Diagnosis

Your doctor will ask you about your signs and symptoms, conduct a physical exam, and ask about your medical history. He or she may refer you to a kidney specialist (nephrologist) or a diabetes specialist (endocrinologist).

To determine whether you have diabetic kidney disease, you may need certain tests and procedures, such as:

  • Blood tests. If you have diabetes, you will need blood tests to monitor your condition and determine how well your kidneys are working.
  • Urine tests. Urine samples provide information about your kidney function and whether you have too much protein in the urine. High levels of a protein called microalbumin may indicate your kidneys are being affected by disease.
  • Imaging tests. Your doctor may use X-rays and ultrasound to assess your kidneys' structure and size. You may also undergo CT scanning and magnetic resonance imaging (MRI) to determine how well blood is circulating within your kidneys. Other imaging tests may be used in some cases.
  • Renal function testing. Your doctor can assess your kidneys' filtering capacity using renal analysis testing.
  • Kidney biopsy. Your doctor may recommend a kidney biopsy to remove a sample of kidney tissue. You'll be given a numbing medication (local anesthetic). Then your doctor will use a thin needle to remove small pieces of kidney tissue for examination under a microscope.

Treatment

The first step in treating diabetic nephropathy is to treat and control your diabetes and, if needed, high blood pressure (hypertension). With good management of your blood sugar and hypertension, you can prevent or delay kidney dysfunction and other complications.

Medications

In the early stages of the disease, your treatment plan may include various medications, such as those that help:

  • Control high blood pressure. Medications called angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs) are used to treat high blood pressure. Using both of these together isn't advised because of increased side effects. Studies support the goal of a blood pressure reading below 140/90 millimeters of mercury (mm Hg) depending on your age and overall risk of cardiovascular disease.
  • Manage high blood sugar. Several medications have been shown to help control high blood sugar in people with diabetic nephropathy. Studies support the goal of an average hemoglobin A1C of less than 7%.
  • Lower high cholesterol. Cholesterol-lowering drugs called statins are used to treat high cholesterol and reduce protein in the urine.
  • Foster bone health. Medications that help manage your calcium phosphate balance are important in maintaining healthy bones.
  • Control protein in urine. Medications can often reduce the level of the protein albumin in the urine and improve kidney function.

Your doctor may recommend follow-up testing at regular intervals to see whether your kidney disease remains stable or progresses.

Treatment for advanced diabetic kidney disease

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If your disease progresses to kidney failure (end-stage kidney disease), your doctor will help you transition to care focused on either replacing the function of your kidneys or making you more comfortable. Options include:

  • Kidney dialysis. This treatment is a way to remove waste products and extra fluid from your blood. The two main types of dialysis are hemodialysis and peritoneal dialysis. In the first, more common method, you may need to visit a dialysis center and be connected to an artificial kidney machine about three times a week, or you may have dialysis done at home by a trained caregiver. Each session takes three to five hours. The second method may be done at home as well.
  • Transplant. In some situations, the best option is a kidney transplant or a kidney-pancreas transplant. If you and your doctor decide on transplantation, you'll be evaluated to determine whether you're eligible for this surgery.
  • Symptom management. If you choose not to have dialysis or a kidney transplant, your life expectancy generally would be only a few months. You may receive treatment to help keep you comfortable.

Potential future treatments

In the future, people with diabetic nephropathy may benefit from treatments being developed using regenerative medicine. These techniques may help reverse or slow kidney damage caused by the disease. For example, some researchers think that if a person's diabetes can be cured by a future treatment such as pancreas islet cell transplant or stem cell therapy, kidney function may improve. These therapies, however, are still investigational.

In addition, researchers are testing in people stem cells and several new medications for diabetic nephropathy.

    Kidney Disease: How kidneys work, Hemodialysis, and Peritoneal dialysis

    Clinical trials

    Explore Mayo Clinic studies testing new treatments, interventions and tests as a means to prevent, detect, treat or manage this disease.

    Lifestyle and home remedies

    Lifestyle behaviors can support your treatment goals. Depending on your situation, kidney function and overall health, these actions may include:

    • Being active most days of the week. With your doctor's advice, aim for at least 30 minutes of physical activity most days of the week.
    • Adjusting your diet. Talk with a dietitian about limiting how much sodium is in your diet, choosing lower potassium foods and limiting the amount of protein you eat.
    • Quitting smoking. If you're a smoker, talk with your doctor about strategies for quitting smoking.
    • Maintaining a healthy weight. If you need to lose weight, talk with your doctor about weight-loss strategies, such as increasing daily physical activity and reducing calories.
    • Taking a daily aspirin. Talk with your doctor about whether a daily low-dose aspirin is right for you.
    • Being vigilant. Alert doctors unfamiliar with your medical history that you have diabetic nephropathy. They can take steps to protect your kidneys from further damage due to medical tests that use contrast dye (such as angiogram and computerized tomography scan).

      Also be able to recognize when you have a urinary tract infection and seek treatment promptly.

    Coping and support

    If you have diabetic nephropathy, here are some steps that may help you cope:

    • Connect with other people who have diabetes and kidney disease. Ask your doctor about support groups in your area. Or contact organizations such as the American Association of Kidney Patients, the National Kidney Foundation or the American Kidney Fund for groups in your area.
    • Maintain your normal routine, when possible. Try to maintain a normal routine, doing the activities you enjoy and continuing to work, if your condition allows. This may help you cope with feelings of sadness or loss that you may experience after your diagnosis.
    • Talk with someone you trust. Living with diabetic kidney disease can be stressful, and it may help to talk about your feelings. You may have a friend or family member who is a good listener. Or you may find it helpful to talk with a faith leader or someone else you trust. Consider asking your doctor for a referral to a social worker or counselor.

