Familial Hypercholesterolemia Clinic Overview

The Familial Hypercholesterolemia Clinic at Mayo Clinic in Rochester, Minnesota, is staffed by doctors trained in heart disease (cardiologists) who have deep expertise in evaluating and treating people with familial hypercholesterolemia and other inherited lipid disorders. People with these conditions are at high risk of heart attacks and recurrent heart attacks. Cardiologists and other medical professionals in this clinic work closely with you to develop a treatment plan tailored to your needs and goals.


In the Familial Hypercholesterolemia Clinic, your cardiologist works with a multidisciplinary team, including genomic cardiologists, genetic counselors, nurse practitioners, exercise specialists and dietitians. If you need help with a related medical condition, doctors from other areas may be brought into the discussion.

Conditions diagnosed and treated at the Familial Hypercholesterolemia Clinic include:

  • Familial hypercholesterolemia.
  • Familial hypertriglyceridemia.
  • Familial combined hyperlipidemia.
  • Elevated lipoprotein (a).
  • Sitosterolemia.

Your comprehensive care plan may involve the following services:

  • Exercise prescription.
  • Nutrition counseling.
  • Electrocardiogram, echocardiogram.
  • Advanced cardiovascular biomarker testing, including C-reactive protein, lipoprotein (a), ceramides, homocysteine, lipoprotein subfractionation.
  • Arterial function tests.
  • Heart scan for calcification.
  • Genetic testing for familial hyperlipidemia syndromes.
  • Genetic counseling.
  • Cardiology consultation.
  • Lipid-lowering therapy, including statins, ezetimibe (Zetia) and PCSK9 inhibitors.
  • Invasive cardiovascular testing and therapy, such as coronary angiography and percutaneous coronary interventions.

Innovative research

The experts of the Mayo Clinic Familial Hypercholesterolemia Clinic conduct research to establish best practices for the treatment of familial hypercholesterolemia. And they created a web-based tool designed to enhance communication among family members about the condition and the need for testing. It's called FH Family Share.


You may be referred to the Familial Hypercholesterolemia Clinic by your primary doctor, or you may make an appointment yourself.

Nationally recognized expertise

Mayo Clinic is top-ranked in more specialties than any other hospital and has been recognized as an Honor Roll member according to the U.S. News & World Report's 2023-2024 "Best Hospitals" rankings.

Mayo Clinic campuses are nationally recognized for expertise in cardiology and cardiovascular surgery:

  • Mayo Clinic in Rochester, Minn., Mayo Clinic in Phoenix/Scottsdale, Ariz., and Mayo Clinic in Jacksonville, Fla., are ranked among the Best Hospitals for heart and heart surgery by U.S. News & World Report.
  • Mayo Clinic Children's Center in Rochester is ranked the No. 1 hospital in Minnesota, and the five-state region of Iowa, Minnesota, North Dakota, South Dakota and Wisconsin, according to U.S. News & World Report's 2023–2024 "Best Children's Hospitals" rankings.



  • Mayo Clinic Familial Hypercholesterolemia Clinic
  • 200 First St. SW
    Rochester, MN 55905
  • Phone: 507-284-3994
Nov. 02, 2023