Transplant Center

Below are current clinical trials.

Filter this list of studies by location, status and more.

1. A Study to Examine Diabetes Control and Patient Reported Outcomes Among Kidney Transplant Recipients with Type 2 Diabetes

   Rochester, Minn.

   This study aims to measure the percentage of time spent in hyperglycemia in patients on insulin therapy and evaluate diabetes related patient reported outcomes in kidney transplant recipients with type 2 diabetes. It also aimes to evaluate immunosuppression related patient reported outcomes in kidney transplant recipients with type 2 diabetes.

2. A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of TRK-250 for Patients With Idiopathic Pulmonary Fibrosis

   Jacksonville, Fla.

   The purpose of this study is to assess the safety and tolerability of single- and multiple-inhaled doses of TRK-250 in subjects with idiopathic pulmonary fibrosis (IPF).

   TRK-250 is a nucleic acid medicine that inhibits the progression of pulmonary fibrosis by selectively suppressing the expression of transforming growth factor-beta 1 (TGF-β1) protein, at the gene expression level.

3. A Study to Determine the Safety, Tolerability and Effect on Liver Histologic Parameters of ARO-AAT

   Scottsdale/Phoenix, Ariz.

   The purpose of this study is to evaluate the safety, tolerability and effect on liver histologic parameters with administration of the investigational product, ARO-AAT, in participants with alpha-1 antitrypsin deficiency (AATD). Participants will receive multiple subcutaneous doses of ARO-AAT.

4. Ultrasound Microvessel Imaging of Transplant Kidney

   Rochester, Minn.

   The purpose of this study is to investigate the value of ultrasound microvessel imaging for evaluation of transplant kidney health.

5. Donor-Specific Cell Free DNA Monitoring of Thoracic Allografts

   Rochester, Minn., Jacksonville, Fla.

   The purpose of this study is to determine if DNA originating from the transplanted heart or lung can be detected in the blood and used to monitor for rejection.

6. A Study to Analyze Tacrolimus Metabolism in Heart Transplant Patients

   Jacksonville, Fla.

   The puprose of this study is to evaluate pharmacogenomic differences of CYP 3A5 in heart transplant patients, to determine dose ranges and pharmacodynamics properties of tacrolimus metabolism based on CYP 3A5 genotype/phenotype combinations, and to assess whether CYP3A5 polymorphism influences post-transplant outcomes including survival, rejection and infection rates.

7. Authorizaton to Use Clincially Obtained Data for Research

   Rochester, Minn.

   This study is being done to gather information regarding your health in relation to your composite tissue transplant. We would like to use your medical records (both existing and future) to study the health of patients who will receive or have received a composite tissue transplant. This research would include looking at your demographic information, cause of initial injury, laboratory test results and medical exams relating to your pre and post transplant care, and your mental well-being before and after transplant.

    

8. A Study to Develop a Database of Pancreas Transplant Recipients, to Form a Larger Cohort for Future Research

   Rochester, Minn.

   The purpose of this study is to form a database collection of pancreas transplant recipients, of a large enough size that further studies can be carried out. The data collected will be shared and received by all institutions.

9. Study of Blood Pressure Evaluation with Continuous Flow Left Ventricular Assist Devices

   Jacksonville, Fla.

   The primary purpose of this study is to evaluate the ability for tonometry to accurately reproduce blood pressure readings in patients with left ventricular assist devices (LVAD).

10. Trimethoprim-sulfamethoxazole Graded Administration in Oncology, Hematopoietic Stem Cell Transplant, and Solid Organ Transplant Patients with a History of Sulfonamide Allergy

    Rochester, Minn.

    The aim of this study is to study the efficacy and safety of our short and long one-day protocols for TMP-SMX graded administration in hematologic malignancy, hematopoietic stem cell transplant, and solid organ transplant patients.