Multiple endocrine neoplasia, type 1 (MEN 1), sometimes called Wermer's syndrome, is a rare disorder that causes tumors in the endocrine glands and parts of the small intestine and stomach. In MEN 1, the endocrine glands — usually the parathyroids, pancreas and pituitary — grow tumors and release excessive amounts of hormones that can lead to disease. However, the tumors are usually noncancerous (benign).
The excess hormones can cause a wide variety of signs and symptoms. These can include tiredness, bone pain, broken bones, kidney stones, and ulcers in the stomach or intestines. MEN 1 can't be cured. But regular testing can detect problems, and doctors can provide treatment as needed.
MEN 1 is an inherited disorder. This means people who have the gene mutation can pass it on to their children. Each child has a 50% chance of inheriting the disorder.
Products & Services
Signs and symptoms of MEN 1 include the following:
- Bone pain
- Broken bones
- Kidney stones
- Ulcers in the stomach or intestines
Symptoms are caused by the release of too many hormones in the body.
Multiple endocrine neoplasia, type 1 (MEN 1) care at Mayo Clinic
Nov. 26, 2020
- Jameson JL, et al., eds. Multiple endocrine neoplasia type 1. In: Endocrinology: Adult and Pediatric. 7th ed. Saunders Elsevier; 2016. https://www.clinicalkey.com. Accessed Oct. 11, 2020.
- Melmed S, et al. Multiple endocrine neoplasia. In: Williams Textbook of Endocrinology. 14th ed. Elsevier; 2020. https://www.clinicalkey.com. Accessed Oct. 11, 2020.
- Multiple endocrine neoplasia type 1. National Institute of Diabetes and Digestive and Kidney Diseases. https://www.niddk.nih.gov/health-information/endocrine-diseases/multiple-endocrine-neoplasia-type-1. Accessed Oct. 11, 2020.
- Warner K. Allscripts EPSi. Mayo Clinic. Oct. 26, 2020.
- Multiple endocrine neoplasia, type 1 (MEN 1). Merck Manual Professional Version. https://www.merckmanuals.com/professional/endocrine-and-metabolic-disorders/multiple-endocrine-neoplasia-men-syndromes/multiple-endocrine-neoplasia,-type-1-men-1. Accessed Oct. 11, 2020.
- Arnold A. Multiple endocrine neoplasia type 1: Treatment. https://www.uptodate.com/contents/search. Accessed Oct. 11, 2020.
- Kearns AE (expert opinion). Mayo Clinic. Oct. 30, 2020.
- Kamilaris CDC, et al. Multiple endocrine neoplasia type 1 (MEN1): An update and the significance of early genetic and clinical diagnosis. Frontiers in Endocrinology. 2019; doi: 10.3389/fendo.2019.00339.
Products & Services
Multiple endocrine neoplasia, type 1 (MEN 1)