Pancreatic cancer FAQs
Get answers to the most frequently asked questions about pancreatic cancer from Mayo Clinic surgical oncologist Chee-Chee Stucky, M.D.
Hi. I'm Dr. Chee-Chee Stucky, a surgical oncologist at Mayo Clinic, and I'm here to answer some of the important questions you might have about pancreatic cancer.
Is pancreatic cancer preventable?
Technically, no. There are some risk factors associated with pancreatic cancer, like smoking and obesity. Those are both modifiable risk factors. So the healthier you are, the less risk you might have of pancreatic cancer. But ultimately if you have a pancreas, there's always a risk of developing pancreatic cancer.
Do all pancreatic cysts become cancerous?
The short answer is no. The vast majority of pancreatic cysts will not become cancerous. There are a few, but I would recommend asking your doctor about those.
How are breast cancer and pancreatic cancer connected?
The connection between breast cancer and pancreatic cancer is a genetic mutation called BRCA. So anybody who might have a newly diagnosed pancreatic cancer, but a family history of breast cancer, should definitely undergo genetic testing in order to see if there is a mutation present. If so, the rest of the family needs to undergo screening and possibly genetic testing with the hopes of potentially identifying cancer at an earlier stage.
What is the Whipple procedure?
The Whipple procedure is one of the most common procedures we do for pancreatic cancer, Specifically when located in the head or uncinate process of the pancreas. Because of where that tumor is located, we also have to remove everything that's connected to the pancreas, specifically the duodenum and the bile duct, as well as the surrounding lymph nodes. Once it's all removed, then we need to put everything back together, which includes the biliary tract, the pancreatic duct, and the GI tract.
Can you live without a pancreas?
You can definitely live without a pancreas. You will have diabetes. But fortunately with our new technologies, insulin pumps are much improved. And therefore, patients still have a good quality of life.
How can I be the best partner to my medical team?
You can be the best partner to your medical team by staying healthy, staying informed, ask a lot of questions and bring somebody with you to your appointments so they can be an additional set of eyes and ears. Never hesitate to ask your medical team any questions or concerns you have. Being informed makes all the difference. Thanks for your time and we wish you well.
During an endoscopic ultrasound of the pancreas, your doctor inserts a thin, flexible tube (endoscope) down your throat and into your stomach. An ultrasound device at the end of the tube emits sound waves that generate images of your digestive tract and nearby organs and tissues.
If your doctor suspects pancreatic cancer, he or she may have you undergo one or more of the following tests:
- Imaging tests that create pictures of your internal organs. These tests help your doctors visualize your internal organs, including the pancreas. Techniques used to diagnose pancreatic cancer include ultrasound, computerized tomography (CT) scans, magnetic resonance imaging (MRI) and, sometimes, positron emission tomography (PET) scans.
- Using a scope to create ultrasound pictures of your pancreas. An endoscopic ultrasound (EUS) uses an ultrasound device to make images of your pancreas from inside your abdomen. The device is passed through a thin, flexible tube (endoscope) down your esophagus and into your stomach in order to obtain the images.
- Removing a tissue sample for testing (biopsy). A biopsy is a procedure to remove a small sample of tissue for examination under a microscope. Most often the tissue is collected during EUS by passing special tools through the endoscope. Less often, a sample of tissue is collected from the pancreas by inserting a needle through your skin and into your pancreas (fine-needle aspiration).
- Blood test. Your doctor may test your blood for specific proteins (tumor markers) shed by pancreatic cancer cells. One tumor marker test used in pancreatic cancer is called CA19-9. It may be helpful in understanding how the cancer responds to treatment. But the test isn't always reliable because some people with pancreatic cancer don't have elevated CA19-9 levels, making the test less helpful.
If your doctor confirms a diagnosis of pancreatic cancer, he or she tries to determine the extent (stage) of the cancer. Using information from staging tests, your doctor assigns your pancreatic cancer a stage, which helps determine what treatments are most likely to benefit you.
The stages of pancreatic cancer are indicated by Roman numerals ranging from 0 to IV. The lowest stages indicate that the cancer is confined to the pancreas. By stage IV, the cancer has spread to other parts of the body.
The cancer staging system continues to evolve and is becoming more complex as doctors improve cancer diagnosis and treatment.
Don't hesitate to ask your doctor about his or her experience with diagnosing pancreatic cancer. If you have any doubts, get a second opinion.
Treatment for pancreatic cancer depends on the stage and location of the cancer as well as on your overall health and personal preferences. For most people, the first goal of pancreatic cancer treatment is to eliminate the cancer, when possible. When that isn't an option, the focus may be on improving your quality of life and limiting the cancer from growing or causing more harm.
