Metastatic castration-resistant prostate cancer care at Mayo Clinic

晚期前列腺癌的放射性药物疗法

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Dan Childs,医学博士,肿瘤科医生: 长期以来,我们都认为晚期前列腺癌是无法治愈的。但现在我们接诊了一些转移性前列腺癌患者。我们对 PET 扫描显示出来的所有患癌部位进行治疗。最终,这些患者遵医嘱停用所有激素治疗后,在很长一段时间内,我们都没有观察到癌细胞生长的迹象。这让我对治愈晚期前列腺癌男性患者充满希望。

Jacob Orme,医学博士,哲学博士,肿瘤科医生: 晚期前列腺癌意味着癌症已经转移到其他部位,虽然原本起源于前列腺。可能转移到了骨骼,这是个很常见的转移部位,但也可能转移到肺部、肝脏或身体其他部位。但如果癌症已转移到其他部位,我们就必须采取一些能够从头到脚全面治疗的方法。因此,对于晚期前列腺癌,我们不再使用手术、放疗、冷冻消融等局部治疗,而是转向能在全身起作用的治疗。

Childs 医生: 幸运的是,我们目前有各种能够延长前列腺癌患者生命的疗法,远远超过以往任何时期。我们可以采用已经问世多年的化疗。也可以采用有助于缩小癌灶或减缓癌症生长的激素治疗。还可以采用一种被称为放射性药物的新型疗法。该疗法是过去十年间一项非常重要的创新。

Orme 医生: 现在的镥 PSMA 疗法发挥功能时,就像一个分子魔术贴,可以附着在癌细胞表面的 PSA 和放射性镥上。所以把它注射到血液中,它会分布到全身,然后附着在那些癌细胞的表面,并将辐射精准地递送到那些癌细胞。这个过程很棒,我们已经看到了一些非常好的效果。

如果我们采用这些先进的扫描技术,我们进行分子扫描,就可以看到癌症的确切位置,这对于我们肿瘤内科医生大有帮助,因为我们想知道肿瘤的扩散范围,这能帮我们找到治疗方法。

Childs 医生: 我们还能够在治疗后的第二天扫描成像,了解药物是否到达预期部位。

Geoffrey Johnson,医学博士,哲学博士,核医学专科医生,放射科医生: 为什么晚期前列腺癌患者倾向于接受这种诊疗一体化或放射性药物疗法? 最主要的原因是副作用小。因为我们能够设计药物,并且能够精确查看它们的去向,因此我们知道,这些药对其他部位没有产生辐射或是只有微乎其微的辐射。因此,患者在高尔夫球场上对球友这样说:我接受这种疗法后感觉比之前好多了,而我们的数据也印证了这一点。

我们能够发现癌症。我们能够在整个治疗过程中追踪肿瘤,从而真正指导治疗,几乎没有其他人能够这样做。甚至可以说,如果某种疗法对某些肿瘤无效,但对其他肿瘤有效,我们能够通过影像学检查观察到,然后可以引入其他疗法,比如外照射疗法,来治疗对先前疗法没有反应的肿瘤。对于医生、护士或者任何帮助护理这些患者的人来说,这都极具意义。

妙佑医疗国际的三大院区均已获得综合放射性药物疗法卓越中心的认证,这让我们引以为荣。那么,我们是以团队合作的形式提供服务,团队中包括泌尿科医生、放射肿瘤科医生、肿瘤内科医生、核医学医生,以及满足任何特定患者需求的其他医生。我认为这是妙佑医疗的一大特色,即我们的团队协作方式。

Childs 医生: 无论进行何种抗癌治疗,包括放射性药物疗法,我们都需要确保基础设施布置到位。我们需要确保拥有一支训练有素的医生、护士和技师团队。妙佑医疗国际早在这一疗法获批数月甚至数年前就已做足准备,一旦该疗法可用于治疗前列腺癌患者,我们就能立即投入使用,为患者提供支持。

Johnson 医生: 我想说的是,如果您前来妙佑医疗国际就诊,我们将致力于为您提供团队式诊疗服务。我们齐心协力,将您的最大利益放在首位。

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Mayo Clinic doctors provide expert care for people with metastatic castration-resistant prostate cancer (mCRPC).

Your Mayo Clinic care team

People with advanced prostate cancer receive care from doctors at Mayo Clinic Comprehensive Cancer Center. Mayo Clinic Comprehensive Cancer Center is the only National Cancer Institute-designated comprehensive cancer center with three locations in Arizona, Florida and Minnesota.

At Mayo Clinic, doctors and specialists work in multidisciplinary teams to address all of your needs and explore all of your options. Benefits of the team approach include:

Advanced diagnosis and treatment

Mayo Clinic specialists have access to the latest diagnosis and treatment innovations to provide you with an accurate diagnosis and effective treatment plan. This includes:

  • Detecting cancer recurrence sooner. Mayo Clinic was the first medical center to receive U.S. Food and Drug Administration approval to prepare and administer the choline C-11 PET scan, which helped doctors find prostate cancer recurrence sooner than other imaging available at the time. This innovation in prostate cancer imaging continues, as Mayo Clinic offers the latest tests, such as the PSMA PET scan.
  • A full range of treatments to consider. Mayo Clinic doctors will work with you to review all of your treatment options and choose the treatment that best suits your needs and goals. The range of treatments offered includes external beam radiation therapy, stereotactic body radiotherapy (SBRT), proton therapy, hormone therapy, targeted therapy, immunotherapy and radiopharmaceutical treatments.
  • Access to the latest in clinical trials. Mayo Clinic doctors participate in clinical trials studying the latest treatments and new ways to use existing treatments. Taking part in a clinical trial may give you access to new medicines for metastatic castration-resistant prostate cancer. Talk with your healthcare team about which trials might be a good fit for you.

专长与排名

Mayo Clinic doctors are widely respected for their experience and expertise in caring for people with prostate cancer recurrence. When you seek care at Mayo Clinic, you can expect:

  • Personalized care. Mayo Clinic urologists, medical oncologists, radiation oncologists, nuclear medicine specialists, pathologists and radiologists work together to ensure all of your needs are addressed when creating your customized treatment plan.
  • Experience you can trust. Each year, more than 23,000 people with prostate cancer receive care at Mayo Clinic. This experience means your care team is prepared with knowledge and resources to provide you with exactly the care you need.
  • Center of excellence for radiopharmaceutical treatments. The Society of Nuclear Medicine and Molecular Imaging has designated Mayo Clinic as a Comprehensive Radiopharmaceutical Therapy Center of Excellence. This honor extends to the Mayo Clinic campuses in Arizona, Florida and Minnesota.
  • Nationally recognized expertise. Mayo Clinic Comprehensive Cancer Center meets the strict standards for a National Cancer Institute-designated comprehensive cancer center. These standards recognize scientific excellence and a multispecialty approach focused on cancer prevention, diagnosis and treatment. Mayo Clinic Comprehensive Cancer Center is the only National Cancer Institute-designated comprehensive cancer center with three locations in Arizona, Florida and Minnesota.

在《美国新闻与世界报道》最佳医院评选中,妙佑医疗国际明尼苏达州罗切斯特院区、妙佑医疗国际佛罗里达州杰克逊维尔院区和妙佑医疗国际亚利桑那州凤凰城/斯科茨代尔院区均在癌症领域名列前茅。妙佑医疗国际明尼苏达州罗切斯特院区被评为明尼苏达州最佳医院,妙佑医疗国际亚利桑那州凤凰城/斯科茨代尔院区被评为亚利桑那州最佳医院。

Dec. 24, 2025

Metastatic castration-resistant prostate cancer (mCRPC)