Your doctor will examine your skin, possibly touching it in places to determine the borders of the affected area.

In most cases, no tests are necessary.


No single treatment relieves postherpetic neuralgia for everyone. It often takes a combination of treatments to reduce the pain.

Lidocaine skin patches

These are small, bandage-like patches that contain the topical pain-relieving medication lidocaine. These patches can be cut to fit only the affected area. You apply the patches, available by prescription or over-the-counter at a slightly lower dosage, directly to painful skin to deliver temporary relief.

Capsaicin skin patch

A high concentration of an extract of chili peppers (capsaicin) is available as a skin patch (Qutenza) to relieve pain. Available only in your doctor's office, the patch is applied by trained personnel after using a numbing medication on the affected area.

The process takes at least two hours because you need to be monitored after the high-concentration patch is applied, but a single application decreases pain for some people for up to three months. If it works, the application can be repeated every three months.


Certain anti-seizure medications, including gabapentin (Gralise, Horizant, Neurontin) and pregabalin (Lyrica), can lessen the pain of postherpetic neuralgia. These medications stabilize abnormal electrical activity in your nervous system caused by injured nerves. Side effects include drowsiness, unclear thinking, unsteadiness and swelling in the feet.


Certain antidepressants — such as nortriptyline (Pamelor), amitriptyline, duloxetine (Cymbalta) and venlafaxine (Effexor XR) — affect key brain chemicals that play a role in both depression and how your body interprets pain. Doctors often prescribe antidepressants for postherpetic neuralgia in smaller doses than they do for depression alone.

Common side effects of these medications include drowsiness, dry mouth, lightheadedness and weight gain.

Opioid painkillers

Some people might need prescription-strength pain medications containing tramadol (Ultram, Conzip), oxycodone (Percocet, Roxicet) or morphine. Opioids can cause mild dizziness, drowsiness, confusion and constipation.

However, recent CDC guidelines urge doctors to consider treatments other than opioids for pain that isn't cancer-related, such as the pain of postherpetic neuralgia. This is based on increasing recognition of the risk of addiction and death in some people using opioids.

If prescribed, opioids need to be monitored closely, used at the lowest possible dose and considered only in situations where safer medications have failed.

Opioid medication can impair your ability to drive and should not be combined with alcohol or other drugs.

Steroid injections

Steroids are sometimes injected into the spine (intrathecal or epidural) for postherpetic neuralgia. However, evidence of effectiveness is inconsistent. A low risk of serious side effects, including meningitis, has been associated with their use.

Lifestyle and home remedies

The following over-the-counter medications may ease the pain of postherpetic neuralgia:

  • Capsaicin. Capsaicin cream, made from the seeds of hot chili peppers, might relieve pain from postherpetic neuralgia. Capsaicin (Capzasin-P, Zostrix, others) can cause a burning sensation and irritate your skin, but these side effects usually disappear over time.

    Because capsaicin cream can irritate your skin, avoid getting it on unaffected parts of your body. Follow instructions, including wearing gloves for application and washing your hands thoroughly after applying.

  • Topical analgesics and anesthetics. Aspirin crushed and mixed into an absorbing cream or nonprescription-strength lidocaine cream might reduce skin hypersensitivity.

Preparing for your appointment

You might start by seeing your family doctor. He or she may refer you to a nerve specialist (neurologist) or a doctor who specializes in treating chronic pain.

Here's information to help you get ready for your appointment.

What you can do

When you make the appointment, ask if there's anything you need to do in advance, such as fasting before a specific test. Make a list of:

  • Your symptoms, including any that seem unrelated to the reason for your appointment, and when they began
  • Key personal information, including major stresses, recent life changes and family medical history
  • All medications, vitamins or other supplements you take, including doses
  • Questions to ask your doctor

Take a family member or friend along, if possible, to help you remember the information you're given.

For postherpetic neuralgia, questions to ask your doctor include:

  • What's likely causing my symptoms?
  • What else could cause my symptoms?
  • What tests do I need?
  • Is my condition likely temporary or chronic?
  • What's the best course of action?
  • What are the alternatives to the primary approach you're suggesting?
  • I have other health conditions. How can I best manage them together?
  • Are there restrictions I need to follow?
  • Should I see a specialist?
  • Are there brochures or other printed material I can have? What websites do you recommend?

Don't hesitate to ask other questions.

What to expect from your doctor

Your doctor is likely to ask you several questions, such as:

  • Have your symptoms been continuous or occasional?
  • How severe are your symptoms?
  • Have you had chickenpox? When?
  • Have you had a shingles vaccine?
  • What, if anything, seems to improve your symptoms?
  • What, if anything, appears to worsen your symptoms?
Nov. 06, 2020
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  2. Bajwa ZH, et al. Postherpetic neuralgia. https://www.uptodate.com/contents/search. Accessed Oct. 9, 2018.
  3. Forstenpointner J, et al. Up-date on clinical management of postherpetic neuralgia and mechanism-based treatment: New options in therapy. The Journal of Infectious Diseases. 2018;218:S120.
  4. Mallick-Searle T, et al. Postherpetic neuralgia: Epidemiology, pathophysiology, and pain management pharmacology. Journal of Multidisciplinary Healthcare. 2016;9:447.
  5. Shingles: Clinical overview. Centers for Disease Control and Prevention. https://www.cdc.gov/shingles/hcp/clinical-overview.html. Accessed Oct. 9, 2018.
  6. Bubna AK. Aspirin in dermatology: Revisited. Indian Dermatology Online Journal. 2015:6:428.
  7. CDC guideline for prescribing opioids for chronic pain. Centers for Disease Control and Prevention. https://www.cdc.gov/drugoverdose/prescribing/guideline.html. Accessed Oct. 11, 2018.
  8. Watson JC. Expert opinion. Mayo Clinic, Rochester, Minn. Oct. 11, 2018.