Treatment may include surgery, radiation, chemotherapy or a combination of these. When pancreatic cancer is advanced and these treatments aren't likely to offer a benefit, your doctor will focus on symptom relief (palliative care) to keep you as comfortable as possible for as long as possible.
The Whipple procedure (pancreaticoduodenectomy) is an operation to remove the head of the pancreas, the first part of the small intestine (duodenum), the gallbladder and the bile duct. The remaining organs are reattached to allow you to digest food normally after surgery.
Advanced pancreatic cancer surgeries offer hope.
Click here for an infographic to learn more
Operations used in people with pancreatic cancer include:
Surgery for tumors in the pancreatic head. If your cancer is located in the head of the pancreas, you may consider an operation called a Whipple procedure (pancreaticoduodenectomy).
The Whipple procedure is a technically difficult operation to remove the head of the pancreas, the first part of the small intestine (duodenum), the gallbladder, part of the bile duct and nearby lymph nodes. In some situations, part of the stomach and colon may be removed as well. Your surgeon reconnects the remaining parts of your pancreas, stomach and intestines to allow you to digest food.
- Surgery for tumors in the pancreatic body and tail. Surgery to remove the left side (body and tail) of the pancreas is called distal pancreatectomy. Your surgeon may also need to remove your spleen.
- Surgery to remove the entire pancreas. In some people, the entire pancreas may need to be removed. This is called total pancreatectomy. You can live relatively normally without a pancreas but do need lifelong insulin and enzyme replacement.
- Surgery for tumors affecting nearby blood vessels. Many people with advanced pancreatic cancer aren't considered eligible for the Whipple procedure or other pancreatic surgeries if their tumors involve nearby blood vessels. At highly specialized and experienced medical centers, surgeons may offer pancreatic surgery operations that include removing and reconstructing affected blood vessels.
Each of these surgeries carries the risk of bleeding and infection. After surgery some people experience nausea and vomiting if the stomach has difficulty emptying (delayed gastric emptying). Expect a long recovery after any of these procedures. You'll spend several days in the hospital and then recover for several weeks at home.
Extensive research shows pancreatic cancer surgery tends to cause fewer complications when done by highly experienced surgeons at centers that do many of these operations. Don't hesitate to ask about your surgeon's and hospital's experience with pancreatic cancer surgery. If you have any doubts, get a second opinion.
Chemotherapy uses drugs to help kill cancer cells. These drugs can be injected into a vein or taken orally. You may receive one chemotherapy drug or a combination of them.
Chemotherapy can also be combined with radiation therapy (chemoradiation). Chemoradiation is typically used to treat cancer that hasn't spread beyond the pancreas to other organs. At specialized medical centers, this combination may be used before surgery to help shrink the tumor. Sometimes it is used after surgery to reduce the risk that pancreatic cancer may recur.
In people with advanced pancreatic cancer and cancer that has spread to other parts of the body, chemotherapy may be used to control cancer growth, relieve symptoms and prolong survival.
Radiation therapy uses high-energy beams, such as those made from X-rays and protons, to destroy cancer cells. You may receive radiation treatments before or after cancer surgery, often in combination with chemotherapy. Or your doctor may recommend a combination of radiation and chemotherapy treatments when your cancer can't be treated surgically.
Radiation therapy usually comes from a machine that moves around you, directing radiation to specific points on your body (external beam radiation). In specialized medical centers, radiation therapy may be delivered during surgery (intraoperative radiation).
Traditional radiation therapy uses X-rays to treat cancer, but a newer form of radiation using protons is available at some medical centers. In certain situations, proton therapy can be used to treat pancreatic cancer and it may offer fewer side effects compared with standard radiation therapy.
Clinical trials are studies to test new treatments, such as systemic therapy, and new approaches to surgery or radiation therapy. If the treatment being studied proves to be safer and more effective than current treatments, it can become the new standard of care.
Clinical trials for pancreatic cancer might give you a chance to try new targeted therapy, chemotherapy drugs, immunotherapy treatments or vaccines.
Clinical trials can't guarantee a cure, and they might have serious or unexpected side effects. On the other hand, cancer clinical trials are closely monitored to ensure they're conducted as safely as possible. And they offer access to treatments that wouldn't otherwise be available to you.
Talk to your doctor about what clinical trials might be appropriate for you.
