Primary sclerosing cholangitis care at Mayo Clinic

Your Mayo Clinic care team

Effective treatment of primary sclerosing cholangitis requires coordinated care by several specialties. Specialists in gastroenterology and hepatology, pathologists, oncologists, pediatric specialists, endoscopy specialists and surgeons work as a team to provide comprehensive care for adults and children with primary sclerosing cholangitis.

If a transplant is necessary, these specialists also work with transplant surgeons and other experts to provide a seamless patient experience in Mayo Clinic's Liver Transplant Program. The Hepatobiliary Clinic coordinates medical care with research.

Pediatric expertise

Specialists in the Pediatric Liver Clinic at Mayo Clinic's campus in Minnesota are experienced in accurately diagnosing children who have liver diseases.

An efficient system

A detailed itinerary for appointments, tests and procedures lets you make the most of your time at the clinic. Mayo staff runs all tests and labs at Mayo Clinic, which means tests taken in the morning can be reviewed the same afternoon. This collaborative approach means doctors can often evaluate you and develop a treatment plan within two or three days.

Individualized care

Your Mayo Clinic team will tailor a treatment plan to fit your or your child's needs. Your Mayo Clinic treatment team will educate you and your family about primary sclerosing cholangitis. Your doctors will also work closely with your primary doctor in providing your follow-up care.

Expertise and rankings


Mayo Clinic is a leading treatment center for people with primary sclerosing cholangitis, caring for more than 500 people annually with this uncommon digestive condition.

Pioneers in research

Many Mayo Clinic doctors are involved in clinical trials of new medications for primary sclerosing cholangitis. Researchers at Mayo Clinic are also studying the DNA of people with primary sclerosing cholangitis in hopes of identifying genes that increase the risk of the disease and predict its course.

Liver transplant

Mayo Clinic transplant specialists have performed many transplants in people who have primary sclerosing cholangitis. People with primary sclerosing cholangitis who have liver transplants generally have high survival rates — 80% to 85% after five years on average. Recipients of liver transplants at Mayo Clinic have above-average survival rates.

Mayo Clinic is also one of the few medical centers in the country to offer liver transplants as a treatment option for bile duct cancer, which develops at much higher rates among people with primary sclerosing cholangitis than in the general population.

Nationally recognized expertise

Mayo Clinic in Rochester, Minnesota, ranks No. 1 for digestive disorders in the U.S. News & World Report Best Hospitals rankings. Mayo Clinic in Phoenix/Scottsdale, Arizona, and Mayo Clinic in Jacksonville, Florida, are ranked among the Best Hospitals for digestive disorders by U.S. News & World Report. Mayo Clinic Children's Center in Rochester is ranked the No. 1 hospital in Minnesota, and the five-state region of Iowa, Minnesota, North Dakota, South Dakota and Wisconsin, according to U.S. News & World Report's 2023–2024 "Best Children's Hospitals" rankings.

Learn more about the Liver Transplant Program's expertise and rankings.

Locations, travel and lodging

Mayo Clinic has major campuses in Phoenix and Scottsdale, Arizona; Jacksonville, Florida; and Rochester, Minnesota. The Mayo Clinic Health System has dozens of locations in several states.

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Costs and insurance

Mayo Clinic works with hundreds of insurance companies and is an in-network provider for millions of people.

In most cases, Mayo Clinic doesn't require a physician referral. Some insurers require referrals or may have additional requirements for certain medical care. All appointments are prioritized on the basis of medical need.

Learn more about appointments at Mayo Clinic.

Please contact your insurance company to verify medical coverage and to obtain any needed authorization prior to your visit. Often, your insurer's customer service number is printed on the back of your insurance card.

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June 21, 2023


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