Red wine and resveratrol: Good for your heart?
Red wine and something in red wine called resveratrol might be heart healthy. Find out the facts, and hype, regarding red wine and its impact on your heart.By Mayo Clinic Staff
Red wine, in moderation, has long been thought of as heart healthy. The alcohol and certain substances in red wine called antioxidants may help prevent heart disease by increasing levels of high-density lipoprotein (HDL) cholesterol (the "good" cholesterol) and protecting against artery damage.
While the news about red wine might sound great if you enjoy a glass of red wine with your evening meal, doctors are wary of encouraging anyone to start drinking alcohol. That's because too much alcohol can have many harmful effects on your body.
Still, many doctors agree that something in red wine appears to help your heart. It's possible that antioxidants, such as flavonoids or a substance called resveratrol, have heart-healthy benefits.
How is red wine heart healthy?
Red wine seems to have even more heart-healthy benefits than do other types of alcohol, but it's possible that red wine isn't any better than beer, white wine or liquor for heart health. There's still no clear evidence that red wine is better than other forms of alcohol when it comes to possible heart-healthy benefits.
Antioxidants in red wine called polyphenols may help protect the lining of blood vessels in your heart. A polyphenol called resveratrol is one substance in red wine that's gotten attention.
Resveratrol in red wine
Resveratrol might be a key ingredient in red wine that helps prevent damage to blood vessels, reduces low-density lipoprotein (LDL) cholesterol (the "bad" cholesterol) and prevents blood clots.
Most research on resveratrol has been done on animals, not people. Research in mice given resveratrol suggests that the antioxidant might also help protect them from obesity and diabetes, both of which are strong risk factors for heart disease. However, those findings were reported only in mice, not in people. In addition, to get the same dose of resveratrol used in the mice studies, a person would have to drink more than 1,000 liters of red wine every day. Research in pigs has shown that resveratrol may improve heart function and increase the body's ability to use insulin. Again, however, these benefits have not been tested in people.
Some research shows that resveratrol could be linked to a reduced risk of inflammation and blood clotting, both of which can lead to heart disease. More research is needed before it's known whether resveratrol was the cause for the reduced risk. However, one study showed that resveratrol may actually reduce the positive effect of exercise on the heart in older men. It's also important to know that resveratrol's effects only last a short time after drinking red wine, so its effects may not last in the long term.
Apr. 25, 2014
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- Alcohol and heart disease. American Heart Association. http://www.heart.org/HEARTORG/Conditions/More/MyHeartandStrokeNews/Alcohol-and-Heart-Disease_UCM_305173_Article.jsp. Accessed Sept. 5, 2013.
- Saremi A, et al. The cardiovascular implications of alcohol and red wine. American Journal of Therapeutics. 2008;15:265.
- Tome-Carneiro J, et al. Resveratrol in primary and secondary prevention of cardiovascular disease: A dietary and clinical perspective. Annals of the New York Academy of Sciences. 2013;1290:37.
- Huang PH, et al. Intake of red wine increases the number and functional capacity of circulating endothelial progenitor cells by enhancing nitric oxide bioavailability. Arteriosclerosis, Thrombosis, and Vascular Biology. 2010;30:869.
- Tangney CC, et al. Cardiovascular benefits and risks of moderate alcohol consumption. http://www.uptodate.com/home. Accessed Sept. 3, 2013.
- Gresele P, et al. Resveratrol, at concentrations attainable with moderate wine consumption, stimulates human platelet nitric oxide production. Journal of Nutrition. 2008;138:1602.
- Costanzo S, et al. Cardiovascular and overall mortality in relation to alcohol consumption in patients with cardiovascular disease. Circulation. 2010;121:1951.
- Your guide to lowering blood pressure: Limit alcohol intake. National Heart, Lung, and Blood Institute. http://www.nhlbi.nih.gov/hbp/prevent/l_alcohol/l_alcohol.htm. Accessed Sept. 5, 2013.
- Resveratrol. Linus Pauling Institute at Oregon State Unversity. http://lpi.oregonstate.edu/infocenter/phytochemicals/resveratrol/. Accessed Sept. 5, 2013.
- Resveratrol. Natural Medicines Comprehensive Database. http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=SCHOOLNOPL~AER&s=ND&pt=100&id=307&ds=. Accessed Sept. 5, 2013.
- Chiva-Blanch G, et al. Effects of wine, alcohol and polyphenols on cardiovascular disease risk factors: Evidences from human studies. Alcohol and Alcoholism. 2013;48:270-277.
- Gliemann L, et al. Resveratrol blunts the positive effects of exercise training on cardiovascular health in aged men. Journal of Physiology. 2013 Aug. 19.
- Carrizzo A, et al. Antioxidant effects of resveratrol in cardiovascular, cerebral and metabolic diseases. Food and Chemical Toxicology. 2013. In press. Accessed Sept. 5, 2013.
- Mukamal KJ, et al. Overview of the risks and benefits of alcohol consumption. http://www.uptodate.com/home. Accessed Sept. 3, 2013.
- Cottart CH, et al. Review of recent data on the metabolism, biological effects, and toxicity of resveratrol in humans. Molecular Nutrition and Food Research. 2013. In press. Accessed Sept. 5, 2013
- Anderson CA (expert opinion). Mayo Clinic, Rochester, Minn. Sept. 23, 2013.