Facial fillers for wrinkles

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Facial fillers for wrinkles care at Mayo Clinic

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AboutCare at Mayo Clinic
July 15, 2025
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  1. AskMayoExpert. Soft tissue fillers and other injectables. Mayo Clinic; 2020.
  2. Kelly AP, et al., eds. Postinflammatory hyperpigmentation/periorbital hyperpigmentation. In: Taylor and Kelly's Dermatology for Skin of Color. 2nd ed. McGraw Hill; 2016. https://accessmedicine.mhmedical.com. Accessed Dec. 13, 2023.
  3. Medical review (expert opinion). Mayo Clinic. May 3, 2023.
  4. Dermal filler do's and don'ts for wrinkles, lips and more. U.S. Food and Drug Administration. https://www.fda.gov/consumers/consumer-updates/dermal-filler-dos-and-donts-wrinkles-lips-and-more. Accessed Sept. 20, 2023.
  5. Carruthers J, et al., eds. Introduction to temporary fillers: Pros and cons. In: Procedures in Cosmetic Dermatology: Soft Tissue Augmentation. 5th ed. Elsevier; 2024. https://www.clinicalkey.com. Accessed Sept. 20, 2023.
  6. Desmond Markey J, et al. Advances in nonsurgical periocular rejuvenation. Facial Plastic Surgery Clinics of North America. 2022; doi:org/10.1016/j.fsc.2022.03.006.
  7. Health Education & Content Services. Smoothing wrinkles and scars by soft tissue augmentation. Mayo Clinic; 2017.
  8. Carruthers J, et al., eds. Complications of temporary fillers. In: Procedures in Cosmetic Dermatology: Soft Tissue Augmentation. 5th ed. Elsevier; 2024. https://www.clinicalkey.com. Accessed Dec. 13, 2023.
  9. Carruthers J, et al., eds. Bellafill. In: Procedures in Cosmetic Dermatology: Soft Tissue Augmentation. 5th ed. Elsevier; 2024. https://www.clinicalkey.com. Accessed Dec. 13, 2023.
  10. Carruthers J, et al., eds. Poly-L-lactic acid. In Procedures in Cosmetic Dermatology: Soft Tissue Augmentation. 5th ed. Elsevier; 2024. https://www.clinicalkey.com. Accessed Dec. 13, 2023.
  11. Fillers: FAQs. American Academy of Dermatology. https://www.aad.org/public/cosmetic/wrinkles/fillers-faqs. Accessed Dec. 13, 2023.
  12. Chesnut, C. Restoration of visual loss with retrobulbar hyaluronidase injection after hyaluronic acid filler. Dermatologic Surgery. 2018; doi:10.1097/DSS.0000000000001237.
  13. Carruthers J, et al. Injectable soft tissue fillers: Overview of clinical use. https://www.uptodate.com/contents/search. Accessed Dec. 19, 2023.
  14. Carruthers J, et al. Injectable soft tissue fillers: Permanent agents. https://www.uptodate.com/contents/search. Accessed Dec. 19, 2023.

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Facial fillers for wrinkles