Your doctor will take a medical history to document recurrent infections and do a physical exam. He or she will order blood tests and possibly recommend genetic testing to confirm the diagnosis.


There's no cure for XLA. The goal of treatment is to boost the immune system, preventing infections and aggressively treating infections that occur.


Medications to treat XLA include:

  • Gammaglobulin. This is a type of protein found in blood that contains antibodies against infections. It's given by infusion into a vein every two to four weeks or by weekly injection.

    Reactions to gammaglobulin can include headache, chills, backache and nausea. Reactions are more likely to occur during a viral infection.

  • Antibiotics. Some people with XLA receive continuous antibiotics to prevent infections. Others take antibiotics for bacterial infections longer than people without XLA do.

Your doctor will likely recommend that you have follow-up visits every six to 12 months to screen for complications of XLA. You'll also likely be advised to not get live vaccines, such as live polio, measles-mumps-rubella or chickenpox vaccines.

Clinical trials

Explore Mayo Clinic studies testing new treatments, interventions and tests as a means to prevent, detect, treat or manage this condition.

X-linked agammaglobulinemia care at Mayo Clinic

Sept. 09, 2022

Living with x-linked agammaglobulinemia?

Connect with others like you for support and answers to your questions in the Blood Cancers & Disorders support group on Mayo Clinic Connect, a patient community.

Blood Cancers & Disorders Discussions

High Platelets

6 Replies Tue, Nov 15, 2022

MGUS monitoring: What tests do you have done regularly?

11 Replies Mon, Nov 07, 2022

See more discussions
  1. X-linked agammaglobulinemia. Genetic and Rare Diseases Information Center. https://rarediseases.info.nih.gov/diseases/1033/x-linked-agammaglobulinemia. Accessed Nov. 24, 2019.
  2. Hernandez-Trujillo VP. Agammaglobulinemia. https://www.uptodate.com/contents/search. Accessed Nov. 24, 2019.
  3. X-linked agammaglobulinemia. Merck Manual Professional Version. https://www.merckmanuals.com/professional/immunology-allergic-disorders/immunodeficiency-disorders/x-linked-agammaglobulinemia. Accessed Nov. 24, 2019.
  4. AskMayoExpert. Common variable immunodeficiency. Mayo Clinic; 2018.
  5. X-linked agammaglobulinemia. Genetics Home Reference. https://ghr.nlm.nih.gov/condition/x-linked-agammaglobulinemia#:~:targetText=X%2Dlinked%20agammaglobulinemia%20(XLA),protect%20the%20body%20against%20infection. Accessed Nov. 24, 2019.
  6. Agammaglobulinemia: X-linked and autosomal recessive. Immune Deficiency Foundation. https://primaryimmune.org/about-primary-immunodeficiencies/specific-disease-types/agammaglobulinemia-x-linked-autosomal-recessive/?gclid=EAIaIQobChMIuPyMwJ2D5gIVyEXVCh2P3AYZEAAYASAAEgJY_fD_BwE. Accessed Nov. 24, 2019.
  7. Brown AY. Allscripts EPSi. Mayo Clinic. Nov.14, 2019.


Products & Services