How you prepare

To prepare for your prostate biopsy, your urologist may have you:

  • Provide a urine sample to analyze for a urinary tract infection. If you have a urinary tract infection, your prostate biopsy will likely be postponed while you take antibiotics to clear the infection.
  • Stop taking medication that can increase the risk of bleeding — such as warfarin (Coumadin), aspirin, ibuprofen (Advil, Motrin IB, others), and certain herbal supplements — for several days before the procedure.
  • Do a cleansing enema at home before your biopsy appointment.
  • Take antibiotics 30 to 60 minutes before your prostate biopsy to help prevent infection from the procedure.
Aug. 11, 2017
  1. Wein AJ, et al., eds. Prostate biopsy: Techniques and imaging. In: Campbell-Walsh Urology. 11th ed. Philadelphia, Pa.: Elsevier; 2016. Accessed Jan. 7, 2016.
  2. Benway BM, et al. Prostate biopsy. Accessed Jan. 7, 2016.
  3. AskMayoExpert. Prostate biopsy. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2015.
  4. Bjurlin MA, et al. Optimization of prostate biopsy: Review of technique and complications. Urologic Clinics of North America. 2014;41:299.
  5. How is prostate cancer diagnosed? American Cancer Society. Accessed Jan. 7, 2016.
  6. Ferri FF. Prostate cancer. In: Ferri's Clinical Advisor 2016. Philadelphia, Pa.: Mosby Elsevier; 2016. Accessed Jan. 6, 2016.
  7. Yang XJ. Interpretation of prostate biopsy. Accessed Jan. 7, 2016.