Cholecystitis (ko-luh-sis-TIE-tis) is inflammation of the gallbladder. The gallbladder is a small, pear-shaped organ on the right side of the belly (abdomen), beneath the liver. The gallbladder holds a digestive fluid (bile) that's released into the small intestine.

In most cases, gallstones blocking the tube leading out of the gallbladder cause cholecystitis. This results in a bile buildup that can cause inflammation. Other causes of cholecystitis include bile duct problems, tumors, serious illness and certain infections.

If left untreated, cholecystitis can lead to severe, sometimes life-threatening complications, such as a gallbladder rupture. Treatment for cholecystitis often involves surgery to remove the gallbladder.


Symptoms of cholecystitis may include:

  • Severe pain in your upper right or center abdomen
  • Pain that spreads to your right shoulder or back
  • Tenderness over your abdomen when it's touched
  • Nausea
  • Vomiting
  • Fever

Cholecystitis symptoms often occur after a meal, particularly a large or fatty one.

When to see a doctor

Make an appointment with your health care provider if you have symptoms that worry you. If your abdominal pain is so severe that you can't sit still or get comfortable, have someone drive you to the emergency room.

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Cholecystitis is when your gallbladder is inflamed. Gallbladder inflammation can be caused by:

  • Gallstones. Most often, cholecystitis is the result of hard particles that develop in your gallbladder (gallstones). Gallstones can block the tube (cystic duct) through which bile flows when it leaves the gallbladder. Bile builds up in the gallbladder, causing inflammation.
  • Tumor. A tumor may prevent bile from draining out of your gallbladder properly. This causes bile buildup that can lead to cholecystitis.
  • Bile duct blockage. Stones or thickened bile and tiny particles (sludge) can block the bile duct and lead to cholecystitis. Kinking or scarring of the bile ducts can also cause blockage.
  • Infection. AIDS and certain viral infections can trigger gallbladder inflammation.
  • Severe illness. Very severe illness can damage blood vessels and decrease blood flow to the gallbladder, leading to cholecystitis.

Risk factors

Having gallstones is the main risk factor for developing cholecystitis.


If untreated, cholecystitis can lead to a number of serious complications, including:

  • Infection within the gallbladder. If bile builds up within your gallbladder, causing cholecystitis, the bile may become infected.
  • Death of gallbladder tissue. Untreated cholecystitis can cause tissue in the gallbladder to die (gangrene). It's the most common complication, especially among older people, those who wait to get treatment and those with diabetes. This can lead to a tear in the gallbladder, or it may cause your gallbladder to burst.
  • Torn gallbladder. A tear (perforation) in your gallbladder may result from gallbladder swelling, infection or death of tissue.


You can reduce your risk of cholecystitis by taking the following steps to prevent gallstones:

  • Lose weight slowly. Rapid weight loss can increase the risk of gallstones.
  • Maintain a healthy weight. Being overweight makes you more likely to develop gallstones. To achieve a healthy weight, reduce calories and increase your physical activity. Maintain a healthy weight by continuing to eat well and exercise.
  • Choose a healthy diet. Diets high in fat and low in fiber may increase the risk of gallstones. To lower your risk, choose a diet high in fruits, vegetables and whole grains.

Sept. 09, 2022
  1. Ferri FF. Cholecystitis. In: Ferri's Clinical Advisor 2023. Elsevier; 2023. https://www.clinicalkey.com. Accessed July 11, 2022.
  2. Sanford DE. An update on technical aspects of cholecystectomy. Surgical Clinic of North America. 2019; doi:10.1016/j.suc.2018.11.005.
  3. Acute cholecystitis. Merck Manual Professional Version. https://www.merckmanuals.com/professional/hepatic-and-biliary-disorders/gallbladder-and-bile-duct-disorders/acute-cholecystitis. Accessed June 16, 2022.
  4. Gallstones. National Institute of Diabetes and Digestive and Kidney Diseases. https://www.niddk.nih.gov/health-information/digestive-diseases/gallstones/all-content. Accessed June 16, 2022.
  5. Afdhal NH. Acalculous cholecystitis: Clinical manifestations, diagnosis, and management. https://www.uptodate.com/contents/search. Accessed June 17, 2022.
  6. Zakko SF, et al. Acute calculous cholecystitis: Clinical features and diagnosis. https://www.uptodate.com/contents/search. Accessed June 17, 2022.
  7. Vollmer CM, et al. Treatment of acute calculous cholecystitis. https://www.uptodate.com/contents/search. Accessed June 17, 2022.
  8. AskMayoExpert. Biliary stone disease. Mayo Clinic; 2021.
  9. Miura F, et al. Tokyo Guidelines 2018: Initial management of acute biliary infection and flowchart for acute cholangitis. Journal of Hepato-Biliary-Pancreatic Science. 2018; doi:10.1002/jhbp.509.
  10. Rajan E (expert opinion). Mayo Clinic. July 10, 2022.


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