Calciphylaxis (kal-sih-fuh-LAK-sis) is a serious, uncommon disease in which calcium accumulates in small blood vessels of the fat and skin tissues. Calciphylaxis causes painful skin ulcers and may cause serious infections that can lead to death.

People who have calciphylaxis usually have kidney failure and are on dialysis or recently had a kidney transplant. The condition can also occur in people without kidney disease.

Calciphylaxis care at Mayo Clinic

June 18, 2015
  1. Santos PW, et al. Calciphylaxis (calcific uremic arteriolopathy). http://www.uptodate.com/home. Accessed May 7, 2015.
  2. AskMayoExpert. How is calciphylaxis treated? Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2014.
  3. AskMayoExpert. What tests are used to diagnose calciphylaxis? Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2014.
  4. Nigwekar SU, et al. Calciphylaxis: Risk factors, diagnosis, and treatment. American Journal of Kidney Diseases. In press. Accessed May 13, 2015.
  5. Wangen T, et al. Calciphylaxis: An unusual case with an unusual outcome. The American Journal of Nursing. 2014;114:24.
  6. Brandenburg VM, et al. Calciphylaxis in CKD and beyond. Nephrology Dialysis Transplantation. 2012;27:1314.
  7. Vedvyas C, et al. Calciphylaxis: A systematic review of existing and emerging therapies. Journal of the American Academy of Dermatology. 2012;67:e253.
  8. El-Azhary RA, et al. Retrospective analysis of tissue plasminogen activator as an adjuvant treatment for calciphylaxis. JAMA Dermatology. 2013;149:63.
  9. El-Azhary RA (expert opinion). Mayo Clinic, Rochester, Minn. June 6, 2015.
  10. Sluzevich JC (expert opinion). Mayo Clinic, Jacksonville, Fla. May 26, 2015.