Print Allogeneic stem cell transplantAn allogeneic stem cell transplant uses healthy blood stem cells from a donor to replace bone marrow that's not producing enough healthy blood cells. An allogeneic stem cell transplant is also called an allogeneic bone marrow transplant. Bone marrow transplants for adults and children may involve of use of one’s own cells (autologous transplant), cells from a donor (allogeneic transplant) or cells from an umbilical cord (cord blood transplant). The blood stem cells used in an allogeneic stem cell transplant can be: Collected from the donor's blood Collected from the bone marrow within a donor's hipbone Collected from the blood of a donated umbilical cord Before undergoing an allogeneic stem cell transplant, you'll receive high doses of chemotherapy or radiation to destroy your diseased cells and prepare your body for the donor cells. There is a problem with information submitted for this request. 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Sorry something went wrong with your subscription Please, try again in a couple of minutes Retry Why it's doneAn allogeneic stem cell transplant may be an option for people with a variety of cancerous and noncancerous diseases, including: Acute leukemia Adrenoleukodystrophy Aplastic anemia Bone marrow failure syndromes Chronic leukemia Hemoglobinopathies Hodgkin's lymphoma Immune deficiencies Inborn errors of metabolism Multiple myeloma Myelodysplastic syndromes Neuroblastoma Non-Hodgkin's lymphoma Plasma cell disorders POEMS syndrome Primary amyloidosis What you can expectUndergoing an allogeneic stem cell transplant involves: Undergoing high doses of cancer treatment (conditioning). During the conditioning process, you'll receive high doses of chemotherapy or radiation therapy to kill your cancer cells. What treatment you undergo depends on your disease and your particular situation. The cancer treatments used during the conditioning process carry a risk of side effects. Talk with your doctor about what you can expect from your treatment. Receiving an infusion of stem cells. Stem cells from a donor will be infused into your bloodstream, where they will travel to your bone marrow and begin creating new blood cells. Remaining under close medical care. After your transplant your care team will want to monitor you carefully for signs of complications. You may spend a few weeks in the hospital or nearby. Expect to undergo frequent blood tests and appointments to monitor your body's response to the transplant. It takes a few weeks for the donor cells to settle in your bone marrow and begin making new cells. You may receive blood transfusions until your bone marrow recovers. By Mayo Clinic Staff Request an appointment March 28, 2024 Print Show references Blood and marrow stem cell transplantation guide. Leukemia & Lymphoma Society. https://www.lls.org/resource-center/download-or-order-free-publications. Accessed Jan. 27, 2022. Blood and bone marrow transplant. National Heart, Lung, and Blood Institute. https://www.nhlbi.nih.gov/health-topics/blood-and-bone-marrow-transplant. Accessed Jan. 27, 2022. Diseases treatable by transplants. National Marrow Donor Program. https://bethematch.org/transplant-basics/how-transplants-work/diseases-treatable-by-transplants/. Accessed Jan. 27, 2022. AskMayoExpert. Hematopoietic stem cell transplant. Mayo Clinic; 2020. 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There is a problem with information submitted for this request. Review/update the information highlighted below and resubmit the form. Get Mayo Clinic cancer expertise delivered to your inbox. Subscribe for free and receive an in-depth guide to coping with cancer, plus helpful information on how to get a second opinion. You can unsubscribe at any time. Click here for an email preview. Email address I would like to learn more about Up-to-date cancer news & research Mayo Clinic cancer care & management options ErrorSelect a topic ErrorEmail field is required ErrorInclude a valid email address Address 1 Subscribe Learn more about Mayo Clinic’s use of data. To provide you with the most relevant and helpful information, and understand which information is beneficial, we may combine your email and website usage information with other information we have about you. If you are a Mayo Clinic patient, this could include protected health information. If we combine this information with your protected health information, we will treat all of that information as protected health information and will only use or disclose that information as set forth in our notice of privacy practices. You may opt-out of email communications at any time by clicking on the unsubscribe link in the e-mail. Thank you for subscribing Your in-depth coping with cancer guide will be in your inbox shortly. You will also receive emails from Mayo Clinic on the latest about cancer news, research, and care. If you don’t receive our email within 5 minutes, check your SPAM folder, then contact us at newsletters@mayoclinic.com. Sorry something went wrong with your subscription Please, try again in a couple of minutes Retry