Overview

Neuromyelitis optica (NMO) is a central nervous system disorder that primarily affects the eye nerves (optic neuritis) and the spinal cord (myelitis). NMO is also known as neuromyelitis optica spectrum disorder or Devic's disease. It occurs when your body's immune system reacts against its own cells in the central nervous system, mainly in the optic nerves and spinal cord, but sometimes in the brain.

The cause of neuromyelitis optica is usually unknown, although it sometimes appears after an infection, or it can be associated with another autoimmune condition. Neuromyelitis optica is often misdiagnosed as multiple sclerosis (MS) or perceived as a type of MS, but NMO is a distinct condition.

Neuromyelitis optica can cause blindness in one or both eyes, weakness or paralysis in the legs or arms, painful spasms, loss of sensation, uncontrollable vomiting and hiccups, and bladder or bowel dysfunction from spinal cord damage. Children can have confusion, seizures or coma with NMO. Neuromyelitis optica flare-ups might be reversible, but they can be severe enough to cause permanent visual loss and problems with walking.

Neuromyelitis optica care at Mayo Clinic

Dec. 10, 2020
  1. Weinshenker BG, et al. Neuromyelitis spectrum disorders. Mayo Clinic Proceedings. 2017;92:663.
  2. Daroff RB, et al. Multiple sclerosis and other inflammatory demyelinating diseases of the central nervous system. In: Bradley's Neurology in Clinical Practice. 7th ed. Elsevier; 2016. https://www.clinicalkey.com. Accessed Nov. 23, 2020.
  3. Yanoff M, et al., eds. Inflammatory optic neuropathies and neuroretinitis. In: Ophthalmology. 5th ed. Elsevier Inc.; 2019. https://www.clinicalkey.com. Accessed Nov. 23, 2020.
  4. Glisson CC. Neuromyelitis optica spectrum disorders. https://www.uptodate.com/contents/search. Accessed Nov. 23, 2020.
  5. Symptoms and diagnosis of NMO. National Multiple Sclerosis Society. http://www.nationalmssociety.org/What-is-MS/Related-Conditions/Neuromyelitis-Optica-(NMO)/Symptoms-and-Diagnosis. Accessed Sept. 10, 2017.
  6. Wingerechuk DM, et al. Revised diagnostic criteria for neuromyelitis optica. Neurology. 2006;66:1485.
  7. Riggin EA. Allscripts EPSi. Mayo Clinic. Oct. 23, 2020.

Related

Associated Procedures