Multiple endocrine neoplasia, type 1 (MEN 1)

Overview

Multiple endocrine neoplasia, type 1 (MEN 1), sometimes called Wermer's syndrome, is a rare disorder that causes tumors in the endocrine glands and parts of the small intestine and stomach. In MEN 1, the endocrine glands — usually the parathyroids, pancreas and pituitary — grow tumors and release excessive amounts of hormones that can lead to disease. However, the tumors are usually noncancerous (benign).

The excess hormones can cause a wide variety of signs and symptoms. These can include tiredness, bone pain, broken bones, kidney stones, and ulcers in the stomach or intestines. MEN 1 can't be cured. But regular testing can detect problems, and doctors can provide treatment as needed.

MEN 1 is an inherited disorder. This means people who have the gene mutation can pass it on to their children. Each child has a 50% chance of inheriting the disorder.

Symptoms

Signs and symptoms of MEN 1 include the following:

• Tiredness
• Bone pain
• Broken bones
• Kidney stones
• Ulcers in the stomach or intestines

Symptoms are caused by the release of too many hormones in the body.