Before Using

Drug information provided by: IBM Micromedex

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Appropriate studies have not been performed on the relationship of age to the effects of rifapentine to treat active tuberculosis in children younger than 12 years of age, nor to treat inactive tuberculosis in children younger than 2 years of age. Safety and efficacy have not been established in these age groups.


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of rifapentine in the elderly.


Information about this rifapentine-oral-route
Pregnancy Category Explanation
All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.


Studies suggest that this medication may alter milk production or composition. If an alternative to this medication is not prescribed, you should monitor the infant for side effects and adequate milk intake.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Artemether
  • Delamanid
  • Doravirine
  • Lurasidone
  • Ranolazine
  • Rilpivirine

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Alfentanil
  • Amprenavir
  • Apremilast
  • Bedaquiline
  • Benzhydrocodone
  • Bictegravir
  • Buprenorphine
  • Ceritinib
  • Cholera Vaccine, Live
  • Clarithromycin
  • Cobicistat
  • Codeine
  • Darunavir
  • Desogestrel
  • Dienogest
  • Dihydrocodeine
  • Doxorubicin
  • Doxorubicin Hydrochloride Liposome
  • Dronedarone
  • Drospirenone
  • Elvitegravir
  • Enzalutamide
  • Erlotinib
  • Estradiol Cypionate
  • Estradiol Valerate
  • Ethinyl Estradiol
  • Ethynodiol Diacetate
  • Etonogestrel
  • Etravirine
  • Exemestane
  • Fentanyl
  • Fosamprenavir
  • Hydrocodone
  • Indinavir
  • Irinotecan
  • Irinotecan Liposome
  • Ketoconazole
  • Lapatinib
  • Ledipasvir
  • Levonorgestrel
  • Linagliptin
  • Lopinavir
  • Lumateperone
  • Medroxyprogesterone Acetate
  • Meperidine
  • Mestranol
  • Methadone
  • Mifepristone
  • Naloxegol
  • Nelfinavir
  • Nevirapine
  • Nifedipine
  • Nilotinib
  • Nimodipine
  • Norelgestromin
  • Norethindrone
  • Norgestimate
  • Norgestrel
  • Oxycodone
  • Panobinostat
  • Pazopanib
  • Pentazocine
  • Piperaquine
  • Ponatinib
  • Regorafenib
  • Ritonavir
  • Saquinavir
  • Simeprevir
  • Sofosbuvir
  • Sorafenib
  • Sufentanil
  • Sunitinib
  • Tacrolimus
  • Tasimelteon
  • Tenofovir Alafenamide
  • Ticagrelor
  • Tipranavir
  • Tolvaptan
  • Tramadol
  • Ubrogepant
  • Ulipristal
  • Vandetanib
  • Velpatasvir
  • Vilazodone
  • Vincristine
  • Vincristine Sulfate Liposome
  • Vortioxetine
  • Voxilaprevir

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acenocoumarol
  • Acetyldigoxin
  • Alprazolam
  • Amiodarone
  • Amitriptyline
  • Amlodipine
  • Aranidipine
  • Bepridil Hydrochloride
  • Betamethasone
  • Bisoprolol
  • Carbamazepine
  • Carteolol
  • Carvedilol
  • Chloramphenicol
  • Chlorpropamide
  • Cilnidipine
  • Ciprofloxacin
  • Clevidipine
  • Clofibrate
  • Cyclosporine
  • Dapsone
  • Delavirdine
  • Deslanoside
  • Dexamethasone
  • Diazepam
  • Dicumarol
  • Digitoxin
  • Digoxin
  • Diltiazem
  • Disopyramide
  • Doxycycline
  • Felodipine
  • Fluconazole
  • Fludrocortisone
  • Fosphenytoin
  • Gallopamil
  • Glyburide
  • Haloperidol
  • Hydrocortisone
  • Isradipine
  • Lorcainide
  • Manidipine
  • Metildigoxin
  • Metoprolol
  • Mexiletine
  • Nicardipine
  • Nisoldipine
  • Nitrazepam
  • Nitrendipine
  • Nortriptyline
  • Ospemifene
  • Phenprocoumon
  • Phenytoin
  • Prednisone
  • Propafenone
  • Propranolol
  • Quinidine
  • Quinine
  • Repaglinide
  • Sildenafil
  • Talinolol
  • Temazepam
  • Tertatolol
  • Theophylline
  • Tocainide
  • Tolbutamide
  • Triazolam
  • Valproic Acid
  • Verapamil
  • Warfarin
  • Zidovudine

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Alcohol abuse, or history of—May increase risk for more serious side effects.
  • Elevated liver enzymes or
  • Liver disease—Use with caution. May make these conditions worse.
  • Porphyria—Avoid use of rifapentine in patients with this condition.