Clinical trials Below are current clinical trials.76 studies in Transplant Center (open studies only). Filter this list of studies by location, status and more. A Study to Evaluate Ruxolitinib for the Treatment of Graft-Versus-Host Disease Following Allogeneic Hematopoietic Stem Cell Transplant Scottsdale/Phoenix, Ariz. The purpose of this study is to provide ruxolitinib through an expanded access program for the treatment of graft-versus-host disease (GVHD) in United States to patients who are ineligible or unable to participate in any actively enrolling Incyte-sponsored clinical studies for ruxolitinib in the treatment of GVHD. A Study to Evaluate Itacitinib for Low Risk Graft-vs-Host Disease (GVHD) Rochester, Minn. The purpose of this study is to test whether patients with low risk Great-vs-Host Disease (GVHD) can be successfully treated without steroids. Patients who participate with this study will be treated with itacitinib instead of steroids. Itacitinib is an experimental drug with an excellent safety record and appears to have activity as a GVHD treatment. A new blood test can identify patients whose GVHD is most likely to respond to well to treatment (low risk GVHD). A Study to Evaluate Tacrolimus/Methotrexate versus Post-Transplant Cyclophosphamide/ Tacrolimus/Mycophenolate Mofetil in Non-Myeloablative/Reduced Intensity Conditioning Allogeneic Peripheral Blood Stem Cell Transplantation Rochester, Minn. The primary purpose of this study is to compare 1 year graft-versus-host disease (GVHD)-free, graft relapse-free survival (GRFS) between the two GVHD prophylaxis regimens. Donor-Specific Cell Free DNA Monitoring of Thoracic Allografts Rochester, Minn., Jacksonville, Fla. The purpose of this study is to determine if DNA originating from the transplanted heart or lung can be detected in the blood and used to monitor for rejection. A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of TRK-250 for Patients With Idiopathic Pulmonary Fibrosis Jacksonville, Fla. The purpose of this study is to assess the safety and tolerability of single- and multiple-inhaled doses of TRK-250 in subjects with idiopathic pulmonary fibrosis (IPF). TRK-250 is a nucleic acid medicine that inhibits the progression of pulmonary fibrosis by selectively suppressing the expression of transforming growth factor-beta 1 (TGF-β1) protein, at the gene expression level. Authorizaton to Use Clincially Obtained Data for Research Rochester, Minn. This study is being done to gather information regarding your health in relation to your composite tissue transplant. We would like to use your medical records (both existing and future) to study the health of patients who will receive or have received a composite tissue transplant. This research would include looking at your demographic information, cause of initial injury, laboratory test results and medical exams relating to your pre and post transplant care, and your mental well-being before and after transplant. A Study to Develop a Database of Pancreas Transplant Recipients, to Form a Larger Cohort for Future Research Rochester, Minn. The purpose of this study is to form a database collection of pancreas transplant recipients, of a large enough size that further studies can be carried out. The data collected will be shared and received by all institutions. A Study to Analyze Tacrolimus Metabolism in Heart Transplant Patients Jacksonville, Fla. The puprose of this study is to evaluate pharmacogenomic differences of CYP 3A5 in heart transplant patients, to determine dose ranges and pharmacodynamics properties of tacrolimus metabolism based on CYP 3A5 genotype/phenotype combinations, and to assess whether CYP3A5 polymorphism influences post-transplant outcomes including survival, rejection and infection rates. Study of Blood Pressure Evaluation with Continuous Flow Left Ventricular Assist Devices Jacksonville, Fla. The primary purpose of this study is to evaluate the ability for tonometry to accurately reproduce blood pressure readings in patients with left ventricular assist devices (LVAD). A Study to Evaluate Cardiopulmonary Exercise Testing in Liver Transplant Candidates Scottsdale/Phoenix, Ariz. The purpose of this study is to determine agreement between cardiopulmonary exercise testing and cardiac stress testing (SOC) for the identification of subclinical coronary artery disease in liver transplant candidates, to determine agreement between cardiopulmonary exercise testing and dobutamine stress echocardiogram (SOC) for the identification of cirrhotic cardiomyopathy in liver transplant candidates, and to determine agreement between peak oxygen consumption from cardiopulmonary exercise testing and the liver frailty index or the six-minute walk test (SOC), for the identification of frailty in liver transplant candidates. 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