Primary sclerosing cholangitis (PSC)

Oct. 15, 2025

Primary sclerosing cholangitis care at Mayo Clinic

Your Mayo Clinic care team

Effective treatment of primary sclerosing cholangitis (PSC) requires coordinated care by several specialties. Specialists in gastroenterology and hepatology, pathologists, oncologists, pediatric specialists, endoscopy specialists, and surgeons work as a team to provide care for adults and children with PSC.

If a transplant is necessary, these specialists also work with transplant surgeons and other experts to provide a seamless patient experience in Mayo Clinic's Liver Transplant Program. The Hepatobiliary Clinic coordinates medical care with research.

Pediatric expertise

Specialists in the Pediatric Liver Clinic at Mayo Clinic's campus in Minnesota are experienced in accurately diagnosing children who have liver diseases.

An efficient system

A detailed itinerary for appointments, tests and procedures lets you make the most of your time at the clinic. Mayo staff runs all tests and labs at Mayo Clinic, which means tests taken in the morning can be reviewed the same afternoon. This collaborative approach means your team can often evaluate you and develop a treatment plan within two or three days.

Individualized care

Your Mayo Clinic team tailors a treatment plan to fit your or your child's needs. Your Mayo Clinic treatment team will educate you and your family about PSC. Your team also will work closely with your primary healthcare professional in providing your follow-up care.

Expertise and rankings

Experience

Mayo Clinic is a leading treatment center for people with PSC, caring for more than 850 people annually with this uncommon digestive condition.

Liver transplant

Mayo Clinic transplant specialists have performed many transplants in people who have PSC. People with PSC who have liver transplants generally have high survival rates — about 80% after five years on average. Recipients of liver transplants at Mayo Clinic have above-average survival rates.

Mayo Clinic also is one of the few medical centers in the country to offer liver transplants as a treatment option for bile duct cancer, which develops at much higher rates among people with PSC than in the general population.

Learn more about the Liver Transplant Program's expertise and rankings.

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