Severe cases of hemophilia usually are diagnosed within the first year of life. Mild forms might not be apparent until adulthood. Some people learn they have hemophilia after they bleed excessively during a surgical procedure.

Clotting-factor tests can reveal a clotting-factor deficiency and determine how severe the hemophilia is.

For people with a family history of hemophilia, genetic testing might be used to identify carriers to make informed decisions about becoming pregnant.

It's also possible to determine during pregnancy if the fetus is affected by hemophilia. However, the testing poses some risks to the fetus. Discuss the benefits and risks of testing with your doctor.


The main treatment for severe hemophilia involves replacing the clotting factor you need through a tube in a vein.

This replacement therapy can be given to treat a bleeding episode in progress. It can also be given on a regular schedule at home to help prevent bleeding episodes. Some people receive continuous replacement therapy.

Replacement clotting factor can be made from donated blood. Similar products, called recombinant clotting factors, are made in a laboratory, not from human blood.

Other therapies include:

  • Desmopressin. In some forms of mild hemophilia, this hormone can stimulate the body to release more clotting factor. It can be injected slowly into a vein or used as a nasal spray.
  • Emicizumab (Hemlibra). This is a newer drug that doesn't include clotting factors. This drug can help prevent bleeding episodes in people with hemophilia A.
  • Clot-preserving medications. Also known as anti-fibrinolytics, these medications help prevent clots from breaking down.
  • Fibrin sealants. These can be applied directly to wound sites to promote clotting and healing. Fibrin sealants are especially useful for dental work.
  • Physical therapy. It can ease signs and symptoms if internal bleeding has damaged your joints. Severe damage might require surgery.
  • First aid for minor cuts. Using pressure and a bandage will generally take care of the bleeding. For small areas of bleeding beneath the skin, use an ice pack. Ice pops can be used to slow down minor bleeding in the mouth.

Clinical trials

Explore Mayo Clinic studies testing new treatments, interventions and tests as a means to prevent, detect, treat or manage this condition.

Lifestyle and home remedies

To avoid excessive bleeding and protect your joints:

  • Exercise regularly. Activities such as swimming, bicycle riding and walking can build muscles while protecting joints. Contact sports — such as football, hockey or wrestling — are not safe for people with hemophilia.
  • Avoid certain pain medications. Drugs that can make bleeding worse include aspirin and ibuprofen (Advil, Motrin IB, others). Instead, use acetaminophen (Tylenol, others), which is a safer alternative for mild pain relief.
  • Avoid blood-thinning medications. Medications that prevent blood from clotting include heparin, warfarin (Jantoven), clopidogrel (Plavix), prasugrel (Effient), ticagrelor (Brilinta), rivaroxaban (Xarelto), apixaban (Eliquis), edoxaban (Savaysa) and dabigatran (Pradaxa).
  • Practice good dental hygiene. The goal is to prevent tooth and gum disease, which can lead to excessive bleeding.
  • Get vaccinations. People with hemophilia should receive recommended vaccinations at the appropriate ages, as well as hepatitis A and B. Requesting use of the smallest gauge needle and having pressure or ice applied for 3 to 5 minutes after the injection can reduce the risk of bleeding.
  • Protect your child from injuries that could cause bleeding. Kneepads, elbow pads, helmets and safety belts all help prevent injuries from falls and other accidents. Keep your home free of furniture with sharp corners.

Coping and support

To help you and your child cope with hemophilia:

  • Get a medical alert bracelet. This lets medical personnel know that you or your child has hemophilia, and the type of clotting factor that's best in case of an emergency.
  • Talk with a counselor. Striking the right balance between keeping your child safe and encouraging as much activity as possible can be tricky. A social worker or therapist with knowledge of hemophilia can help identify the least amount of limitations your child needs.
  • Let people know. Be sure to tell anyone who will be taking care of your child — babysitters, child care workers, relatives, friends and teachers — about your child's condition. If your child plays noncontact sports, be sure to tell coaches, too.

Preparing for your appointment

If you or your child has signs or symptoms of hemophilia, you might be referred to a doctor who specializes in blood disorders (hematologist).

What you can do

Make a list of:

  • Symptoms and when they began
  • Key medical information, including other conditions, and a family history of bleeding disorders
  • All medications, vitamins and supplements, including doses

Questions to ask your doctor

  • What's the most likely cause of these signs and symptoms?
  • What tests are needed? Do they require special preparation?
  • What treatment do you recommend?
  • What activity restrictions are recommended?
  • What is the risk of long-term complications?
  • Do you recommend that our family meet with a genetic counselor?

Don't hesitate to ask other questions, as well.

What to expect from your doctor

Your doctor is likely to ask you a number of questions, including:

  • Have you noticed any unusual or heavy bleeding, such as nosebleeds or prolonged bleeding from a cut or vaccination?
  • If you or your child has had surgery, did the surgeon mention excessive bleeding?
  • Are you or your child prone to developing large, deep bruises?
  • Do you or your child have pain or warmth around joints?
Aug. 29, 2023

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  1. Bleeding disorders. National Heart, Lung, and Blood Institute. https://www.nhlbi.nih.gov/health-topics/bleeding-disorders. Accessed June 10, 2021.
  2. AskMayoExpert. Hemophilia. Mayo Clinic; 2021.
  3. Hoots WK, et al. Hemophilia A and B: Routine management including prophylaxis. https://www.uptodate.com/contents/search. Accessed June 10, 2021.
  4. Hemophilia. Merck Manual Professional Version. https://www.merckmanuals.com/professional/hematology-and-oncology/coagulation-disorders/hemophilia?query=hemophilia#. Accessed June 10, 2021.
  5. Weyand AC, et al. New therapies for hemophilia. Blood. 2019; doi:10.1182/blood-2018-08-872291.
  6. What is hemophilia? Centers for Disease Control and Prevention. https://www.cdc.gov/ncbddd/hemophilia/facts.html. Accessed June 10, 2021.
  7. Hoots WK, et al. Treatment of bleeding and perioperative management in hemophilia A and B. https://www.uptodate.com/contents/search. Accessed June 10, 2021.
  8. Morrow ES. Allscripts EPSi. Mayo Clinic. April 14, 2021.


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