Overview

Pulmonary valve disease is a condition in which the lung (pulmonary) valve — located between your heart's lower right chamber (right ventricle) and the artery that delivers blood to the lungs (pulmonary artery) — doesn't work properly. The condition can interrupt blood flow from your heart to your lungs.

The pulmonary valve normally acts like a one-way door from your heart's right ventricle to the lungs. Blood flows from the right ventricle through the pulmonary valve to the pulmonary artery and then into the lungs, where it picks up oxygen to deliver to your body.

Types of pulmonary valve disease include:

  • Pulmonary valve stenosis. Narrowing of the pulmonary valve reduces the blood flow from the heart to the pulmonary artery and lungs.
  • Pulmonary valve regurgitation. The flaps (leaflets) of the pulmonary valve don't close tightly, causing blood to leak backward into the right ventricle.
  • Pulmonary atresia. This condition is present at birth (congenital). The pulmonary valve isn't formed. Instead, a solid sheet of tissue blocks blood flow from the right side of the heart, so blood can't go to the lungs to pick up oxygen.

Many types of pulmonary valve disease are due to heart conditions present at birth (congenital heart defects). Treatment depends on the type and severity of pulmonary valve disease.

Clinical trials

Explore Mayo Clinic studies testing new treatments, interventions and tests as a means to prevent, detect, treat or manage this condition.

Pulmonary valve disease care at Mayo Clinic

Aug. 24, 2021
  1. Heart valve disease. National Heart, Lung, and Blood Institute. http://www.nhlbi.nih.gov/health/health-topics/topics/hvd. Accessed May 12, 2021.
  2. Pulmonary valve stenosis. American Heart Association. https://www.heart.org/en/health-topics/congenital-heart-defects/about-congenital-heart-defects/pulmonary-valve-stenosis#.Vjp2ttiFPmI. Accessed May 12, 2021.
  3. Stout K. Clinical manifestations and diagnosis of pulmonic stenosis in adults. https://www.uptodate.com/contents/search. Accessed May 12, 2021.
  4. Single ventricle defects. American Heart Association. https://www.heart.org/en/health-topics/congenital-heart-defects/about-congenital-heart-defects/single-ventricle-defects#.Vjp3INiFPmI. Accessed May 12, 2021.
  5. Brown AY. Allscripts EPSi. Mayo Clinic. May 18, 2021.
  6. Cabalka AK, et al. Transcatheter pulmonary valve replacement using the melody valve for treatment of dysfunctional surgical bioprostheses: A multicenter study. The Journal of Thoracic and Cardiovascular Surgery. 2018; doi:10.1016/j.jtcvs.2017.10.143.
  7. Stout K. Natural history and treatment of pulmonic stenosis in adults. https://www.uptodate.com/contents/search. Accessed May 12, 2021.