Diagnosis

Pancreatic cysts are diagnosed more often than in the past because improved imaging technology finds them more readily. Many pancreatic cysts are found during abdominal scans for other problems.

After taking a medical history and performing a physical exam, your doctor may recommend imaging tests to help with diagnosis and treatment planning. Tests include:

  • Computerized tomography (CT) scan. This imaging test can provide detailed information about the size and structure of a pancreatic cyst.
  • MRI scan. This imaging test can highlight subtle details of a pancreatic cyst, including whether it has any components that suggest a higher risk of cancer.
  • Endoscopic ultrasound. This test, like an MRI, can provide a detailed image of the cyst. Also, fluid can be collected from the cyst for analysis in a laboratory for possible signs of cancer.
  • Magnetic resonance cholangiopancreatography (MRCP). MRCP is considered the imaging test of choice for monitoring a pancreatic cyst. This type of imaging is especially helpful for evaluating cysts in the pancreatic duct.

The characteristics and location of the pancreatic cyst, along with your age and sex, can sometimes help doctors determine the type of cyst you have:

  • Pseudocysts are not cancerous (benign) and are usually caused by pancreatitis. Pancreatic pseudocysts can also be caused by trauma.
  • Serous cystadenomas can become large enough to displace nearby organs, causing abdominal pain and a feeling of fullness. Serous cystadenomas occur most frequently in women older than 60 and only rarely become cancerous.
  • Mucinous cystic neoplasms are usually situated in the body or tail of the pancreas and nearly always occurs in women, most often in middle-aged women. Mucinous cystadenoma is precancerous, which means it might become cancer if left untreated. Larger cysts might already be cancerous when found.
  • An intraductal papillary mucinous neoplasm (IPMN) is a growth in the main pancreatic duct or one of its side branches. IPMN may be precancerous or cancerous. It can occur in both men and women older than 50. Depending on its location and other factors, IPMN may require surgical removal.
  • Solid pseudopapillary neoplasms are usually situated in the body or tail of the pancreas and occur most often in women younger than 35. They are rare and sometimes cancerous.
  • A cystic neuroendocrine tumor is mostly solid but can have cystlike components. They can be confused with other pancreatic cysts and may be precancerous or cancerous.

Treatment

Watchful waiting or treatment depends on the type of cyst you have, its size, its characteristics and whether it's causing symptoms.

Watchful waiting

A benign pseudocyst, even a large one, can be left alone as long as it isn't bothering you. Serous cystadenoma rarely becomes cancerous, so it also can be left alone unless it causes symptoms or grows. Some pancreatic cysts should be monitored.

Drainage

A pseudocyst that is causing bothersome symptoms or growing larger can be drained. A small flexible tube (endoscope) is passed through your mouth to your stomach and small intestine. The endoscope is equipped with an ultrasound probe (endoscopic ultrasound) and a needle to drain the cyst. Sometimes drainage through the skin is necessary.

Surgery

Some types of pancreatic cysts require surgical removal because of the risk of cancer. Surgery might be needed to remove an enlarged pseudocyst or a serous cystadenoma that's causing pain or other symptoms.

A pseudocyst may recur if you have ongoing pancreatitis.

Clinical trials

Explore Mayo Clinic studies testing new treatments, interventions and tests as a means to prevent, detect, treat or manage this disease.

Preparing for your appointment

Here's some information to help you get ready for your appointment.

What you can do

  • Write down your symptoms, including when they started and whether they've changed or worsened over time.
  • Write down key personal information, including a history of injury to your abdomen.
  • Make a list of all medications, vitamins and supplements you take.
  • Write down questions to ask your doctor.

Some basic questions include:

  • What is the most likely cause of my condition?
  • What tests do I need?
  • What type of cyst do I have?
  • Is it likely to become cancerous?
  • If I need surgery, what will my recovery be like?
  • What follow-up care will I need?
  • I have other conditions. How can I manage them together?

Don't hesitate to ask other questions, as well.

What to expect from your doctor

Your doctor is likely to ask you questions about your symptoms, such as:

  • When did your symptoms begin?
  • Have your symptoms been continuous or occasional?
  • How severe are your symptoms?
  • Where do you feel your symptoms the most?
  • What, if anything, seems to improve your symptoms?
  • What, if anything, seems to worsen your symptoms?
  • Have you had pancreatitis?
  • How many alcoholic drinks do you consume daily?
  • Do you have gallstones?
Feb. 28, 2020
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  2. Basar O, et al. My treatment approach: Pancreatic cysts. Mayo Clinic Proceedings. 2017;92:1519.
  3. Khalid A, et al. Classification of pancreatic cysts. https://www.uptodate.com/contents/search. Accessed May 10, 2019.
  4. Brewer Guttierez OI, et al. Pancreatic cysts: Sinister findings or incidentalomas? Medical Clinics of North America. 2019;103:163.
  5. Rocha R, et al. Spontaneous rupture of pancreatic pseudocyst: Report of two cases. Case Reports in Surgery. 2016. doi:10.1155/2016/7056567.
  6. AskMayoExpert. Pancreatic cystic lesions (adult). Mayo Clinic. 2019.
  7. Rajan E (expert opinion). Mayo Clinic. May 27, 2019.