In corticobasal degeneration, areas of your brain (including the cerebral cortex and basal ganglia) shrink and your nerve cells degenerate and die over time. This degeneration results in growing difficulty in movement on one or both sides of your body.

The condition may cause you to have poor coordination, stiffness, thinking (cognitive) difficulties, speech or language difficulty, or other problems.


Symptoms of corticobasal degeneration include difficulty moving on one or both sides of the body. Movement gets more difficult over time. Other symptoms include poor coordination and stiffness. Trouble with thinking, speech, and language may also occur.

Clinical trials

Explore Mayo Clinic studies testing new treatments, interventions and tests as a means to prevent, detect, treat or manage this disease.

Corticobasal degeneration care at Mayo Clinic

Dec. 20, 2018
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