Amyotrophic lateral sclerosis, known as ALS, can be hard to diagnose early because it can have symptoms similar to other diseases. Tests to rule out other conditions or help diagnose ALS might include:

  • Electromyogram (EMG). A needle is inserted through the skin into various muscles. The test records the electrical activity of the muscles when they contract and when they're at rest. This can determine if there is a problem with the muscles or nerves.
  • Nerve conduction study. This study measures your nerves' ability to send impulses to muscles in different areas of the body. This test can determine if you have nerve damage. EMG and nerve conduction studies are almost always done together.
  • MRI. Using radio waves and a powerful magnetic field, an MRI produces detailed images of the brain and spinal cord. An MRI can reveal spinal cord tumors, herniated disks in the neck or other conditions that might be causing your symptoms. The highest resolution cameras may sometimes see ALS changes themselves.
  • Blood and urine tests. Analyzing samples of your blood and urine in the laboratory might help eliminate other possible causes of your symptoms. Serum neurofilament light levels, which are measured from blood samples, are generally high in people with ALS. The test can help make a diagnosis early in the disease.
  • Spinal tap, known as a lumbar puncture. This involves removing a sample of spinal fluid for laboratory testing. Spinal fluid is removed using a small needle inserted between two bones in the lower back. The spinal fluid appears typical in people with ALS but may uncover another cause of symptoms.
  • Muscle biopsy. If your health care provider believes you may have a muscle disease rather than ALS, you might undergo a muscle biopsy. While you're under local anesthesia, a small piece of muscle is removed and sent to a lab for analysis.
  • Nerve biopsy. If your health care provider believes you may have a nerve disease rather than ALS, you might undergo a nerve biopsy. While you're under local anesthesia, a small piece of nerve is removed and sent to a lab for analysis.


Treatments can't reverse the damage of ALS, but they can slow the progression of symptoms. They also can help prevent complications and make you more comfortable and independent.

You might need a team of health care providers and doctors trained in many areas to provide your care. The team works together to prolong your survival and improve your quality of life.

Your team works to select the right treatments for you. You have the right to choose or refuse any of the treatments suggested.


The Food and Drug Administration has approved two medicines for treating ALS:

  • Riluzole (Rilutek, Exservan, Tiglutik). Taken by mouth, this medicine can increase life expectancy by about 25%. It can cause side effects such as dizziness, gastrointestinal conditions and liver problems. Your health care provider typically monitors your liver function with periodic blood draws while you're taking the medicine.
  • Edaravone (Radicava). This medicine may reduce the speed of decline in daily functioning. It's given through a vein in your arm or by mouth as a liquid. The effect on life span isn't yet known. Side effects can include bruising, headache and trouble walking. This medicine is given daily for two weeks each month.

Your health care provider also might prescribe treatments for relief of other symptoms, including:

  • Muscle cramps and spasms.
  • Constipation.
  • Fatigue.
  • Excessive saliva and phlegm.
  • Pain.
  • Depression.
  • Sleep problems.
  • Uncontrolled outbursts of laughing or crying.
  • An urgent need to urinate.
  • Leg swelling.


When ALS affects your ability to breathe, speak and move, therapies and other forms of support can help.

  • Breathing care. Most people with ALS eventually have more trouble breathing as muscles weaken. Your health care provider might test your breathing regularly and provide devices known as mechanical ventilation to assist your breathing at night.

    You might choose to use a ventilator with a mask that can easily be applied and removed. This is known as noninvasive ventilation. Some people eventually have surgery that creates a hole at the front of the neck leading to their windpipe. This is called a tracheostomy. A tube inserted into the hole connects to a respirator to help them breathe. Sometimes people with ALS who have a tracheostomy also have a type of surgery called a laryngectomy. This surgery prevents food from entering the lungs.

  • Physical therapy. A physical therapist can address pain, walking, mobility, bracing and equipment needs that help you stay independent. Practicing low-impact exercises can help maintain your cardiovascular fitness, muscle strength and range of motion for as long as possible.

