A diagnosis of corticobasal degeneration (corticobasal syndrome) is made based on your symptoms, exam and testing. However, your symptoms could be due to another disease that affects the brain. Conditions that cause similar symptoms include progressive supranuclear palsy, Alzheimer's disease, Pick's disease or Creutzfeldt-Jakob disease.

You may need an imaging test such as an MRI or CT scan to rule out these other conditions. Sometimes, these tests are performed every few months to look for changes in the brain.

Positron emission tomography (PET) scans can identify brain changes related to corticobasal degeneration. However, more research needs to be done in this area.

Your healthcare professional may test your blood or cerebrospinal fluid for amyloid and tau proteins. This can determine whether Alzheimer's disease is the cause of your symptoms.


There are no treatments that help slow the progression of corticobasal degeneration (corticobasal syndrome). But if your symptoms are due to Alzheimer's disease, new medicines may be available. Your healthcare professional may recommend medicines to try to manage your symptoms.

Occupational and physical therapy may help you manage the disabilities caused by corticobasal degeneration. Walking devices may help with mobility and prevent falls. Speech therapy can help with communication and swallowing. A dietitian may help you ensure you get proper nutrition and lower the risk of inhaling food into the lungs, known as aspiration.

Preparing for your appointment

You may start by seeing your healthcare professional. Or you may be referred immediately to a specialist, such as a neurologist.

Here's some information to help you get ready for your appointment.

What you can do

When you make the appointment, ask if there's anything you need to do in advance. For example, you might ask if you need to fast before a specific test. Make a list of:

  • Your symptoms, including any that seem unrelated to the reason for your appointment.
  • Key personal information, including major stresses, recent life changes and family medical history.
  • All medicines, vitamins or other supplements you take, including the doses.
  • Questions to ask.

Take a family member or friend along to help you remember the information you're given.

For corticobasal degeneration, some basic questions to ask include:

  • What's likely causing my symptoms?
  • Other than the most likely cause, what are other possible causes for my symptoms?
  • What tests do I need?
  • Is my condition likely temporary or chronic?
  • What's the best course of action?
  • What are the alternatives to the primary approach you're suggesting?
  • I have these other health conditions. How can I best manage them together?
  • Are there restrictions I need to follow?
  • Should I see a specialist?
  • Are there brochures or other printed material I can have? What websites do you recommend?

Don't hesitate to ask other questions.

What to expect from your doctor

Your healthcare professional is likely to ask you several questions, such as:

  • When did your symptoms begin?
  • Have your symptoms been continuous or occasional?
  • How bad are your symptoms?
  • What, if anything, seems to improve your symptoms?
  • What, if anything, appears to worsen your symptoms?

Corticobasal degeneration (corticobasal syndrome) care at Mayo Clinic

Dec. 22, 2023
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  2. Ropper AH, et al. Degenerative diseases of the nervous system. In: Adams and Victor's Principles of Neurology. 12th ed. McGraw Hill; 2023. https://accessmedicine.mhmedical.com. Accessed Oct. 25, 2023.
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Corticobasal degeneration (corticobasal syndrome)