The following tests can help diagnose aplastic anemia:
- Blood tests. Normally, red blood cell, white blood cell and platelet levels stay within certain ranges. In aplastic anemia all three of these blood cell levels are low.
- Bone marrow biopsy. A doctor uses a needle to remove a small sample of bone marrow from a large bone in your body, such as your hipbone. The sample is examined under a microscope to rule out other blood-related diseases. In aplastic anemia, bone marrow contains fewer blood cells than normal. Confirming a diagnosis of aplastic anemia requires a bone marrow biopsy.
Bone marrow exam
Once you've received a diagnosis of aplastic anemia, you might need other tests to determine the cause.
Treatments for aplastic anemia, which will depend on the severity of your condition and your age, might include observation, blood transfusions, medications, or bone marrow transplantation. Severe aplastic anemia, in which your blood cell counts are extremely low, is life-threatening and requires immediate hospitalization.
Although not a cure for aplastic anemia, blood transfusions can control bleeding and relieve symptoms by providing blood cells your bone marrow isn't producing. You might receive:
- Red blood cells. These raise red blood cell counts and help relieve anemia and fatigue.
- Platelets. These help prevent excessive bleeding.
While there's generally no limit to the number of blood transfusions you can have, complications can sometimes arise with multiple transfusions. Transfused red blood cells contain iron that can accumulate in your body and can damage vital organs if an iron overload isn't treated. Medications can help rid your body of excess iron.
Over time your body can develop antibodies to transfused blood cells, making them less effective at relieving symptoms. The use of immunosuppressant medication makes this complication less likely.
Stem cell transplant
A stem cell transplant to rebuild the bone marrow with stem cells from a donor might be the only successful treatment option for people with severe aplastic anemia. A stem cell transplant, also called a bone marrow transplant, is generally the treatment of choice for people who are younger and have a matching donor — most often a sibling.
If a donor is found, your diseased bone marrow is first depleted with radiation or chemotherapy. Healthy stem cells from the donor are filtered from the blood. The healthy stem cells are injected intravenously into your bloodstream, where they migrate to the bone marrow cavities and begin creating new blood cells.
The procedure requires a lengthy hospital stay. After the transplant, you'll receive drugs to help prevent rejection of the donated stem cells.
A stem cell transplant carries risks. Your body may reject the transplant, leading to life-threatening complications. In addition, not everyone is a candidate for transplantation or can find a suitable donor.
For people who can't undergo a bone marrow transplant or for those whose aplastic anemia is due to an autoimmune disorder, treatment can involve drugs that alter or suppress the immune system (immunosuppressants).
Drugs such as cyclosporine (Gengraf, Neoral, Sandimmune) and anti-thymocyte globulin suppress the activity of immune cells that are damaging your bone marrow. This helps your bone marrow recover and generate new blood cells. Cyclosporine and anti-thymocyte globulin are often used together.
Corticosteroids, such as methylprednisolone (Medrol, Solu-Medrol), are often used with these drugs.
Although effective, these drugs further weaken your immune system. It's also possible for anemia to return after you stop these drugs.
Bone marrow stimulants
Certain drugs — including colony-stimulating factors, such as sargramostim (Leukine), filgrastim (Neupogen) and pegfilgrastim (Neulasta), epoetin alfa (Epogen/Procrit), and eltrombopag (Promacta) — help stimulate the bone marrow to produce new blood cells. Growth factors are often used with immune-suppressing drugs.
Having aplastic anemia weakens your immune system, which leaves you more prone to infections.
If you have aplastic anemia, see your doctor at the first sign of infection, such as a fever. You don't want the infection to get worse, because it could prove life-threatening. If you have severe aplastic anemia, your doctor might prescribe antibiotics or antiviral medications to help prevent infections.
Aplastic anemia caused by radiation and chemotherapy treatments for cancer usually improves after those treatments stop. The same is true for most other drugs that induce aplastic anemia.
Pregnant women with aplastic anemia are treated with blood transfusions. For many women, pregnancy-related aplastic anemia improves once the pregnancy ends. If that doesn't happen, treatment is still necessary.
If you have aplastic anemia, take care of yourself by:
- Resting when you need to. Anemia can cause fatigue and shortness of breath with even mild exertion. Take a break and rest when you need to.
- Avoiding contact sports. Because of the risk of bleeding associated with a low platelet count, avoid activities that can cause a cut or fall.
- Protecting yourself from germs. Wash your hands frequently and avoid sick people. If you develop a fever or other indicators of an infection, see your doctor for treatment.
Coping and support
Tips to help you and your family better cope with your illness include:
- Research your disease. The more you know, the better prepared you'll be to make treatment decisions.
- Ask questions. Be sure to ask your doctor about anything related to your disease or treatment that you don't understand. It might help you to record or write down what your doctor tells you.
- Be vocal. Don't be afraid to express your concerns to your doctor or other health care professionals treating you.
- Seek support. Ask family and friends for emotional support. Ask them to consider becoming blood donors or bone marrow donors. It might help to talk to others coping with the disease. Ask your doctor if he or she knows of local support groups, or contact the Aplastic Anemia and MDS International Foundation. It offers a peer support network and can be reached at 800-747-2820.
- Take care of yourself. Proper nutrition and sleep are important to optimize blood production.
Preparing for your appointment
Start by making an appointment with your primary care doctor. He or she might then refer you to a doctor who specializes in treating blood disorders (hematologist). If aplastic anemia comes on suddenly, your treatment might begin in the emergency room.
Here's some information to help you get ready for your appointment.
What you can do
Make a list of:
- Your symptoms and when they began
- Key personal information, including any recent life changes, such as a new job, particularly one that exposes you to chemicals
- Medications, vitamins and other supplements you take, including doses
- Questions to ask your doctor
Take a family member or a friend with you to your doctor, if possible, to help you remember the information you're given.
For aplastic anemia, questions to ask your doctor include:
- What's the most likely cause of my symptoms?
- Are there other possible causes for my symptoms?
- What's my prognosis?
- What treatments are available, and which do you recommend?
- Are there alternatives to the primary approach that you're suggesting?
- I have another health condition. How can I best manage them together?
- Do you have brochures or other printed material I can have? What websites do you recommend?
What to expect from your doctor
Your doctor is likely to ask you questions, such as:
- Have you had recent infections?
- Have you bled unexpectedly?
- Are you more tired than usual?
- Does anything seem to improve your symptoms?
- Does anything appear to worsen your symptoms?
Feb 11, 2022
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- Olson TS. Aplastic anemia: Pathogenesis; clinical manifestations; and diagnosis. https://www.uptodate.com/contents/search. Accessed Nov. 16, 2019.
- Aplastic anemia. National Heart, Lung, and Blood Institute. https://www.nhlbi.nih.gov/health-topics/aplastic-anemia. Accessed Nov. 16, 2019.
- Olson TS. Treatment of aplastic anemia in adults. https://www.uptodate.com/contents/search. Accessed Nov. 16, 2019.
- Aplastic anemia. Aplastic Anemia and MDS International Foundation. https://www.aamds.org/diseases/aplastic-anemia. Accessed Nov. 16, 2019.
- DeZern AE, et al. Haploidentical donor bone marrow transplantation for severe aplastic anemia. Hematology/Oncology Clinics of North America. 2018; doi:10.1016/j.hoc.2018.04.001.