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Ernesto Ayala, M.D.

Ernesto Ayala, M.D. is a hematologist and oncologist in the Department of Internal Medicine at Mayo Clinic hospital in Jacksonville, Florida. He specializes in stem cell transplantation for the treatment of benign and malignant hematologic conditions and the treatment of lymphoma. He also applies new immunotherapies including CAR T-Cell Therapy for the treatment of advanced lymphoma, and has interest in the use of autologous transplantation for the treatment of severe autoimmune disorders such as scleroderma and multiple sclerosis.

Dr. Ayala — who is bilingual, and speaks Spanish and English — earned his Doctor of Medicine degree from the Universidad Nacional de Colombia, and completed his residency and Hematology/Oncology fellowship through the University of Miami/Jackson Memorial Hospital. Soon after, he completed his second fellowship in Bone Marrow Transplantation at Moffitt Cancer Center and Research Institute, where he also spearheaded the Haploidentical Transplantation Program prior to joining Mayo Clinic.

"I am very passionate about what I do and I always try to be in tune with my patients when they come to me with complex medical conditions," Dr. Ayala says. Hands-on training throughout his educational career has enabled him to provide high-quality, patient-centered care. He incorporates the most advanced treatments possible, such as immunotherapy, in his care plans.

Dr. Ayala dedicates his free time to volunteering in underserved clinics, and enjoys cycling and swimming.

  • Allogeneic and autologous transplantation for hematologic disorders
  • Haploidentical transplantation
  • Lymphoma
  • CAR T-Cell Therapy
  • Transplantation for autoimmune disorders
  1. 2004
    Fellowship - Blood and Marrow Transplantation H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida
  2. 2003
    Fellowship - Hematology/OncologyUniversity of Miami/Jackson Memorial Hospital
  3. 2000
    Residency - Internal MedicineUniversity of Miami/Jackson Memorial Hospital
  4. 1993
    Residency - Internal Medicine/Medical OncologyInstituto Nacional de Cancerologia
  5. 1985
    MDUniversidad Nacional de Colombia


  1. 2004
    HematologyAmerican Board of Internal Medicine
  2. 2003
    Medical OncologyAmerican Board of Internal Medicine
  3. 2000
    Internal MedicineAmerican Board of Internal Medicine

Awards and honors

  1. 2004
    Travel AwardAmerican Society for Blood and Marrow Transplantation
  2. 2000
    Best Teaching ResidentInternal Medicine Program, University of Miami

Professional memberships

  1. 2020 - present
    Assistant Program DirectorHematology/Oncology Fellowship Program, Division of Hematology/Oncology, Department of Internal Medicine
  2. 2020 - present
    Medical DirectorAmbulatory Infusion Center
  3. 2016 - present
    ParticipantGuidelines Committee, American Society for Blood and Marrow Transplantation
  4. 2016 - 2018
    Member/RepresentativeFaculty Council, Moffitt Cancer Center, Morsani College of Medicine
  5. 2015 - present
    MemberAmerican Society of Bone Marrow Transplantation
  6. 2013 - 2018
    MemberMedical Institutional Review Board, University of South Florida
  7. 2009 - 2018
    MemberProtocol Monitoring Committee, Moffitt Cancer Center
  8. 2008 - present
    MemberLymphoma Working Committee, Center for International Bone Marrow Transplantation Research
  9. 2002 - present
    Active MemberAmerican Society of Clinical Oncology
  10. 2002 - present
    Active MemberAmerican Society of Hematology