Multiple endocrine neoplasia, type 1 (MEN 1), sometimes called Wermer's syndrome, is a rare disorder that causes tumors in the endocrine glands and parts of the small intestine and stomach. In MEN 1, the endocrine glands — usually the parathyroids, pancreas and pituitary — grow tumors and release excessive amounts of hormones that can lead to disease. However, the tumors are usually noncancerous (benign).
The excess hormones can cause a wide variety of signs and symptoms. These can include tiredness, bone pain, broken bones, kidney stones, and ulcers in the stomach or intestines. MEN 1 can't be cured. But regular testing can detect problems, and doctors can provide treatment as needed.
MEN 1 is an inherited disorder. This means people who have the gene mutation can pass it on to their children. Each child has a 50% chance of inheriting the disorder.
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Signs and symptoms of MEN 1 include the following:
- Bone pain
- Broken bones
- Kidney stones
- Ulcers in the stomach or intestines
Symptoms are caused by the release of too many hormones in the body.
Multiple endocrine neoplasia, type 1 (MEN 1) care at Mayo Clinic
Oct. 29, 2021
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Multiple endocrine neoplasia, type 1 (MEN 1)