Most of the time fatigue can be traced to one or more of your habits or routines, particularly lack of exercise. It's also commonly related to depression. On occasion, fatigue is a symptom of other underlying conditions that require medical treatment.

Lifestyle factors

Taking an honest inventory of things that might be responsible for your fatigue is often the first step toward relief. Fatigue may be related to:

  1. Use of alcohol or drugs
  2. Excess physical activity
  3. Jet lag
  4. Lack of physical activity
  5. Lack of sleep
  6. Medications, such as antihistamines, cough medicines
  7. Unhealthy eating habits


Unrelenting exhaustion may be a sign of a condition or an effect of the drugs or therapies used to treat it, such as:

  1. Anemia
  2. Anxiety
  3. Cancer
  4. Chronic fatigue syndrome
  5. Chronic infection or inflammation
  6. Chronic kidney disease
  7. COPD
  8. Depression (major depressive disorder)
  9. Diabetes
  10. Emphysema
  11. Meralgia paresthetica
  12. Grief
  13. Heart disease
  14. Hyperthyroidism (overactive thyroid)
  15. Hypothyroidism (underactive thyroid)
  16. Inflammatory bowel disease (IBD)
  17. Medications and treatments, such as chemotherapy, radiation therapy, pain drugs, heart drugs and antidepressants
  18. Multiple sclerosis
  19. Obesity
  20. Pain that's persistent
  21. Sleep apnea
  22. Stress
  23. Toxin ingestion

Causes shown here are commonly associated with this symptom. Work with your doctor or other health care professional for an accurate diagnosis.

Feb. 02, 2016