Print OverviewRestless legs syndrome (RLS) is a condition that causes a very strong urge to move the legs. The need to move usually is caused by aching or an uncomfortable feeling in the legs. It typically happens in the evening or at night when sitting or lying down. Moving eases the feeling for a short time. Restless legs syndrome can begin at any age and tends to get worse with age. It can make it hard to sleep, which affects daily activities. RLS also is known as Willis-Ekbom disease. Simple self-care steps and lifestyle changes may help relieve symptoms. Medicines also help many people with RLS.Products & ServicesA Book: Mayo Clinic Family Health BookA Book: Mayo Clinic Guide to Better SleepA Book: Mayo Clinic Guide to Home RemediesNewsletter: Mayo Clinic Health Letter — Digital EditionShow more products from Mayo Clinic SymptomsWhen to see a doctorTalk with your healthcare professional if you have symptoms of restless legs syndrome. RLS can interfere with your sleep, cause daytime drowsiness and affect your quality of life. Request an appointment There is a problem with information submitted for this request. Review/update the information highlighted below and resubmit the form. From Mayo Clinic to your inbox Sign up for free and stay up to date on research advancements, health tips, current health topics, and expertise on managing health. Click here for an email preview. Email Address 1 ErrorEmail field is required ErrorInclude a valid email address Learn more about Mayo Clinic’s use of data. We use the data you provide to deliver you the content you requested. To provide you with the most relevant and helpful information, we may combine your email and website data with other information we have about you. If you are a Mayo Clinic patient, we will only use your protected health information as outlined in our Notice of Privacy Practices. You may opt out of email communications at any time by clicking on the unsubscribe link in the email. Subscribe! Thank you for subscribing! You'll soon start receiving the latest Mayo Clinic health information you requested in your inbox. Sorry something went wrong with your subscription Please, try again in a couple of minutes Retry CausesHereditySometimes RLS runs in families, especially if the condition starts before age 40. Researchers have found sites on the chromosomes where genes linked to RLS may be present. ComplicationsRestless legs syndrome (RLS) symptoms can range from mild to serious. Many people with the condition find it hard to fall asleep or stay asleep, which may affect their quality of life. This can cause depression in some people. Not being able to sleep also may lead to excessive daytime drowsiness. RLS can even interfere with napping. By Mayo Clinic Staff Restless legs syndrome care at Mayo Clinic Request an appointment Diagnosis & treatment June 30, 2026 PrintShow references Restless legs syndrome. National Institute of Neurological Disorders and Stroke. https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Fact-Sheets/Restless-Legs-Syndrome-Fact-Sheet. Accessed Sept. 14, 2025. Ondo WG. Clinical features and diagnosis of restless legs syndrome and periodic limb movement disorder in adults. https://www.uptodate.com/contents/search. Accessed Sept. 14, 2025. Silber MH. Management of restless legs syndrome and periodic limb movement disorder in adults. https://www.uptodate.com/contents/search. Accessed Sept. 14, 2025. Winkelman JW, et al. Treatment of restless legs syndrome and periodic limb movement disorder: An American Academy of Sleep Medicine systematic review, meta-analysis, and GRADE assessment. Journal of Clinical Sleep Medicine. 2025; doi:10.5664/jcsm.11392. Gossard TR, et al. Restless legs syndrome: Contemporary diagnosis and treatment. Neurotherapeutics. 2021; doi:10.1007/s13311-021-01019-4. Allen RP, et al. Restless legs syndrome/Willis-Ekbom disease diagnostic criteria: Updated International Restless Legs Syndrome Study Group (IRLSSG) consensus criteria — history, rationale, description, and significance. Sleep Medicine. 2014; doi:10.1016/j.sleep.2014.03.025. Xu Y, et al. Unraveling restless legs syndrome: A comprehensive review of current research and future directions. International Journal of General Medicine. 2025; doi:10.2147/IJGM.S544680. Ferri FF. Restless legs syndrome. In: Ferri's Clinical Advisor 2026. Elsevier; 2026. https://www.clinicalkey.com. Accessed Sept. 14, 2025. Ami TR. Allscripts EPSi. Mayo Clinic. Nov. 14, 2023. Song P, et al. The global and regional prevalence of restless legs syndrome among adults: A systematic review and modelling analysis. Journal of Global Health. 2024; doi:10.7189/jogh.14.04113. Winkelman JW, et al. Treatment of restless legs syndrome and periodic limb movement disorder: An American Academy of Sleep Medicine clinical practice guideline. Journal of Clinical Sleep Medicine. 2025; doi:10.5664/jcsm.11390. Sleep center directory. American Academy of Sleep Medicine. https://sleepeducation.org/sleep-center. Accessed Sept. 22, 2025. Kellerman RD, et al. Sleep disorders. In: Conn's Current Therapy 2025. Elsevier; 2025. https://www.clinicalkey.com. Accessed Sept. 14, 2025. Silber MH, et al. The management of restless legs syndrome: An updated algorithm. Mayo Clinic Proceedings. 2021; doi:10.1016/j.mayocp.2020.12.026. 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There is a problem with information submitted for this request. Review/update the information highlighted below and resubmit the form. From Mayo Clinic to your inbox Sign up for free and stay up to date on research advancements, health tips, current health topics, and expertise on managing health. Click here for an email preview. Email Address 1 ErrorEmail field is required ErrorInclude a valid email address Learn more about Mayo Clinic’s use of data. We use the data you provide to deliver you the content you requested. To provide you with the most relevant and helpful information, we may combine your email and website data with other information we have about you. If you are a Mayo Clinic patient, we will only use your protected health information as outlined in our Notice of Privacy Practices. You may opt out of email communications at any time by clicking on the unsubscribe link in the email. Subscribe! Thank you for subscribing! You'll soon start receiving the latest Mayo Clinic health information you requested in your inbox. Sorry something went wrong with your subscription Please, try again in a couple of minutes Retry