Below are current clinical trials.
17 studies in Orthopedic Surgery (open studies only).
Filter this list of studies by location, status and more.
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Rochester, Minn.
A Study to Compare Bone Ultrasound to Xrays for the Evaluation of Forearm Fracture Healing
Study type:
Observational What is this?
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
About this study
The purpose of this study is to compare the use of ultrasound to traditional xrays to evaluate fracture healing over time in patients with radius/ulna (arm) fractures.
Participating Mayo Clinic locations
Study statuses change often. Please contact us for help.
Print study details
Site IRB:
- Rochester, Minnesota: 15-008523
NCT ID:
NCT02769117Sponsor Protocol Number:
15-008523
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Rochester, Minn.
A Study Using Ultrasound to Detect the Subsynovial Connective Tissue Thickness and Motion in individuals with and without Carpal Tunnel Syndrome
Study type:
Observational What is this?
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
About this study
This study evaluates the ability of ultrasound to measure the movement of tendons and nerves within the human carpal tunnel.
Participating Mayo Clinic locations
Study statuses change often. Please contact us for help.
Print study details
Site IRB:
- Rochester, Minnesota: 06-002950
NCT ID:
NCT02747836Sponsor Protocol Number:
06-002950 00
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Rochester, Minn.
Preservation of Joint Function Using Postoperative Continuous Passive Motion (CPM) A Pilot Study
Study type:
Interventional What is this?
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
About this study
This pilot study is designed to determine if the rehabilitative benefits of continuous passive motion (CPM) will help preserve/restore the joint function and significantly improve the rate of recovery of patients after the surgical release of elbow contractures better than standard physiotherapy and static splinting.
Participating Mayo Clinic locations
Study statuses change often. Please contact us for help.
Print study details
Site IRB:
- Rochester, Minnesota: 11-000601
NCT ID:
NCT01420887Sponsor Protocol Number:
11-000601
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Rochester, Minn.
A Study of Giving Celecoxib and Dexamethasone with Manipulation Under Anesthesia to Treat Postoperative Stiffness after Total Knee Replacement Surgery
Study type:
Interventional What is this?
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
About this study
The purpose of this study is to compare the outcome following manipulation under anesthesia for stiffness with one group receiving IV dexamethasone and oral celecoxib at the time of manipulation to a control group receiving manipulation alone. Measured outcomes will include pain, range of motion, as well as subjective outcome scores.
Participating Mayo Clinic locations
Study statuses change often. Please contact us for help.
Print study details
Site IRB:
- Rochester, Minnesota: 15-009075
NCT ID:
NCT02739035Sponsor Protocol Number:
15-009075
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Rochester, Minn.
MIMO Clinical Trial
Study type:
Interventional What is this?
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
Study phase:
IV What is this?
During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.
About this study
Objectives
- Primary objective: Determine if there is a clinically significant difference in percent Cobb curve correction in a low- vs. high-implant density cohort through a prospective randomized controlled trial.
Design and Outcomes
- Randomized clinical trial of equivalence to test the efficacy and safety of low vs. high implant density instrumentation for spine deformity surgery in AIS patients with Lenke IA curve patterns.
Interventions and Duration
- Intervention: low-implant density group or high-implant density group.
- Duration: 2 years.
Sample Size and Population
- Target population: 10 to 17 years old with AIS who will undergo instrumented spinal fusion.
- Sample size needed (power = 90%) is 174 subjects with 87 in each group.
Participating Mayo Clinic locations
Study statuses change often. Please contact us for help.
Print study details
Site IRB:
- Rochester, Minnesota: 12-009523
NCT ID:
NCT01792609Sponsor Protocol Number:
MIMO1208M18202
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Rochester, Minn.
Riluzole in Spinal Cord Injury Study
Study type:
Interventional What is this?
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
Study phase:
II/III What is this?
