Do men with a higher prostate-specific antigen (PSA) level have a worse prostate cancer prognosis?
Answer From Patricio C. Gargollo, M.D.
Yes. In most cases, a higher PSA level indicates a poorer prostate cancer prognosis.
PSA is a protein made by prostate tissue. Men with prostate cancer often have elevated PSA levels because the cancer cells make excessive amounts of this protein.
At the time of initial diagnosis of prostate cancer, the PSA level helps determine how likely it is that the cancer has spread (metastasized). It also helps determine how likely the cancer will be cured with treatment such as radiation or surgery. Your doctor also considers other factors, such as your prostate cancer stage, the grade of your cancer and your Gleason score in figuring your prognosis.
If you have been diagnosed with prostate cancer and are concerned about your prognosis, discuss your situation with your doctor.
Patricio C. Gargollo, M.D.
Aug. 06, 2020
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See more Expert Answers
- Wein AJ, et al., eds. Prostate cancer tumor markers. In: Campbell-Walsh Urology. 11th ed. Philadelphia, Pa.: Elsevier; 2016. https://www.clinicalkey.com. Accessed July 6, 2017.
- Prostate cancer. Fort Washington, Pa.: National Comprehensive Cancer Network. http://www.nccn.org/professionals/physician_gls/f_guidelines.asp. Accessed March 31, 2017.
- Hoffman RM. Screening for prostate cancer. https://www.uptodate.com/contents/search. Accessed July 6, 2017.