    Preparing for your appointment

    If you have signs and symptoms of kidney disease, make an appointment to see your doctor.

    What can you do

    Here's some information to help you prepare for your appointment.

    • Be aware of pre-appointment restrictions. When you make the appointment, ask if you need to do anything beforehand, such as limit your diet.
    • List your symptoms, including any that seem unrelated to your kidneys or urinary function.
    • List all medications, vitamins or supplements you take, including doses.
    • List key medical history, including a family history of diabetes or kidney disease.
    • Be prepared to discuss your diet and exercise habits. If you don't already eat well and exercise, be ready to talk with your doctor about challenges you might face in getting started.
    • Ask a family member or friend to come with you. He or she may hear something that you missed or forgot.
    • List questions to ask your doctor.

    For diabetic nephropathy, some basic questions to ask your doctor include:

    • What's the level of damage to my kidneys?
    • Is my kidney function worsening?
    • Do I need more tests?
    • What's causing my condition?
    • Can the damage to my kidneys be reversed?
    • What are my treatment options?
    • What are the potential side effects of each treatment?
    • I have other health conditions. How can I best manage them together?
    • Do I need to eat a special diet?
    • Can you refer me to a dietitian who can help me plan my meals?
    • Do I need to see a specialist?
    • Is there a generic alternative to the medicine you're prescribing?
    • Do you have any brochures or other printed material that I can have? What websites do you recommend?
    • How often do I need to schedule follow-up visits and testing?

    Don't hesitate to ask any other questions during your appointment as they occur to you.

    What to expect from your doctor

    Your doctor may ask you questions, such as:

    • Do you have diabetes or high blood pressure? If so, for how long?
    • Are you experiencing any symptoms, such as changes in your urinary habits or unusual fatigue?
    • How long have you had symptoms?
    • What, if anything, seems to improve your symptoms?
    • What, if anything, appears to worsen your symptoms?

    Diabetic nephropathy care at Mayo Clinic

    Sept. 19, 2019
    1. Diabetic kidney disease. National Institute of Diabetes and Digestive and Kidney Diseases. https://www.niddk.nih.gov/health-information/diabetes/overview/preventing-problems/diabetic-kidney-disease. Accessed April 29, 2019.
    2. Diabetic nephropathy. Merck Manual Professional Version. https://www.merckmanuals.com/professional/genitourinary-disorders/glomerular-disorders/diabetic-nephropathy. Accessed April 22, 2019.
    3. Goldman L, et al., eds. Diabetes and the kidney. In: Goldman-Cecil Medicine. 25th ed. Philadelphia, Pa.: Saunders Elsevier; 2016. https://www.clinicalkey.com. Accessed April 22, 2019.
    4. Goldman L, et al., eds. Approach to the patient with renal disease. In: Goldman-Cecil Medicine. 25th ed. Philadelphia, Pa.: Saunders Elsevier; 2016. https://www.clinicalkey.com. Accessed April 22, 2019.
    5. Elsevier Point of Care. Clinical Overview: Diabetic nephropathy. https://www.clinicalkey.com. Accessed April 22, 2019.
    6. Bakris GL. Overview of diabetic nephropathy. https://www.uptodate.com/contents/search. Accessed April 29, 2019.
    7. Bakris GL. Treatment of diabetic nephropathy. https://www.uptodate.com/contents/search. Accessed April 22, 2019.
    8. American Diabetes Association. Microvascular complications and foot care: Standards of Medical Care in Diabetes — 2019. Diabetes Care. 2019;42:S124.
    9. AskMayoExpert. Diabetic nephropathy (adult). Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2018.
    10. Diabetes and chronic kidney disease. National Kidney Foundation. https://www.kidney.org/news/newsroom/factsheets/Diabetes-And-CKD. Accessed April 25, 2019.
    11. Coping effectively: A guide for patients and their families. National Kidney Foundation. https://www.kidney.org/atoz/coping-effectively-guide-patients-and-their-families. Accessed April 23, 2019.
    12. Robertson RP. Pancreas and islet cell transplantation in diabetes mellitus. https://www.uptodate.com/contents/search. Accessed April 26, 2019.
    13. Skorecki K, et al., eds. Diabetic nephropathy. In: Brenner & Rector's The Kidney. 10th ed. Philadelphia, Pa.: Elsevier; 2016. https://www.clinicalkey.com. Accessed April 26, 2019.
    14. Keeping kidneys safe: Smart choices about medicines. National Institute of Diabetes and Digestive and Kidney Diseases. https://www.niddk.nih.gov/health-information/kidney-disease/keeping-kidneys-safe. Accessed April 29, 2019.
    15. Sethi S, et al. Mayo Clinic/Renal Pathology Society consensus report on pathologic classification, diagnosis, and report of GN. Journal of the American Society of Nephrology. 2015;27:1.
    16. Morrow ES. Allscripts EPSi. Mayo Clinic, Rochester, Minn. April 29, 2019.
    17. Schwartz GL (expert opinion). Mayo Clinic, Rochester, Minn. May 28, 2019.

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