Hilar cholangiocarcinoma

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Research

Researchers discuss a bile duct cancer project Bile duct cancer researchers

Doctors and scientists work together to develop new options for people with bile duct cancer.

Researchers at Mayo Clinic are studying new ways to diagnose and treat hilar cholangiocarcinoma. This research is conducted as part of the Division of Gastroenterology and Hepatology in coordination with Mayo Clinic Cancer Center.

Mayo Clinic Cancer Center receives funding from the National Cancer Institute (NCI) and is an NCI-designated comprehensive cancer center — recognition for an institution's scientific excellence and multidisciplinary resources focused on cancer prevention, diagnosis and treatment.

Areas of research include:

  • Studying the association of aspirin and statin medicines with a reduced risk of cholangiocarcinoma.
  • Investigating the molecular genetics of tumors and identifying biomarkers, which may aid in early diagnosis or lead to new targeted therapies.
  • Doing clinical trials for new targeted therapies. These trials are possible because of Mayo Clinic's high patient volume for primary sclerosing cholangitis and bile duct cancer.
  • Expanding surgical options and refining techniques, including vessel and bile duct reconstruction, to widen the number of people who may qualify for curative approaches.
  • Proving that the biomarker CA 19-9 is useful for staging cholangiocarcinoma and understanding the prognosis for people with the disease.

Publications

See a list of publications about cholangiocarcinoma by Mayo Clinic doctors on PubMed, a service of the National Library of Medicine.

Research Profiles

By Mayo Clinic Staff

Hilar cholangiocarcinoma care at Mayo Clinic

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Survival ratesCare at Mayo Clinic
Dec. 10, 2025
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Hilar cholangiocarcinoma

Research: It's all about patients

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Joseph Sirven, M.D., Professor of Neurology, Mayo Clinic: Mayo's mission is about the patient. The patient comes first. So the mission and research here is to advance how we can best help the patient, how to make sure the patient comes first in care. So in many ways, it's a cycle. It can start with as simple as an idea worked on in a laboratory, brought to the patient bedside, and if everything goes right — and let's say it's helpful or beneficial — then brought on as a standard approach. And I think that is one of the unique characteristics of Mayo's approach to research — that patient-centeredness — that really helps to put it in its own spotlight.