Chondrosarcoma is a rare type of cancer that usually begins in the bones, but can sometimes occur in the soft tissue near bones. Chondrosarcoma happens most often in the pelvis, hip and shoulder. More rarely, it can happen in the bones of the spine.
Most chondrosarcomas grow slowly and may not cause many signs and symptoms at first. Some rare types grow rapidly and have a high risk of spreading to other areas of the body, which can make these cancers difficult to treat.
Chondrosarcoma treatment usually involves surgery. Other options might include radiation therapy and chemotherapy.
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Chondrosarcoma tends to grow slowly, so it might not cause signs and symptoms at first. When they occur, signs and symptoms of chondrosarcoma may include:
- Increasing pain
- A growing lump or area of swelling
- Weakness or bowel and bladder control problems, if the cancer presses on the spinal cord
It's not clear what causes chondrosarcoma. Doctors know that cancer begins when a cell develops changes (mutations) in its DNA. A cell's DNA contains the instructions that tell it what to do. The instructions tell the cell to multiply quickly and to continue living when healthy cells would die. The accumulating cells form a tumor that can grow to invade and destroy normal body tissue. In time, cells can break away and spread (metastasize) to other areas of the body.
Factors that can increase the risk of chondrosarcoma include:
- Increasing age. Chondrosarcoma occurs most often in middle-aged and older adults, though it can occur at any age.
- Other bone diseases. Ollier's disease and Maffucci's syndrome are conditions that cause noncancerous bone growths (enchondromas) in the body. These growths sometimes transform into chondrosarcoma.
Chondrosarcoma care at Mayo Clinic
Dec. 07, 2022
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- Azar FM, et al. Malignant tumors of bone. In: Campbell's Operative Orthopaedics. 14th ed. Elsevier; 2021. https://www.clinicalkey.com. Accessed March 18, 2021.
- Winn RH, ed. Chordomas and chondrosarcomas. In: Youmans and Winn Neurological Surgery. 7th ed. Elsevier; 2017. https://www.clinicalkey.com. Accessed March 18, 2021.
- Bone cancer. National Comprehensive Cancer Network. https://www.nccn.org/guidelines/guidelines-detail?category=1&id=1418. Accessed March 18, 2021.
- Dierselhuis EF, et al. Intralesional treatment versus wide resection for central low-grade chondrosarcoma of the long bones. Cochrane Database of Systematic Reviews. 2019; doi:10.1002/14651858.CD010778.pub2.
- Unni KK, et al. Chondrosarcoma (primary, secondary, dedifferentiated and clear cell). In: Dahlin's Bone Tumors. 6th ed. Lippincott Williams & Wilkins; 2010.
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