Treatment at Mayo Clinic

By Mayo Clinic Staff


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Mayo Clinic doctors trained in treating children who have brain and nervous system conditions (pediatric neurologists), doctors trained in brain and nervous system conditions (neurologists), and others work together to determine the most appropriate treatment for people who have adrenoleukodystrophy (ALD).

Adrenoleukodystrophy has no cure. However, stem cell transplantation may stop the progression of ALD if done when neurological symptoms first appear. Doctors will focus on relieving your symptoms and slowing disease progression.

Your treatment options may include:

  • Stem cell transplant. This may be an option to slow or halt the progression of adrenoleukodystrophy in children if the disease is diagnosed and treated early. Stem cells may be taken from bone marrow through bone marrow transplant.
  • Adrenal insufficiency treatment. Many people who have ALD develop adrenal insufficiency and need to have regular adrenal gland testing. Adrenal insufficiency can be treated effectively with steroids (corticosteroid replacement therapy).
  • Medications. Your doctor may prescribe medications to help relieve symptoms, including stiffness and seizures.
  • Physical therapy. Physical therapy may help relieve muscle spasms and reduce muscle rigidity. Your doctor will recommend wheelchairs and other mobility devices if needed.
  • Genetic counseling. Your treatment may include genetic counseling for you and your family. Mayo Clinic doctors trained in hereditary conditions (neurometabolic specialists) explain your diagnosis and the role of genes in your condition. Doctors strongly recommend that you and your family receive genetic testing and counseling.
Dec. 12, 2014