During the early phases (phases 1 and 2), researchers assess safety, side effects, optimal dosages and risks/benefits. In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. They also compare the safety of the new treatment with that of current treatments. Phase 3 trials include large numbers of people to make sure that the result is valid. There are also less common very early (phase 0) and later (phase 4) phases. Phase 0 trials are small trials that help researchers decide if a new agent should be tested in a phase 1 trial. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.
About this study
The aim of this study is to evaluate efficacy and safety of riluzole in the treatment of patients with acute SCI. The primary objective is to evaluate the superiority of riluzole, at a dose of 2 x 100 mg the first 24 hours followed by 2 x 50 mg for the following 13 days after injury, as compared to placebo, in change between 180 days and baseline in motor outcomes as measured by International Standards for Neurological Classification of Spinal Cord Injury Examination (ISNCSCI) Motor Score, in patients with acute traumatic SCI, presenting to the hospital less than 12 hours after injury. Secondary objectives are to evaluate the effects of riluzole on overall neurologic recovery, sensory recovery, functional outcomes, quality of life outcomes, health utilities, mortality, and adverse events. The working hypothesis is that the riluzole treated subjects will experience superior motor, sensory, functional, and quality of life outcomes as compared to those receiving placebo, with an acceptable safety profile.
Participating Mayo Clinic locations
Study statuses change often. Please contact us for help.
Print study details
Site IRB:
- Rochester, Minnesota: 13-003367
NCT ID:
NCT01597518Sponsor Protocol Number:
SPN-12-001
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Rochester, Minn.
Study of Suture Repair of Torn Meniscus in the Knee
Study type:
Interventional What is this?
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
About this study
Horizontal meniscus tears meeting specified criteria will be repaired by any commonly used suture technique. Subjects will be followed for 2 years to evaluate the effectiveness of the repair, by assessing the re-operation rate, and by assessing improvements in knee pain and knee function.
Participating Mayo Clinic locations
Study statuses change often. Please contact us for help.
Print study details
Site IRB:
- Rochester, Minnesota: 14-006973
NCT ID:
NCT02237001Sponsor Protocol Number:
CTX-CP001
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Rochester, Minn.
A Study of Screening High School, Collegiate, and Olympic/Professional-level Athletes for Characteristics that May Lead to Injury
Study type:
Observational What is this?
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
About this study
The purpose of this study is to perform comprehensive clinical and biomechanical screening of high school, collegiate-level, and Olympic/professional-level athletes to identify individual functional and performance deficits that can lead to non-contact lower extremity injury.
Participating Mayo Clinic locations
Study statuses change often. Please contact us for help.
Print study details
Site IRB:
- Rochester, Minnesota: 15-004531
Sponsor Protocol Number:
15-004531
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Rochester, Minn.
Comparative Effectiveness Between Microprocessor Knees and Non-Microprocessor Knees
Study type:
Interventional What is this?
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
About this study
This study will assess if the functional performance and musculoskeletal outcome of transfemoral amputees are improved after receiving a Microprocessor Knee (MPK) compared to a Non-Microprocessor Knees (NMPK).
Participating Mayo Clinic locations
Study statuses change often. Please contact us for help.
Print study details
Site IRB:
- Rochester, Minnesota: 14-002930
NCT ID:
NCT02240186Sponsor Protocol Number:
14-002930
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Scottsdale/Phoenix, Ariz.
A Study Comparing Ultrasound versus Nerve Stimulator Guidance Used with a Nerve Block for Postoperative Knee Pain Control
Study type:
Observational What is this?
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
About this study
The purpose of this study is to compare the use of ultrasound guidance and nerve stimulator guidance with a popliteal (knee) nerve block for postoperative pain control.
Participating Mayo Clinic locations
Study statuses change often. Please contact us for help.
Print study details
Site IRB:
- Scottsdale/Phoenix, Arizona: 14-008987
Sponsor Protocol Number:
14-008987
March 24, 2015