Factor V Leiden (FAK-tur five LIDE-n) is a mutation of one of the clotting factors in the blood. This mutation can increase your chance of developing abnormal blood clots, most commonly in your legs or lungs.

Most people with factor V Leiden never develop abnormal clots. But in people who do, these abnormal clots can lead to long-term health problems or become life-threatening.

Both men and women can have factor V Leiden. Women who carry the factor V Leiden mutation may have an increased tendency to develop blood clots during pregnancy or when taking the hormone estrogen.

If you have factor V Leiden and have developed blood clots, anticoagulant medications can lessen your risk of developing additional blood clots and help you avoid potentially serious complications.


The factor V Leiden mutation does not itself cause any symptoms. Since factor V Leiden is a risk for developing blood clots in the leg or lungs, the first indication that you have the disorder may be the development of an abnormal blood clot.

Some clots do no damage and disappear on their own. Others can be life-threatening. Symptoms of a blood clot depend on what part of your body is affected.

A clot in a deep vein

This is known as deep vein thrombosis (DVT), which most commonly occurs in the legs. A DVT may not cause any symptoms. If signs and symptoms do occur, they can include:

  • Pain
  • Swelling
  • Redness
  • Warmth

A clot that travels to your lungs

Known as a pulmonary embolism, this occurs when a portion of a DVT breaks free and travels through the right side of your heart to your lung, where it blocks blood flow. This can be a life-threatening situation. Signs and symptoms may include:

  • Sudden shortness of breath
  • Chest pain when breathing in
  • A cough that produces bloody or blood-streaked sputum
  • Rapid heartbeat

When to see a doctor

Seek medical attention immediately if you have signs or symptoms of either a DVT or a pulmonary embolism.


If you have factor V Leiden, you inherited either one copy or, rarely, two copies of the defective gene. Inheriting one copy slightly increases your risk of developing blood clots. Inheriting two copies — one from each parent — significantly increases your risk of developing blood clots.

Risk factors

A family history of factor V Leiden increases your risk of inheriting the disorder. The disorder is most common in people who are white and of European descent.

People who have inherited factor V Leiden from only one parent have a 5 percent chance of developing an abnormal blood clot by age 65. Factors that increase this risk include:

  • Two faulty genes. Inheriting the genetic mutation from both parents instead of just one can significantly increase your risk of abnormal blood clots.
  • Immobility. Extended periods of immobility, such as sitting during a long airplane flight, can increase the risk of leg clots.
  • Estrogens. Oral contraceptives, hormone replacement therapy and pregnancy can make you more likely to develop blood clots.
  • Surgeries or injuries. Surgeries or injuries such as broken bones can increase your risk of abnormal blood clots.
  • Non-O blood type. Abnormal blood clots are more common in people who have blood types of A, B or AB compared with those with blood type O.


Factor V Leiden can cause blood clots in the legs (deep vein thrombosis) and lungs (pulmonary embolism). These blood clots can be life-threatening.

Aug. 23, 2022

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  8. Barbara Woodward Lips Patient Education Center. Deep vein thrombosis and pulmonary embolism. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2017.


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