Mayo Clinic's pain medicine specialists are experts in helping adults and children with a wide range of painful disorders. They listen to your concerns and develop an individualized treatment plan to make sure you get the right therapy when you need it.

For people with complicated medical histories and multidimensional pain syndromes, treatment may be multifaceted and require complex interventions. Mayo Clinic's dedicated team of pain medicine experts carry out tens of thousands of procedures and surgeries each year. These doctors are experienced with the full range of options, including drug treatment, pain rehabilitation and management, injection therapies, and implantable pain management devices — such as spinal cord stimulators. Pediatric pain rehabilitation programs are offered at Mayo Clinic's campus in Minnesota.

A team approach focused on you

Your doctor talks with you and answers your questions. He or she may consult with specialists in anesthesiology, neurology, neurosurgery, orthopedic surgery, sports medicine, physical medicine and rehabilitation, psychiatry and psychology, or other areas to determine the best treatment for you. Your care team may also include physician assistants, nurse practitioners, registered nurses and clinical assistants — all working together in a focused effort on your treatment plan.

Mayo Clinic's multidisciplinary approach means your test results are available quickly and appointments are scheduled in coordination. What might take months elsewhere can often be done in days here.

Advanced diagnosis and treatment

The pain medicine team at Mayo Clinic includes doctors with advanced training (fellowship-trained experts) in anesthesiology, physical medicine and rehabilitation and neurology. Some have subspecialty expertise in ultrasonography, fluoroscopy, facial pain, neurostimulation, palliative care, peripheral nerve stimulation and regenerative medicine.

Mayo Clinic pain medicine doctors offer the complete spectrum of advanced pain management therapies. These include the latest in interventional and injection therapies, medication evaluation and recommendation, rehabilitative approaches, implantable pain management devices, and regenerative therapies, such as platelet-rich plasma and stem cell injections.

The combination of care providers from different backgrounds and access to a wide variety of treatment options ensure you receive comprehensive, innovative, supportive care and a treatment plan tailored to you.

Applying research to improve care

Mayo Clinic doctors and scientists seek new knowledge to improve therapies — including regenerative medicine approaches — for people with chronic pain conditions. For example, one research group is looking at how stem cells can be used to repair damaged tissue in the disks of the spine. Because Mayo Clinic's pain medicine doctors are involved in research, they offer advanced therapies that are available at very few medical centers.

In addition, pain medicine doctors at Mayo Clinic are committed to conducting clinical research to improve diagnosis and treatment options for people with painful disorders. Talk with your doctor about innovative clinical trials that you might be eligible for.

Mayo Clinic in Rochester, Minnesota, Mayo Clinic in Phoenix/Scottsdale, Arizona, and Mayo Clinic in Jacksonville, Florida, are ranked among the Best Hospitals for neurology and neurosurgery in the U.S. News & World Report Best Hospitals rankings.

Mayo Clinic in Rochester, Minnesota, Mayo Clinic in Jacksonville, Florida, and Mayo Clinic in Phoenix/Scottsdale, Arizona, are ranked among the Best Hospitals for cancer care by U.S. News & World Report. Mayo Clinic Children's Center in Rochester is ranked the No. 1 hospital in Minnesota, and the five-state region of Iowa, Minnesota, North Dakota, South Dakota and Wisconsin, according to U.S. News & World Report's 2023–2024 "Best Children's Hospitals" rankings.

Mayo Clinic pain medicine specialists treat a wide range of conditions, including the following. Not all services are available at each location. Please confirm when you request an appointment.

Mayo Clinic pain medicine specialists offer a full range of medical treatments and surgical services and procedures, though not all services are available at each location. Please confirm when you request an appointment.

Mayo Clinic has one of the largest and most experienced practices in the United States, with campuses in Arizona, Florida and Minnesota. Staff skilled in dozens of specialties work together to ensure quality care and successful recovery.

Find doctors and medical staff:

Research is an integral part of the Mayo Clinic mission. Specialists in pain medicine are often involved in research projects, including clinical and basic science research.

Areas of research include:

  • Stem cell therapy for disk-related back pain
  • Platelet-rich plasma injection for back pain
  • Neurostimulation for pain related to complications of diabetes
  • Use of ultrasound guidance for skull-base injections that ease pain

Clinical trials

Mayo Clinic researchers conduct clinical trials to find new ways to treat pain. You may have the opportunity to participate in such trials, which give you the chance to try experimental treatments. Learn more about current pain medicine clinical trials at Mayo Clinic.

Laboratories that research pain medicine

Center for Regenerative Biotherapeutics


See a list of publications about pain medicine topics by Mayo Clinic doctors on PubMed, a service of the National Library of Medicine.

Our patients tell us that the quality of their interactions, our attention to detail and the efficiency of their visits mean health care like they've never experienced. See the stories of satisfied Mayo Clinic patients.

Mayo Clinic has major campuses in Phoenix and Scottsdale, Arizona; Jacksonville, Florida; and Rochester, Minnesota. The Mayo Clinic Health System has dozens of locations in several states.

For more information on visiting Mayo Clinic, choose your location below:

Mayo Clinic works with hundreds of insurance companies and is an in-network provider for millions of people.

In most cases, Mayo Clinic doesn't require a physician referral. Some insurers require referrals, or may have additional requirements for certain medical care. All appointments are prioritized on the basis of medical need.

Learn more about appointments at Mayo Clinic.

Please contact your insurance company to verify medical coverage and to obtain any needed authorization prior to your visit. Often, your insurer's customer service number is printed on the back of your insurance card.