Proper Use

Drug information provided by: Merative, Micromedex®

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance for side effects.

This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.

Take this medicine with food.

Swallow the tablet whole. If you cannot swallow it whole, you may crush it and add it to a small amount of semi-solid food. Take all of it right away and do not store it for later use.

To help clear up your infection completely, it is very important that you keep using this medicine for the full time of treatment, even if you begin to feel better after a few weeks. If you have TB, you might have to take rifapentine for several months. It is important that you not miss any doses.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (tablets):
    • For the treatment of active tuberculosis:
      • Adults and children 12 years of age and older—600 milligrams (mg) 2 times a week with an interval of not less than 3 days (72 hours) between doses. Then, 600 mg once a week taken for 4 months with isoniazid or other medicines.
      • Children younger than 12 years of age—Use and dose must be determined by your doctor.
    • For the treatment of latent tuberculosis:
      • Adults and children 12 years of age and older—Dose is based on body weight and must be determined by your doctor. The dose is usually up to 900 milligrams (mg) once a week taken with isoniazid for 12 weeks.
      • Children 2 to 11 years of age—Dose is based on body weight and must be determined by your doctor. The dose is usually taken with isoniazid for 12 weeks.
        • Weighing more than 50 kilograms (kg)—900 mg (6 tablets) once a week.
        • Weighing 32.1 to 50 kg—750 mg (5 tablets) once a week.
        • Weighing 25.1 to 32 kg—600 mg (4 tablets) once a week.
        • Weighing 14.1 to 25 kg—450 mg (3 tablets) once a week.
        • Weighing 10 to 14 kg—300 mg (2 tablets) once a week.
      • Children younger than 2 years of age—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Portions of this document last updated: May 01, 2024

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