Lupus is a disease that occurs when your body's immune system attacks your own tissues and organs (autoimmune disease). Inflammation caused by lupus can affect many different body systems — including your joints, skin, kidneys, blood cells, brain, heart and lungs.

Lupus can be difficult to diagnose because its signs and symptoms often mimic those of other ailments. The most distinctive sign of lupus — a facial rash that resembles the wings of a butterfly unfolding across both cheeks — occurs in many but not all cases of lupus.

Some people are born with a tendency toward developing lupus, which may be triggered by infections, certain drugs or even sunlight. While there's no cure for lupus, treatments can help control symptoms.

Oct. 21, 2022
  1. Ferri FF. Systemic lupus erythematosus. In: Ferri's Clinical Advisor 2021. Elsevier; 2021. https://www.clinicalkey.com. Accessed Nov. 2, 2020.
  2. Systemic lupus erythematosus (lupus). National Institute of Arthritis and Musculoskeletal and Skin Diseases. https://www.niams.nih.gov/health-topics/lupus. Accessed Nov. 2, 2020.
  3. Goldman L, et al., eds. Systemic lupus erythematosus. In: Goldman-Cecil Medicine. 26th ed. Elsevier; 2020. https://www.clinicalkey.com. Accessed Nov. 2, 2020.
  4. Wallace DJ, et al. Clinical manifestations and diagnosis of systemic lupus erythematosus in adults. https://www.uptodate.com/contents/search. Accessed Nov. 2, 2020.
  5. Wallace DJ. Overview of the management and prognosis of systemic lupus erythematosus in adults. https://www.uptodate.com/contents/search. Accessed Nov. 2, 2020.
  6. Dorner T, et al. Novel paradigms in systemic lupus erythematosus. Lancet. 2019; doi:10.1016/S0140-6736(19)30546-X.
  7. Calcium fact sheet for professionals. Office of Dietary Supplements. https://ods.od.nih.gov/factsheets/Calcium-HealthProfessional/. Accessed Nov. 5, 2020.
  8. Fangtham M, et al. Non-pharmacologic therapies for systemic lupus erythematosus. Lupus. 2019; doi:10.1177/0961203319841435.
  9. Sahu, P, et al. Pharmacological activities of dehydroepiandrosterone: A review. Steroids. 2020; doi:10.1016/j.steroids.2019.108507.
  10. Wierenga, KA, et al. Lupus, silica and dietary omega-3 fatty acid interventions. Toxicologic Pathology. 2019; doi:10.1177/0192623319878398.
  11. He Y, et al. Drug-induced lupus erythematosus: An update on drugs and mechanisms. Current Opinion in Rheumatology. 2018; doi:10.1097/BOR.0000000000000522.
  12. Yung S, et al. A review of advances in the understanding of lupus nephritis pathogenesis as a basis for emerging therapies. F1000Research. 2020; doi:10.12688/f1000research.22438.1.