Overview

Peripheral artery disease (also called peripheral arterial disease) is a common circulatory problem in which narrowed arteries reduce blood flow to your limbs.

When you develop peripheral artery disease (PAD), your legs or arms — usually your legs — don't receive enough blood flow to keep up with demand. This may cause symptoms, such as leg pain when walking (claudication).

Peripheral artery disease is also likely to be a sign of a buildup of fatty deposits in your arteries (atherosclerosis). This condition may narrow your arteries and reduce blood flow to your legs and, occasionally, your arms.

You often can successfully treat peripheral artery disease by exercising, eating a healthy diet and quitting tobacco in any form.

Symptoms

While many people with peripheral artery disease have mild or no symptoms, some people have leg pain when walking (claudication).

Claudication symptoms include muscle pain or cramping in your legs or arms that's triggered by activity, such as walking, but disappears after a few minutes of rest. The location of the pain depends on the location of the clogged or narrowed artery. Calf pain is the most common location.

The severity of claudication varies widely, from mild discomfort to debilitating pain. Severe claudication can make it hard for you to walk or do other types of physical activity.

Peripheral artery disease signs and symptoms include:

  • Painful cramping in one or both of your hips, thighs or calf muscles after certain activities, such as walking or climbing stairs
  • Leg numbness or weakness
  • Coldness in your lower leg or foot, especially when compared with the other side
  • Sores on your toes, feet or legs that won't heal
  • A change in the color of your legs
  • Hair loss or slower hair growth on your feet and legs
  • Slower growth of your toenails
  • Shiny skin on your legs
  • No pulse or a weak pulse in your legs or feet
  • Erectile dysfunction in men
  • Pain when using your arms, such as aching and cramping when knitting, writing or doing other manual tasks

If peripheral artery disease progresses, pain may even occur when you're at rest or when you're lying down. It may be intense enough to disrupt sleep. Hanging your legs over the edge of your bed or walking around your room may temporarily relieve the pain.

When to see a doctor

If you have leg pain, numbness or other symptoms, don't dismiss them as a normal part of aging. Call your doctor and make an appointment.

Even if you don't have symptoms of peripheral artery disease, you may need to be screened if you are:

  • Over age 65
  • Over age 50 and have a history of diabetes or smoking
  • Under age 50 and have diabetes and other peripheral artery disease risk factors, such as obesity or high blood pressure

Causes

Peripheral artery disease is often caused by atherosclerosis. In atherosclerosis, fatty deposits build up on your artery walls and reduce blood flow.

Although discussions of atherosclerosis usually focus on the heart, the disease can and usually does affect arteries throughout your body. When it occurs in the arteries supplying blood to your limbs, it causes peripheral artery disease.

Less commonly, the cause of peripheral artery disease may be blood vessel inflammation, injury to your limbs, unusual anatomy of your ligaments or muscles, or radiation exposure.

Risk factors

Factors that increase your risk of developing peripheral artery disease include:

  • Smoking
  • Diabetes
  • Obesity (a body mass index over 30)
  • High blood pressure
  • High cholesterol
  • Increasing age, especially after age 65 or after 50 if you have risk factors for atherosclerosis
  • A family history of peripheral artery disease, heart disease or stroke
  • High levels of homocysteine, an amino acid that helps your body make protein and to build and maintain tissue

People who smoke or have diabetes have the greatest risk of developing peripheral artery disease due to reduced blood flow.

Complications

If your peripheral artery disease is caused by a buildup of plaque in your blood vessels, you're also at risk of developing:

  • Critical limb ischemia. This condition begins as open sores that don't heal, an injury, or an infection of your feet or legs. Critical limb ischemia occurs when the injuries or infections progress and cause tissue death, sometimes requiring amputation of the affected limb.
  • Stroke and heart attack. The atherosclerosis that causes the signs and symptoms of peripheral artery disease isn't limited to your legs. Fat deposits also build up in arteries supplying blood to your heart and brain.

Prevention

The best way to prevent claudication is to maintain a healthy lifestyle. That means:

  • Quit smoking if you're a smoker.
  • If you have diabetes, keep your blood sugar in good control.
  • Exercise regularly. Aim for 30 to 45 minutes of exercise several times a week after you've gotten your doctor's OK.
  • Lower your cholesterol and blood pressure levels, if needed.
  • Eat foods that are low in saturated fat.
  • Maintain a healthy weight.

Peripheral artery disease (PAD) care at Mayo Clinic

Jan. 14, 2021
  1. Peripheral arterial disease. Merck Manual Professional Version. https://www.merckmanuals.com/professional/cardiovascular-disorders/peripheral-arterial-disorders/peripheral-arterial-disease. Accessed Oct. 14, 2020.
  2. Peripheral artery disease. National Heart, Lung, and Blood Institute. https://www.nhlbi.nih.gov/health-topics/peripheral-artery-disease. Accessed Oct. 14, 2020.
  3. Neschis DG, et al. Clinical features and diagnosis of lower extremity peripheral artery disease. https://www.uptodate.com/contents/search. Accessed Oct. 14, 2020.
  4. Prevention and treatment of PAD. American Heart Association. https://www.heart.org/en/health-topics/peripheral-artery-disease/prevention-and-treatment-of-pad Accessed Oct. 14, 2020.
  5. Gerhard-Herman MD, et al. 2016 AHA/ACC guideline on the management of patients with lower extremity peripheral artery disease: Executive summary. Vascular Medicine. 2017; doi:10.1177/1358863X17701592.
  6. Ferri FF. Peripheral artery disease. In: Ferri's Clinical Advisor 2021. Elsevier; 2021. https://www.clinicalkey.com. Accessed Oct. 14, 2020.
  7. Mankad R (expert opinion). Mayo Clinic, Rochester, Minn. May 4, 2018.
  8. Brown A. Allscripts EPSi. Mayo Clinic. Oct. 8, 2020.
  9. Davies MG. Management of claudication. https://www.uptodate.com/contents/search. Accessed Oct. 14, 2020.
  10. Harris L, et al. Epidemiology, risk factors, and natural history of peripheral artery disease. https://www.uptodate.com/contents/search. Accessed Oct. 14, 2020.
  11. Kashyap VS, et al. The LargPAD Trial: Phase IIA evaluation of L-arginine infusion in patients with peripheral arterial disease. Journal of Vascular Surgery. 2017; doi:10.1016/j.jvs.2016.12.127.
  12. Whelton PK, et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: A report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Hypertension. 2018; doi:10.1161/HYP.0000000000000065.
  13. Hoffman R, et al. Peripheral artery disease. In: Hematology: Basic Principles and Practice. 7th ed. Elsevier; 2018. https://www.clinicalkey.com. Accessed Oct. 14, 2020.
  14. Bjarnason H (expert opinion). Mayo Clinic. Oct. 15, 2020.