Familial Hypercholesterolemia Clinic Overview

Mayo Clinic doctors trained in heart disease (cardiologists) have experience and expertise evaluating and treating people with familial hypercholesterolemia and other inherited lipid disorders. People with these conditions are at high risk for heart attacks and recurrent heart attacks. Cardiologists and other staff in this clinic work closely with you to develop an individualized treatment plan.

Familial hypercholesterolemia is a fairly common inherited condition that puts people at increased risk of coronary heart disease.


In the Familial Hypercholesterolemia Clinic, cardiologists trained in the diagnosis and treatment of inherited lipid disorders will provide you with a comprehensive assessment and conduct diagnostic tests to determine the most appropriate therapy for you.

Your cardiologist works with a multidisciplinary team, including genomic cardiologists, genetic counselors, nurse practitioners, exercise specialists and nutritionists, that specializes in helping you with inherited lipid disorders and heart health. If you need a consultation for a related medical condition, doctors from many areas can be brought together to examine your condition.

Conditions diagnosed and treated at the Familial Hypercholesterolemia Clinic include:

  • Familial hypercholesterolemia
  • Familial hypertriglyceridemia
  • Familial combined hyperlipidemia
  • Elevated lipoprotein A
  • Sitosterolemia

Your comprehensive care plan may involve the following services:

  • Exercise prescription
  • Nutrition counseling
  • Electrocardiogram, echocardiogram
  • Advanced cardiovascular biomarker testing, including C-reactive protein, lipoprotein A, ceramides, homocysteine, lipoprotein subfractionation
  • Arterial function tests
  • Heart scan for calcification
  • Genetic testing for familial hyperlipidemia syndromes
  • Genetic counseling
  • Cardiology consultation
  • Lipid-lowering therapy, including statins, ezetimide and PCSK9 inhibitors
  • Invasive cardiovascular testing and therapy, including coronary angiography, percutaneous coronary interventions


The experts of the Mayo Clinic Familial Hypercholesterolemia Clinic conduct research to establish new best practices for the treatment of familial hypercholesterolemia.


You may be referred by your primary doctor, or you may make an appointment without a referral. Not all services may be available at all locations. Please confirm when you request an appointment.

July 23, 2022