings. Mayo Clinic in Phoenix/Scottsdale, Ariz., is ranked among the Best Hospitals and Mayo Clinic in Jacksonville, Fla., is ranked highly performing for gastroenterology and GI surgery by U.S. News & World Report.

Learn more about Mayo Clinic's gastroenterology and hepatology expertise and rankings.

Locations, travel and lodging

Mayo Clinic has major campuses in Phoenix and Scottsdale, Arizona; Jacksonville, Florida; and Rochester, Minnesota. The Mayo Clinic Health System has dozens of locations in several states.

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Costs and insurance

Mayo Clinic works with hundreds of insurance companies and is an in-network provider for millions of people.

In most cases, Mayo Clinic doesn't require a physician referral. Some insurers require referrals, or may have additional requirements for certain medical care. All appointments are prioritized on the basis of medical need.

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Please contact your insurance company to verify medical coverage and to obtain any needed authorization prior to your visit. Often, your insurer's customer service number is printed on the back of your insurance card.

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Dec. 20, 2018