    Regular exercise also can help improve your sense of well-being. Appropriate stretching can help prevent pain and help your muscles function at their best.

    A physical therapist also can help you overcome weakness by using a brace, walker or wheelchair. The therapist might suggest devices such as ramps that make it easier for you to get around.

  • Occupational therapy. An occupational therapist can help you find ways to remain independent despite hand and arm weakness. Adaptive equipment can help you perform activities such as dressing, grooming, eating and bathing.

    An occupational therapist also can help you modify your home to allow accessibility if you have trouble walking safely.

  • Speech therapy. A speech therapist can teach you adaptive techniques to make your speech more understandable. Speech therapists also can help you find other ways to communicate. These may include using a smart phone app, alphabet board, or pen and paper.

    Ask your therapist about the possibility of recording your own voice to be used by a text-to-speech application.

  • Nutritional support. Your team typically works with you and your family members to ensure you are eating foods that are easier to swallow and meet your nutritional needs. You might choose to have a feeding tube placed when it becomes too hard to swallow.
  • Psychological and social support. Your team might include a social worker to help with financial issues, insurance, and getting equipment and paying for devices you need. Psychologists, social workers and others may provide emotional support for you and your family.

Potential future treatments

Based on the current understanding of ALS, researchers are conducting clinical studies on promising medicines and treatments.

Clinical trials

Explore Mayo Clinic studies testing new treatments, interventions and tests as a means to prevent, detect, treat or manage this condition.

Coping and support

Learning you have ALS can be devastating. The following tips may help you and your family cope:

  • Take time to grieve. The news that you have a fatal condition that reduces your mobility and independence is hard to hear. You and your family may go through a period of mourning and grief after diagnosis.
  • Be hopeful. Your team can help you focus on your abilities and healthy living. Some people with ALS live much longer than the 3 to 5 years usually associated with this condition. Some live 10 years or more. Maintaining an optimistic outlook can help improve quality of life for people with ALS.
  • Think beyond the physical changes. Many people with ALS lead rewarding lives despite physical limitations. Try to think of ALS as only one part of your life, not your entire identity.
  • Join a support group. You might find comfort in a support group with others who have ALS. Loved ones helping with your care might benefit from a support group of other ALS caregivers. Find support groups in your area by talking to your doctor or by contacting the ALS Association.
  • Make decisions now about your future medical care. Planning for the future allows you to be in control of decisions about your life and your care. It also lessens the burden for your loved ones. With the help of your health care provider, hospice nurse or social worker, you can decide whether you want certain life-extending procedures.

    You also can decide where you want to spend your final days. You might consider hospice care options. Planning for the future can help you and your loved ones calm anxieties.

  • Considering getting involved in ALS research. ALS research is working toward finding a cure for ALS. Consider joining a clinical trial, providing samples for research and joining the National ALS Registry. The registry is open to all people with ALS. Many institutions collect samples for research to better understand the disease.

Preparing for your appointment

Your primary care provider may be the first to recognize the symptoms of ALS. Your provider will likely refer you to a doctor trained in nervous system conditions, known as a neurologist, to establish a diagnosis.

What you can do

You might need many tests to diagnose your condition. The diagnosis process can be stressful and frustrating. These strategies might give you a greater sense of control.

  • Keep a symptom diary. Before you see a neurologist, start using a calendar or notebook to jot down when and how you notice symptoms. Record information about your problems with walking, hand coordination, speech, swallowing or involuntary muscle movements. Your notes might show a pattern that's helpful for your diagnosis.
  • Find a neurologist and care team. An integrated care team led by your neurologist usually is most appropriate for ALS care. Your team typically communicates with each other and is familiar with your needs.

What to expect from your doctor

Your primary care provider will likely review your family's medical history and your symptoms. Your neurologist and your primary care provider might conduct a physical and neurological exam. This might include testing your:

  • Reflexes.
  • Muscle strength.
  • Muscle tone.
  • Senses of touch and sight.
  • Coordination.
  • Balance.

Amyotrophic lateral sclerosis (ALS) care at Mayo Clinic

April 10, 2024
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