Amyotrophic lateral sclerosis (ALS)

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Displaying 11-19 out of 19 doctors available

  1. James B. Meiling, D.O.

    James B. Meiling, D.O.

    1. Physiatrist
    2. Electrodiagnostic Physician
    3. Neuromuscular Disease Specialist
    1. Rochester, MN
    Areas of focus:

    Nerve block, Ultrasound, Ultrasound-guided injection, Electromyography, Ultrasound-guided musculoskeletal injection, Ne...rve hydrodissection, Musculoskeletal ultrasound, Pediatric needle electromyography, Pediatric neuromuscular ultrasound, Ultrasound-guided needle electromyography, Single-fiber electromyography, Diaphragmatic ultrasound, Ultrasound-guided cortisone injection, Nerve conduction study, Neuromuscular ultrasound, Upper extremity functional restoration, Amyotrophic lateral sclerosis, Carpal tunnel syndrome, Thumb arthritis, Brachial plexus injury, Brachial plexus neuropathy, Cubital tunnel syndrome, Neuropathy, Guillain Barre syndrome, Trigger finger, Nerve entrapment, de Quervain's tenosynovitis, Ulnar wrist pain, Neuromuscular disorder, Inclusion body myositis, Charcot-Marie-Tooth disease, Ganglion cyst, Peripheral nerve injury, Muscular dystrophy, Hand injury, Basal joint arthritis, Ulnar nerve entrapment, Parsonage-Turner syndrome, Nerve compression syndrome, Hand arthritis, Median neuropathy, Radial neuropathy, Motor neuron disease, Myopathy, Ulnar neuropathy, Mononeuropathies, Wrist osteoarthritis

  2. Margherita Milone, M.D., Ph.D.

    Margherita Milone, M.D., Ph.D.

    1. Neurologist
    1. Rochester, MN
    Areas of focus:

    Amyotrophic lateral sclerosis, Mitochondrial disease, Myasthenia gravis, Primary lateral sclerosis, Muscular dystrophy,... Motor neuron disease

  3. Elie Naddaf, M.D.

    Elie Naddaf, M.D.

    1. Neurologist
    1. Rochester, MN
    Areas of focus:

    Electromyography, Amyotrophic lateral sclerosis, Dermatomyositis, Myasthenia gravis, Peripheral neuropathy, Chronic inf...lammatory demyelinating polyneuropathy, Neuromuscular disorder, POEMS syndrome, Myositis, Inclusion body myositis, Polymyositis, Nemaline myopathy, Primary lateral sclerosis, Muscular dystrophy, Mitochondrial myopathy

  4. Bjorn E. Oskarsson, M.D.

    Bjorn E. Oskarsson, M.D.

    1. Neurologist
    2. Neuromuscular Disease Specialist
    1. Jacksonville, FL
    Areas of focus:

    Lumbar puncture, Amyotrophic lateral sclerosis, Primary lateral sclerosis, Motor neuron disease

  5. Duygu Selcen, M.D.

    Duygu Selcen, M.D.

    1. Neurologist
    1. Rochester, MN
    Areas of focus:

    Amyotrophic lateral sclerosis, Dermatomyositis, Myasthenia gravis, Peripheral neuropathy, Muscle weakness, Juvenile der...matomyositis, Neuromuscular disorder, Myositis, Charcot-Marie-Tooth disease, Polymyositis, Primary lateral sclerosis, Muscular dystrophy, Duchenne muscular dystrophy, Scapuloperoneal muscular dystrophy, Juvenile motor neuron disease, Juvenile amyotrophic lateral sclerosis, Myotonic dystrophy, Spinal muscular atrophy, Facioscapulohumeral muscular dystrophy, Motor neuron disease, Limb girdle muscular dystrophy, Mitochondrial myopathy, Myopathy, Congenital myasthenic syndrome, Cramp-fasciculation syndrome, Neuromyotonia, Lambert-Eaton myasthenic syndrome, Childhood Lambert-Eaton syndrome

  6. Eric J. Sorenson, M.D.

    Eric J. Sorenson, M.D.

    1. Neurologist
    1. Rochester, MN
    Areas of focus:

    Electromyography, Neurological examination, Amyotrophic lateral sclerosis, Cerebral palsy, Primary lateral sclerosis

  7. Nathan P. Staff, M.D., Ph.D.

    Nathan P. Staff, M.D., Ph.D.

    1. Neurologist
    1. Rochester, MN
    Areas of focus:

    Electromyography, Amyotrophic lateral sclerosis, Brachial plexus neuropathy, Diabetic neuropathy, Neuropathy, Guillain ...Barre syndrome, Peripheral neuropathy, POEMS syndrome, Charcot-Marie-Tooth disease, Primary lateral sclerosis, Spinal and bulbar muscular atrophy, Lumbosacral plexopathy, Chronic inflammatory demyelinating polyradiculoneuropathy, Motor neuron disease, Mononeuritis multiplex, Paraneoplastic syndromes of the nervous system, Progressive bulbar palsy, Hereditary neuropathy

  8. Derek W. Stitt, M.D.

    Derek W. Stitt, M.D.

