Pulmonary Medicine

Below are current clinical trials.

Filter this list of studies by location, status and more.

1. Impulse Oscillometry in Idiopathic Subglottic StenosisCap

   Rochester, Minn.

   The purpose of this study is to describe impulse oscillometry (IOS) in patients with symptomatic idiopathic subglottic stenosis (iSGS). The study will also compare IOS findings in patients with iSGS with IOS findings in patients with small airways obstruction and in healthy controls.

    

2. A Study to Evaluate the Safety and Effectiveness of Inhaled Treprostinil in Patients With Pulmonary Hypertension Due to Chronic Obstructive Pulmonary Disease (PH-COPD)

   Jacksonville, Fla.

   The primary purpose of this study is to demonstrate the safety and effectiveness of ozanimod compared to placebo on the maintenance of clinical remission and endoscopic response.

3. A Study of Beta-Blockers for the Prevention of Acute Worsening of Chronic Obstructive Pulmonary Disease

   Rochester, Minn.

   The purpose of this study is to assess the effect of metoprolol for patients who have moderate to severe COPD, measuring the time to first acute exacerbation (episode of worsening), the rates and severity of exacerbations, any cardiovascular events, all-causes of death, lung function, difficulty breathing, quality of life and any metoprolol-related side effects.

4. Investigation of the Safety and Pharmacology of Dry Powder Inhalation of Treprostinil

   Jacksonville, Fla.

   The primary objective of this study is to evaluate the long-term safety and tolerability of LIQ861, a dry powder formulation of treprostinil, in patients with Pulmonary Arterial Hypertension (PAH). A secondary objective of this study is to evaluate the comparative bioavailability of treprostinil between two formulations of inhaled therapy.

5. A One-Time DNA Study for Vasculitis

   Rochester, Minn.

   The purpose of this study is to identify genes that increase the risk of developing vasculitis, a group of severe diseases that feature inflammation of blood vessels. Results of these studies will provide vasculitis researchers with insight into the causes of these diseases and generate new ideas for diagnostic tests and therapies, and will be of great interest to the larger communities of researchers investigating vasculitis and other autoimmune, inflammatory, and vascular diseases.

6. Influence of Immunosuppresion on Lung Iron Content in Pneumonia

   Scottsdale/Phoenix, Ariz.

   The purpose of the study is to see whether lung concentrations of iron and a protein that binds iron are influenced by the presence of pneumonia. Increased amounts of iron in the lungs may promote the growth or microorganisms and may influence the severity of lung injury caused by an infection. We are comparing the amount of iron that accumulates in the lungs in response to pneumonia in different types of patients.

7. Decision Aid for Shared Decision Making in Acute Respiratory Failure

   Rochester, Minn.

   The purpose of this study is to develop, in close collaboration with stakeholders, an evidence-based decision aid for patients with acute respiratory failure.  To evaluate the impact of the decision aid on patient-important outcomes. We will conduct a prospective trial assessing the impact of the decision aid (vs. usual specialist care) on patient knowledge, patient involvement in decision-making, decision quality, treatment choice, and patient outcomes.

8. Patient Centered Outcomes for Life Support RETROSPECTIVE

   Rochester, Minn.

   The purpose of this study is to identify and prioritize outcomes and burdens of treatment that are important to patients and families when making decisions to start versus withhold or continue versus withdraw life support in the intensive care unit.

    

    

9. A Study to Develop a Decision Aid for Patients Having Lung Screening

   Rochester, Minn.

   The purpose of this study is to collect data and then design a decision aid for patients who are having a lung screening.

10. MARK 1A Series: Percutaneous Microwave Ablation for Patients With Lung Tumor(s)

    Rochester, Minn.

    The purpose of this study is to evaluate if lung ablation improves clinical outcomes for patients deemed to be surgically high-risk.