Supportive (palliative) care
Palliative care is specialized medical care that focuses on providing relief from pain and other symptoms of a serious illness. Palliative care is not the same as hospice care or end-of-life care. Palliative care is provided by teams of doctors, nurses, social workers and other specially trained professionals. These teams aim to improve the quality of life for people with cancer and their families.
Palliative care specialists work with you, your family and your other doctors to provide an extra layer of support that complements your ongoing medical care. It's often used while undergoing aggressive treatments, such as surgery, chemotherapy and radiation therapy.
When palliative care is used along with other appropriate treatments — even soon after the diagnosis — people with cancer may feel better and live longer.
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Some integrative and alternative medicine approaches may help with signs and symptoms you experience due to your cancer or cancer treatments.
Treatments to help you cope with distress
People with cancer frequently experience distress. Some research suggests distress is more common in people with pancreatic cancer than it is in people with other types of cancer.
If you're distressed, you may have difficulty sleeping and find yourself constantly thinking about your cancer. You may feel angry or sad.
Discuss your feelings with your doctor. Specialists can help you sort through your feelings and help you devise strategies for coping. In some cases, medications may help.
Integrative medicine and alternative therapies may also help you cope with distress. Examples include:
- Art therapy
- Massage therapy
- Music therapy
- Relaxation exercises
Talk with your doctor if you're interested in these treatment options.
Coping and support
Learning you have a life-threatening illness can be devastating. Some of the following suggestions may help:
Learn what you need to know about your cancer. Learn enough about your cancer to help you make decisions about your care. Ask your doctor about the details of your cancer and your treatment options. Ask about trusted sources of further information.
If you're doing your own research, good places to start include the National Cancer Institute and the Pancreatic Cancer Action Network.
- Assemble a support system. Ask your friends and family to form a support network for you. They may feel helpless and uncertain after your diagnosis. Helping you with simple tasks might give them comfort. And you might find relief in not having to worry about certain tasks. Think of things you want help with, such as meal preparation or getting to appointments.
- Find someone to talk with. Although friends and family can be your best allies, in some cases they have difficulty coping with the shock of your diagnosis. In these cases, talking with a counselor, medical social worker, or a pastoral or religious counselor can be helpful. Ask your doctor for a referral.
- Connect with other cancer survivors. You may find comfort in talking with other cancer survivors. Contact your local chapter of the American Cancer Society to find cancer support groups in your area. The Pancreatic Cancer Action Network can connect you with a pancreatic cancer survivor who can provide support by phone or email.
- Consider hospice. Hospice care provides comfort and support to terminally ill people and their loved ones. It allows family and friends — with the aid of nurses, social workers and trained volunteers — to care for and comfort a loved one at home or in a hospice residence. Hospice care also provides emotional, social and spiritual support for people who are ill and those closest to them.
Preparing for your appointment
Start by making an appointment with your doctor if you have any signs or symptoms that worry you. He or she may recommend tests and procedures to investigate your signs and symptoms. If your doctor suspects you have pancreatic cancer, he or she might refer you to:
- A doctor who diagnoses and treats digestive conditions (gastroenterologist)
- A doctor who treats cancer (oncologist)
- A doctor who uses radiation to treat cancer (radiation oncologist)
- A surgeon who specializes in operations involving the pancreas
What you can do
- Be aware of any pre-appointment restrictions, such as restricting your diet.
- List your symptoms, including any that seem unrelated to the reason you scheduled the appointment.
- List key personal information, including any recent changes or stressors.
- List all of your medications, vitamins and supplements, including doses.
- Ask a relative or friend to accompany you, to help you remember what the doctor says.
Questions to ask your doctor
- Do I have pancreatic cancer?
- What is the stage of my cancer?
- Will I need additional tests?
- Can my cancer be cured?
- What are my treatment options?
- Can any treatment help me live longer?
- What are the potential risks of each treatment?
- Is there one treatment you think is best for me?
- What advice would you give a friend or a family member in my situation?
- What is your experience with pancreatic cancer diagnosis and treatment? How many surgical procedures for this type of cancer are done each year at this medical center?
- I'm experiencing these signs and symptoms. What can be done to help me feel more comfortable?
- What clinical trials are available for pancreatic cancer? Am I eligible for any?
- Am I eligible for molecular profiling of my cancer?
- Do you have any brochures or other printed material that I can take with me? What websites do you recommend?
What to expect from your doctor
Your doctor is likely to ask you a number of questions, such as:
- When did you first begin experiencing symptoms?
- How severe are your symptoms? Are they occasional or continuous?
- Does anything improve or worsen your symptoms?
Nov. 30, 2022