To diagnose chronic hives, your health care provider will likely talk with you about your symptoms and look at your skin. One of the telling features of chronic hives is that the welts come and go at random. You might be asked to keep a diary to keep track of:

  • Your activities
  • Any medications, herbal remedies or supplements you take
  • What you eat and drink
  • Where hives appear and how long it takes a welt to fade and whether it leaves behind a bruise or other mark
  • Whether your hives come with painful swelling

You may also need blood tests to determine the cause of your symptoms. An accurate diagnosis will guide your treatment options. If needed to clarify the diagnosis, your doctor might take a skin sample (biopsy) to examine under a microscope.

More Information


Treatment for chronic hives often starts with nonprescription anti-itch drugs (antihistamines). If these don't help, your health care provider might suggest that you try one or more of these treatments:

Prescription anti-itch drugs. The usual treatment for chronic hives is prescription antihistamine pills that don't make you drowsy. These drugs ease itching, swelling and other allergy symptoms. Daily use of these drugs helps block the symptom-producing release of histamine. Examples include:

  • Cetirizine
  • Desloratadine (Clarinex)
  • Fexofenadine

These medications have few side effects. If the nondrowsy antihistamines don't help you, your health care provider may increase the dose or add another type of antihistamine.

Check with your health care provider before taking any of these medications if you're pregnant or breastfeeding, have a long-term medical condition, or take other medications.

Other medications

If the first-choice drugs don't ease your symptoms, other drugs may help. For example:

  • Famotidine (Pepcid AC)
  • Montelukast (Singulair)
  • Doxepin (Silenor, Zonalon)
  • Cimetidine (Tagamet HB)
  • Nizatidine (Axid AR)
  • Ranitidine (Zantac)
  • Omalizumab (Xolair)

For chronic hives that resist these treatments, your health care provider might prescribe a drug that can calm an overactive immune system. Examples are cyclosporine (Gengraf, Neoral, Sandimmune), tacrolimus (Prograf, Protopic, others), hydroxychloroquine (Plaquenil) and mycophenolate (Cellcept, Myfortic).

Clinical trials

Explore Mayo Clinic studies testing new treatments, interventions and tests as a means to prevent, detect, treat or manage this condition.

Lifestyle and home remedies

Chronic hives can go on for months and years. They can interfere with sleep, work and other activities. The following self-care tips may help you manage your condition:

  • Avoid triggers. These can include foods, medications, pollen, pet dander, latex and insect stings. If you think a medication caused your welts, stop using it and contact your primary care provider. Some studies suggest that stress or fatigue can trigger hives.
  • Use a nonprescription anti-itch drug. A nonprescription anti-itch (antihistamine) pill that doesn't cause drowsiness may help ease itching. Examples include loratadine (Alavert, Claritin, others) and cetirizine (Zyrtec Allergy).
  • Apply cold. Soothe the skin by covering the itchy area with a cold washcloth or rubbing an ice cube over it for a few minutes.
  • Take a comfortably cool shower or bath. Some people might relieve itching in the short term by taking a cool shower or bath. Try sprinkling the bath water with baking soda or oatmeal powder (Aveeno, others).
  • Apply an anti-itch cream or lotion. Try a cream with menthol for a soothing effect.
  • Wear loose, smooth-textured cotton clothing. Avoid wearing clothing that's rough, tight, scratchy or made from wool.
  • Protect your skin from the sun. Liberally apply sunscreen about a half hour before going outdoors. When outdoors, seek shade to help relieve discomfort.
  • Track your symptoms. Keep a diary of when and where hives occur, what you were doing, what you were eating, and so on. This may help you and your health care provider identify triggers.

Preparing for your appointment

You'll likely start by seeing your primary care provider. Or you may be referred to an allergy specialist or a doctor who specializes in the diagnosis and treatment of skin conditions (dermatologist).

What you can do

Here are some tips to help you get ready for your appointment.

  • List your symptoms, when they occurred and how long they lasted.
  • List any medications you're taking, including vitamins, herbs and supplements. Even better, take the original bottles and a list of the doses and directions.
  • List questions to ask your doctor.

For chronic hives, questions you may want to ask include:

  • What is likely causing my symptoms?
  • How long will hives last?
  • What kinds of tests do I need? Do these tests require any special preparation?
  • What treatments are available, and which do you suggest?
  • What are the alternatives to the primary approach that you're suggesting?
  • Do these treatments have any side effects?
  • Do I need prescription medication, or can I use nonprescription drugs to treat the condition?
  • Does the medicine you're prescribing have a generic version?

What to expect from your doctor

Your health care provider is likely to ask you a few questions, such as:

  • When did you first have symptoms?
  • What did your skin reaction look like when it first appeared?
  • Have your symptoms changed over time?
  • Have you noticed anything that makes your symptoms worse or better?
  • Do your skin lesions mainly itch, or do they burn or sting?
  • Do your skin lesions go away completely without leaving a bruise or a mark?
  • Do you have any known allergies?
  • Have you ever had a similar skin reaction before?
  • Have you tried a new food for the first time, changed laundry products or adopted a new pet?
  • What prescriptions, nonprescription medications and supplements are you taking?
  • Have you started taking any new medications or started a new course of a medication you've taken before?
  • Has your overall health changed recently? Have you had any fevers or have you lost weight?
  • Has anyone else in your family ever had this kind of skin reaction? Do other family members have any known allergies?
  • What at-home treatments have you used?
April 25, 2023
  1. AskMayoExpert. Urticaria Mayo Clinic; 2021.
  2. Bernstein JA, et al., eds. The diagnosis and management of acute and chronic urticarial: 2014 update. Journal of Allergy and Clinical Immunology. 2014; doi:10.1016/j.jaci.2014.02.036.
  3. Kang S, et al., eds. Urticaria and angioedema. In: Fitzpatrick's Dermatology. 9th ed. McGraw-Hill; 2019. https://accessmedicine.mhmedical.com. Accessed Aug. 29, 2019.
  4. Hives (urticaria). American College of Allergy, Asthma, and Immunology. http://acaai.org/allergies/types/skin-allergies/hives-urticaria. Accessed March 28, 2022.
  5. Thompson DA. Hives. In: Adult Telephone Protocols: Office Version. 5th ed. American Academy of Pediatrics; 2022.
  6. Briggs JK. Hives. In: Triage Protocols for Aging Adults. Wolters Kluwer; 2019.
  7. Ferri FF. Urticaria. In: Ferri's Clinical Advisor 2022. Elsevier; 2022. https://www.clinicalkey.com. Accessed Aug. 4, 2021.
  8. Hives. American Academy of Dermatology. https://www.aad.org/public/diseases/a-z/hives-treatment. Accessed March 28, 2022.
  9. Kelly AP, et al., eds. Drug eruptions. In: Taylor and Kelly's Dermatology for Skin of Color. 2nd ed. McGraw Hill; 2016. https://accessmedicine.mhmedical.com. Accessed Aug. 4, 2021.


Associated Procedures

Products & Services