Neurosurgery

Below are current clinical trials.

Filter this list of studies by location, status and more.

1. A Registry to Follow Long-Term Outcomes for Mother and Child Pairs After Fetal Surgery for Spina Bifida

   Rochester, Minn.

   The purpose of this study is to form a registry of data on the long term physical and mental health outcomes of the mother and child following fetal surgical repair for spina bifida.

2. A Study to Evaluate the Safety and Effectiveness of the Spineology Interbody Fusion System in Lumbar Fusion Procedures

   Rochester, Minn.

   The purpose of this study is to evaluate the safety and effectiveness of the Spineology Interbody Fusion System (SIFS) mesh device when implanted in the spinal vertebrae disc space during a lumbar fusion procedure.

3. Clinical Impact of Cortex Stimulation

   Rochester, Minn.

   The purpose of this study is to examine the long term effects of motor cortex stimulation related to pain control.

    

4. Acupuncture For The Treatment of Autonomic Dysfunction

   Jacksonville, Fla.

   The purpose of this study is to demonstrate the benefits of acupuncture in patients who have refractory autonomic dysfunction, including nausea, emesis, ileus, diabetic gastroparesis, failure to thrive.

5. Cortical versus Pedicle Screw Stimulation Thresholds and Accuracy

   Rochester, Minn.

   The purpose of this study is to compare the stimulation threshold and accuracy of pedicle versus cortical trajectory screws

6. Functional Magnetic Resonance Imaging (fMRI) During Deep Brain Stimulation (DBS) to Treat Parkinson's Disease

   Jacksonville, Fla., Rochester, Minn.

   This study is investigating the usefulness of using functional magnetic resonance imaging (fMRI) to monitor brain activation during deep brain stimulation for Parkinson's Disease. The study may determine the relationship between patterns of brain activation and therapeutic outcome and/or side effects.

7. Viral Therapy in Treating Patients with Recurrent Glioblastoma Multiforme

   Rochester, Minn.

   RATIONALE: Vaccines made from a gene-modified virus may help the body build an effective immune response to kill tumor cells.

   PURPOSE: This phase I trial is studying the side effects and best dose of viral therapy in treating patients with recurrent glioblastoma multiforme.

8. Investigation of Regulatory Genes in Pathophysiology of Craniosynostosis

   Rochester, Minn.

   The purpose of this study is to collect tissue (during the initial procedure only) that is surgically removed (and routinely discarded at Mayo Clinic) from CS patients. Portions of the tissue will be embedded in plastic for histological and histomorphometric analysis. A small portion of the tissue will be used for outgrowth cultures to isolate cells. Nucleic acid and protein will be extracted from the remaining portions of the tissue and/or isolated cell lines to examine candidate genes and their role in the disease process.

9. The Epidemiology, Process and Outcomes of Spine Oncology (EPOSO)

   Rochester, Minn.

   The main purpose of this study is to utilize a comprehensive, prospective clinical database to collect patient, diagnostic and treatment variables along with disease specific and generic health related quality of life (HRQOL) data on consecutively treated patients with metastatic spine tumors. The objectives are to determine the validity and reliability of the Spine Cancer Outcomes Questionnaire (SCOQ) for use in the assessment of spine tumor outcomes, to determine if the Spine Instability Neoplastic Score (SINS) Classification is a valid tool for predicting the stability of spine in metastatic spine disease, and to determine the efficacy of surgery versus radiotherapy for the treatment of impending instability secondary to metastatic disease of the spine.

10. A Study of Swallowing Problems and Aspiration Risks in Elderly Patients with Cervical Spine Fractures

    Rochester, Minn.

    The purpose of this study is to determine the incidence of swallowing disorders and the risk for aspiration in elderly patients who have cervical spine fractures.