Jan. 28, 2016
Below are current clinical trials.5 studies in Acute lymphocytic leukemia
(open studies only).
Filter this list of studies by location, status and more.
The purpose of this study is to compare the effect of a blood thinning drug called Apixaban versus no administration of a blood thinning drug, in preventing blood clots in children with leukemia or lymphoma. Patients must be receiving chemotherapy; including Pegylated L-Asparaginase and have a central line (a catheter inserted for administration of medications and blood sampling).
The purpose of this study is to determine the safety and effectiveness of KTE-C19, an anti-CD19 antigen T cell therapy, for the treatment of children or adolescents who have B-precursor type acute lymphoblastic leukemia that has returned or is resistant to treatment.
This randomized phase III trial studies combination chemotherapy with blinatumomab to see how well it works compared to induction chemotherapy alone in treating patients with newly diagnosed breakpoint cluster region (BCR)-c-abl oncogene 1, non-receptor tyrosine kinase (ABL)-negative B lineage acute lymphoblastic leukemia. Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Monoclonal antibodies, such as blinatumomab, may block cancer growth in different ways by targeting certain cells. It is not yet known whether combination chemotherapy is more effective with or without blinatumomab in treating newly diagnosed acute lymphoblastic leukemia.
This clinical trial is studying long-term follow-up in patients who are or have participated in Children's Oncology Group studies. Developing a way to track patients enrolled in Children's Oncology Group studies will help doctors gather long-term follow-up information and may help the study of cancer in the future.
Scottsdale/Phoenix, Ariz., Jacksonville, Fla., Rochester, Minn.
GRAIL is using deep sequencing of circulating cell-free nucleic acids (cfNAs) to develop assays to detect cancer early in blood. The purpose of this study is to collect biological samples from donors with a new diagnosis of cancer (blood and tumor tissue) and from donors who do not have a diagnosis of cancer (blood) in order to characterize the population heterogeneity in cancer and non-cancer subjects and to develop models for distinguishing cancer from non-cancer.
- Hoffman R, et al. Clinical manifestations and treatment of acute lymphoblastic leukemia in children. In: Hematology: Basic Principles and Practice. 6th ed. Philadelphia, Pa.: Saunders Elsevier; 2013. http://www.clinicalkey.com. Accessed March 18, 2015.
- Niederhuber JE, et al., eds. Childhood leukemia. In: Abeloff's Clinical Oncology. 5th ed. Philadelphia, Pa.: Churchill Livingstone Elsevier; 2014. http://www.clinicalkey.com. Accessed March 18, 2015.
- Childhood acute lymphoblastic leukemia treatment (PDQ). National Cancer Institute. http://www.cancer.gov/types/leukemia/patient/child-all-treatment-pdq#section/all. Accessed June 5, 2015.
- Adult acute lymphoblastic leukemia treatment (PDQ). National Cancer Institute. http://www.cancer.gov/types/leukemia/hp/adult-all-treatment-pdq#section/all. Accessed May 18, 2015.
- Integrative medicine & complementary and alternative therapies as part of blood cancer care. Leukemia & Lymphoma Society. http://www.lls.org/#/resourcecenter/freeeducationmaterials/treatment/integrativemedandcam. Accessed March 18, 2015.
- Larson RA. Treatment of relapsed or refractory acute lymphoblastic leukemia in adults. http://www.uptodate.com/home. Accessed May 18, 2015.
- Mesa RA (expert opinion). Mayo Clinic, Phoenix/Scottsdale, Ariz. May 30, 2015.
- Cook AJ. Decision Support System. Mayo Clinic, Rochester, Minn. March 17, 2015.
- Hoffman R, et al. Acute lymphoblastic leukemia in adults. In: Hematology: Basic Principles and Practice. 6th ed. Philadelphia, Pa.: Saunders Elsevier; 2013. http://www.clinicalkey.com. Accessed March 18, 2015.
- Niederhuber JE, et al., eds. Acute leukemias in adults. In: Abeloff's Clinical Oncology. 5th ed. Philadelphia, Pa.: Churchill Livingstone Elsevier; 2014. http://www.clinicalkey.com. Accessed March 18, 2015.
- Blincyto (prescribing information). Thousand Oaks, Calif.: Amgen Inc.; 2014. http://www.blincyto.com/?WT.srch=1. Accessed March 17, 2015.