    1. Neurologist
    1. Rochester, MN
    Areas of focus:

    Amyotrophic lateral sclerosis, Seizure , Dementia, Migraine, Migraine with aura, Parkinson's disease, Multiple sclerosi...s, Peripheral neuropathy, Absence seizure, Primary lateral sclerosis, Medication overuse headache, Neurosarcoidosis, Tonic-clonic seizure, Frontal lobe seizure

  9. James C. Watson, M.D.

    James C. Watson, M.D.

    1. Neurologist
    1. Rochester, MN
    Areas of focus:

    Cancer treatment, Injection, Fluoroscopy, Radiofrequency ablation, Spine procedure, Pain management, Botox injection, N...erve block, Spinal injection, Ultrasound, Joint injection, Stellate ganglion block, Lumbar sympathetic block, Epidural blood patch, Ablation therapy, Trigger point injection, Radiofrequency neurotomy, Medial branch block, Celiac plexus block, Ultrasound-guided injection, Electromyography, Ultrasound-guided cortisone injection, Fluoroscopy-guided biopsy, Epidural steroid injection, Sympathetic nerve block, Amyotrophic lateral sclerosis, Back pain, Myasthenia gravis, Herniated disk, Primary lateral sclerosis

Research

Mayo Clinic is on the forefront of researching a cure for ALS. Researchers at Mayo Clinic study the possible causes of ALS. This includes identifying biomarkers in blood and cerebrospinal fluid that might someday help to identify and monitor loss of motor neurons in ALS. The biomarkers also may help monitor response to treatment.

Mayo Clinic research also includes finding genes that might cause or contribute to getting ALS. Together with teams at other institutions, Mayo Clinic researchers discovered the C9orf72 hexanucleotide repeat expansion (C9), a gene variation that can cause ALS and frontotemporal dementia. This gene variation is the most common cause of ALS. The discovery allowed Mayo Clinic researchers to find a way to predict ALS and other brain aging conditions.

Research at Mayo Clinic into the genetic aspects of the disease is ongoing. It's hoped that future discoveries lead researchers to find new, effective treatments for people with ALS. Find out more about ALS research at Mayo Clinic in the Department of Neurology Research.

ALS Gene

Vivien Williams: In this lab, Dr. Rosa Rademakers and her team have been on a quest to find a cause of two deadly diseases - Lou Gehrig's disease or ALS and frontotemporal dementia or FTD, which is a type of dementia unlike Alzheimer's disease in that it causes personality changes not memory loss.

Rosa Rademakers, Ph.D., Neuroscience Research, Mayo Clinic: It was really kind of a race to try and find this.

Vivien Williams: For four years, they studied the genetic information of families who had ALS and FTD.

Dr. Rademakers: One day, we were looking at the computer screen and all of sudden there was this special pattern that was only present in the patients and not present in the healthy individuals. And at that moment, we knew that this was very likely to be it.

Vivien Williams: A never before seen genetic mutation.

Dr. Rademakers: And you can see that this pattern here, where the peaks are big and then they are small. This strange pattern is not present in the two healthy individuals.

Vivien Williams: Dr. Rademakers says before her discovery there were some genes found that were thought to cause about 20% of all ALS and FTD cases, but her discovery explains even more - up to half of all ALS cases and about 1/3 of all FTD cases.

Dr. Rademakers: Every time we identify a new gene, we understand a little bit more about what it is that's causing the disease in these patients. What it is that makes these brain cells die.

Vivien Williams: Dr. Rademakers says this discovery will open avenues of research that may one day lead to effective therapies to help improve and prolong the lives of victims of these diseases.

Dr. Rademakers: Our hope is that we find methods to identify who will develop the disease, so that we can interfere with it before it's too late, before the important brain cells have died.

Vivien Williams: For Mayo Clinic News Network, I'm Vivien Williams.

In addition, Mayo Clinic researchers study potential new treatments for people with ALS and ALS-related diseases. They also participate in clinical trials of potential new medicines.

To create effective treatments, researchers need to better understand ALS. There are many projects available to people with ALS to volunteer and donate blood and spinal fluid to help find a cure.

Find out more about ALS clinical trials at Mayo Clinic.

Publications

See a list of publications about ALS by Mayo Clinic doctors on PubMed, a service of the National Library of Medicine.

Research Profiles

By Mayo Clinic Staff

Amyotrophic lateral sclerosis (ALS) care at Mayo Clinic

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Diagnosis & treatmentCare at Mayo Clinic
May 06, 2026
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Amyotrophic lateral sclerosis (ALS)

Research: It's all about patients

[MUSIC PLAYING]

Joseph Sirven, M.D., Professor of Neurology, Mayo Clinic: Mayo's mission is about the patient. The patient comes first. So the mission and research here is to advance how we can best help the patient, how to make sure the patient comes first in care. So in many ways, it's a cycle. It can start with as simple as an idea worked on in a laboratory, brought to the patient bedside, and if everything goes right — and let's say it's helpful or beneficial — then brought on as a standard approach. And I think that is one of the unique characteristics of Mayo's approach to research — that patient-centeredness — that really helps to put it in its own spotlight.